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Purine and Pyrimidine Metabolism in Man V pp 75–77Cite as

Regulatory Aspects of Hypoxanthine Uptake by Human Erythrocytes

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 195B))

Abstract

Mature human erythrocytes are incapable of de novo synthesis of purine rings, thus the turnover results from continual entry and release of purines into the plasma. The synthesis of IMP from exogenous hypoxanthine is thought to be primarily governed by the catalytic capacity of P-Rib-PP synthetase and the intracellular avaibility of P-Rib-PP (1-3).

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References

  1. A.W. Murray, The biological significance of purine salvage, Ann. Rev. Biochem. 40: 773 (1971).

    Article  Google Scholar 

  2. J.B. Wyngaarden and W.N. Kelley, “Gout and Hyperuricemia”, Grune and Stratton, New York (1976).

    Google Scholar 

  3. A. Hershko, A. Razin, and J. Mager, Regulation of the synthesis of 5-phosphoribosyl-1-pyrophosphate in intact red blood cells and in cell-free; preparations, Biochim. Biophys. Acta 184: 64 (1969).

    Article  CAS  Google Scholar 

  4. I.H. Fox and W.N. Kelley, Human phosphoribosylpyrophosphate synthetase: distribution, purification and properties, J. Biol. Chem. 247: 5739 (1972).

    Google Scholar 

  5. A. Giacomello and C. Salerno, Hypoxanthine uptake by human erythrocytes, FEBS lett. 107: 203 (1979).

    Article  CAS  Google Scholar 

  6. J.B. Wyngaarden and W.N. Kelley, Gout, in: “The Metabolic Basis of Inherited Disease”, J.B. Stanbury, J.B. Wyngaarden, D.S. Fredrickson, J.L. Goldstein, and M.S. Brown, eds., McGraw-Hill Book, New York (1983).

    Google Scholar 

  7. N. Sciaky, A. Razin, B. Gazit, and J. Mager, Regulatory aspects of the; synthesis of 5-phosphoribosyl-l-pyrophosphate in human red blood cells, Adv. Exp. Med. Biol. 41A: 87 (1974).

    Article  CAS  Google Scholar 

  8. K. Imai, “Allosteric Effects in Haemoglobin”, University Press, Cambridge (1982).

    Google Scholar 

  9. C. Salerno and A. Giacomello, Hypoxanthine-guanine exchange by intact human erythrocytes, Biochemistry 24: 1306 (1985).

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Institutes of Rheumatology and Biological Chemistry, University of Rome, and C.N.R. Centre for Molecular Biology, Rome, Italy

    C. Salerno, G. Gerber & A. Giacomello

  2. Institute of Physiological and Biological Chemistry, Humboldt University, Berlin, DDR, USA

    C. Salerno, G. Gerber & A. Giacomello

Authors
  1. C. Salerno
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  2. G. Gerber
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  3. A. Giacomello
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Editor information

Editors and Affiliations

  1. University of California, San Diego La Jolla, California, USA

    W. L. Nyhan

  2. Scripps Clinic and Research Foundation, La Jolla, California, USA

    L. F. Thompson

  3. M. R. C. Clinical Research Center, Harrow, UK

    R. W. E. Watts

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© 1986 Plenum Press, New York

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Salerno, C., Gerber, G., Giacomello, A. (1986). Regulatory Aspects of Hypoxanthine Uptake by Human Erythrocytes. In: Nyhan, W.L., Thompson, L.F., Watts, R.W.E. (eds) Purine and Pyrimidine Metabolism in Man V. Advances in Experimental Medicine and Biology, vol 195B. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-1248-2_12

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  • DOI: https://doi.org/10.1007/978-1-4684-1248-2_12

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-1250-5

  • Online ISBN: 978-1-4684-1248-2

  • eBook Packages: Springer Book Archive

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