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Mechanisms of Tumor Invasion and Their Potential Therapeutic Modifications

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Biological Responses in Cancer

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Abstract

Invasion and metastases are the major causes of morbidity and mortality for patients with malignant solid tumors. Many patients already have metastases at the time of primary tumor diagnosis. Individual patients’ tumors vary widely in aggressiveness. One patient’s tumor may grow to a larger size and fail to metastasize. Another patient’s tumor of similar histologic appearance may metastasize at a very early stage. Consequently, there is a great clinical need to develop new methods to (1) prevent local tumor invasion, (2) identify and treat clinically occult micrometastases, and (3) predict the aggressiveness of a patient’s individual tumor. The purpose of this chapter is to summarize basic science developments in oncology that provide strategies for developing such methods.

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References

  • Abelev, G. I., 1974, a-Fetoprotein as a marker of embryo-specific differentiations in normal and tumor tissue, Transplant. Rev. 20: 3–37.

    Google Scholar 

  • Abelev, G. I., Perova, S. D., Khramkova, N. I., Postnikova, Z. A., and Irlin, I. S., 1963, Production of embryonal a-globulin by transplantable mouse hepatomas, Transplantation 1: 174–186.

    Article  PubMed  CAS  Google Scholar 

  • Alexander, W. F., Mills, B. K., and Lichtenstein, J. R., 1979, Isolation of collagen A and B chains from purified basement membranes, Fed. Proc. 38: 1407.

    Google Scholar 

  • Alpert, E., Coston, R. C., and Drysdale, J. W., 1973, Carcinofetal human isoferritins, Nature 242: 194–196.

    Article  PubMed  CAS  Google Scholar 

  • Anderson, L. C., Gahmberg, C. G., Nilsson, K., and Wigzell, H., 1977, Surface glycoprotein patterns of normal and malignant human lymphoid cells. I. T cells, T blasts and leukemic T cell lines, Int. J. Cancer 20: 702–707.

    Article  Google Scholar 

  • Astrup, T., and Permin, P. M., 1947, Fibrinolysis in the animal organism, Nature 159: 681–682.

    Article  PubMed  CAS  Google Scholar 

  • Avis, P., Biol, M. I., and Lewis, M. G., 1973, Tumor associated fetal antigens in human tumors, J. Natl. Cancer Inst. 51: 1063–1066.

    PubMed  CAS  Google Scholar 

  • Bailey, A. J., Shellswell, G. B., and Duance, V. C., 1979, Identification and change of collagen types in differentiating myoblasts and developing chick muscle, Nature 278: 67–69.

    Article  PubMed  CAS  Google Scholar 

  • Banwo, O., Versey, J., and Hobbs, J. R., 1974, New oncofetal antigen from human pancreas, Lancet 1: 643–645.

    Article  PubMed  CAS  Google Scholar 

  • Barsky, S. H., Togo, S., Garbisa, S., and Liotta, L. A., 1983a, Type IV collagenase immunoreactivity in invasive breast carcinoma, Lancet 1: 296–297.

    Article  PubMed  CAS  Google Scholar 

  • Barsky, S. H., Siegel, G. P., Jannotta, F., and Liotta, L. A., 1983b, Loss of basement membrane components by invasive tumors but not by their benign counterparts, Lab. Invest. 49: 140–147.

    PubMed  CAS  Google Scholar 

  • Barsky, S. H., Rao, C. N., Hyams, D., and Liotta, L. A., 1984a, Characterization of a laminin receptor from human breast carcinoma tissue, Breast Cancer Res. Treat. 4: 181–188.

    CAS  Google Scholar 

  • Barsky, S. H., Rao, C. N., Williams, J. E., and Liotta, L. A., 19846, Laminin molecular domains which alter metastasis in a murine model, J. Clin. Invest. 74: 843–848.

    Google Scholar 

  • Bauer, E. A., Gordon, J. M., Reddick, M. E., and Eisen, A. Z., 1977, Quantitation and immunocytochemical localization of human skin collagenase in basal cell carcinoma, J. Invest. Dermatol. 69: 363–367.

    Article  PubMed  CAS  Google Scholar 

  • Bauer, E. A., Uitto, J., Walders, R. C., and Eisen, A. Z., 1979, Enhanced collagenase production by fibroblasts derived from human basal cell carcinomas, Cancer Res. 39: 4594–4599.

    PubMed  CAS  Google Scholar 

  • Baylin, S. B., 1982, Clonal selection and heterogeneity of human solid neoplasms, in: Design of Models for Testing Cancer Therapeutic Agents ( I. J. Fidler and R. J. White, eds.), Van Nostrand, New York, pp. 50–64.

    Google Scholar 

  • Beers, W. H., Strickland, S., and Reich, E., 1975, Ovarian plasminogen activator: Relationship to ovulation and hormonal regulation, Cell 6: 387–394.

