Abstract
In response to inhibition of purine de novo biosynthesis by methotrexate (MTX), an increase in the availability of 5-phosphoribosyl-1-pyrophosphate (PRPP) occurs. As a result of this increased availability of PRPP, potentiation of 6-mercaptopurine (6MP) incorporation can be expected in cells with an active purine de novo synthesis (Fig.1).
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© 1986 Plenum Press, New York
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Bökkerink, J.P.M. et al. (1986). Increased Availability of Phosphoribosyl Pyrophosphate as the Basis for Enhanced 6-Mercaptopurine Incorporation by Methotrexate, in Cultured Human Lymphoblasts. In: Nyhan, W.L., Thompson, L.F., Watts, R.W.E. (eds) Purine and Pyrimidine Metabolism in Man V. Advances in Experimental Medicine and Biology, vol 195B. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-1248-2_21
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DOI: https://doi.org/10.1007/978-1-4684-1248-2_21
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