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Toxicity and Antitumor Effect of 5-Fluorouracil and its Rescue by Uridine

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Purine and Pyrimidine Metabolism in Man V

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 195B))

Abstract

The pyrimidine analog 5-fluorouracil (5FU) has been used in the treatment against several solid carcinomas, mainly of the colon, for several decades (1). However, overall response rate is only about 20%, while gastrointestinal and myeloid toxicity are dose-limiting (1). Research on 5FU has been directed towards enhancing 5FU anabolism by combination with e.g. methotrexate (2) or thymidine (3) and towards the development of several analogs of 5FU. One recent analog, Doxifluridine (5′-deoxy-5-fluorouridine, 5’dFUR) showed an improved therapeutic index against a broad range of murine and rat tumors (4,5) and therapeutic activity in human advanced rectosigmoid adenocarcinoma (6).

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Author information

Authors and Affiliations

  1. Department of Oncology, Free University Hospital, P.O. Box 7075, 1007, MB, Amsterdam, The Netherlands

    G. J. Peters, J. van Dijk, C. van Groeningen, E. J. Laurensse, A. Leyva, J. Lankelma & H. M. Pinedo

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  1. G. J. Peters
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  2. J. van Dijk
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  3. C. van Groeningen
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  4. E. J. Laurensse
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  5. A. Leyva
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  6. J. Lankelma
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  7. H. M. Pinedo
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Editor information

Editors and Affiliations

  1. University of California, San Diego La Jolla, California, USA

    W. L. Nyhan

  2. Scripps Clinic and Research Foundation, La Jolla, California, USA

    L. F. Thompson

  3. M. R. C. Clinical Research Center, Harrow, UK

    R. W. E. Watts

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© 1986 Plenum Press, New York

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Peters, G.J. et al. (1986). Toxicity and Antitumor Effect of 5-Fluorouracil and its Rescue by Uridine. In: Nyhan, W.L., Thompson, L.F., Watts, R.W.E. (eds) Purine and Pyrimidine Metabolism in Man V. Advances in Experimental Medicine and Biology, vol 195B. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-1248-2_19

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  • DOI: https://doi.org/10.1007/978-1-4684-1248-2_19

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-1250-5

  • Online ISBN: 978-1-4684-1248-2

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