    Article  PubMed  CAS  Google Scholar 

  • Bernstein, I. D., Tam, M. R., and Nowinski, R. C., 1980, Mouse leukemia: Therapy with monoclonal antibodies against a thymus differentiation antigen, Science 207: 68–71.

    Article  PubMed  CAS  Google Scholar 

  • Biswas, C., Moran, W. P., Bloch, K. J., and Gross, J., 1978, Collagenolytic activity of rabbit V2-carcinoma growing at multiple sites, Biochem. Biophys. Res. Commun. 80: 33–38.

    CAS  Google Scholar 

  • Björklund, B., 1976, Tissue polypeptide antigen (TPA) in cancer and other conditions, in: Oncodevelopmental Gene Expression ( W. H. Fishman and S. Sell, eds.), Academic Press, New York, pp. 501–508.

    Google Scholar 

  • Blumberg, P. M., and Robbins, P. W., 1975, Effect of proteases on activation of resting chick embryo fibroblasts and cell surface proteins, Cell 6: 137–147.

    Article  PubMed  CAS  Google Scholar 

  • Boon, T., and Kellerman, O., 1977, Rejection by syngeneic mice of cell variants obtained by mutagenesis of a malignant teratocarcinoma cell line, Proc. Natl. Acad. Sci. USA 74: 272–275.

    Article  PubMed  CAS  Google Scholar 

  • Bornstein, P., and Sage, H., 1980, Structurally distinct collagen types, Annu. Rev. Biochem. 49: 957–1003.

    Article  PubMed  CAS  Google Scholar 

  • Brown, R. A., Shuttleworth, C. A., and Weiss, J. B., 1978, Three new alpha-chains of collagen from a non-basement membrane source, Biochem. Biophys. Res. Commun. 80: 866–872.

    Article  PubMed  CAS  Google Scholar 

  • Buchanan, J. M., Bo Chen, L., and Zetter, B. R., 1976, Protease-related effects in normal and transformed cells, in: Cancer Enzymology ( J. Schultz and F. Ahmad, eds.), Academic Press, New York, pp. 1–22.

    Google Scholar 

  • Bumol, T. F., and Reisfeld, R. A., 1982, Unique glycoprotein—proteoglycan complex defined by monoclonal antibody on human melanoma cells, Proc. Natl. Acad. Sci. USA 79: 1245–1249.

    Article  PubMed  CAS  Google Scholar 

  • Bumol, T. F., Wang, Q. C., Reisfeld, R. A., and Kaplan, N. O., 1983, Monoclonal antibody and an antibody—toxin conjugate to a cell surface proteoglycan of melanoma cells suppress in vivo tumor growth, Proc. Natl. Acad. Sci. USA 80: 529–533.

    Article  PubMed  CAS  Google Scholar 

  • Burger, M. M., 1970, Proteolytic enzymes initiating cell division and escape from contact inhibition of growth, Nature 227: 170–171.

    Article  PubMed  CAS  Google Scholar 

  • Burgeson, R. E., El Adli, F. A., Kaitila, I. I., and Hollister, D. W., 1976, Fetal membrane collagens: Identification of two new collagen alpha chains, Proc. Natl. Acad. Sci. USA 73: 2579–2583.

    Article  PubMed  CAS  Google Scholar 

  • Butler, T. P., and Gullino, P. M., 1975, Quantitation of cell shedding into efferent blood of mammary adenocarcinoma, Cancer Res. 35: 512–516.

    PubMed  CAS  Google Scholar 

  • Calabresi, P., Dexter, D. L., and Heppner, G. H., 1979, Clinical and pharmacological implications of cancer cell differentiation and heterogeneity, Biochem. Pharmacol. 28: 1933–1941.

    Article  PubMed  CAS  Google Scholar 

  • Ceriani, R. L., Thompson, K. E., Peterson, J. A., and Abraham, S., 1977, Surface differentiation antigens of human mammary epithelial cells carried on the human milk fat globule, Proc. Natl. Acad. Sci. USA 74: 582–586.

    Article  PubMed  CAS  Google Scholar 

  • Ceriani, R. L., Sasaki, M., Sussman, H., Wara, W. M., and Blank, E. W., 1982, Circulating human mammary epithelial antigens in breast cancer, Proc. Natl. Acad. Sci. USA 79: 5420–5424.

    Article  PubMed  CAS  Google Scholar 

  • Christman, J. K., Silverstein, S., and Acs, G., 1977, Plasminogen activation, in: Proteinases in Mammalian Cells and Tissues, Volume 2 ( A. J. Barrett, ed.), Elsevier/North-Holland Biomedical Press, Amsterdam, pp. 91–149.

    Google Scholar 

  • Chung, A. E., Rhodes, R. K., and Miller, E. J., 1976, Isolation of three collagenous components of probable basement membrane origin from several tissues, Biochem. Biophys. Res. Cornmun. 71: 1167–1174.

    Article  CAS  Google Scholar 

  • Chung, A. E., Jaffe, R., Freeman, I. L., Vergnes, J. P., Braginski, J. E., and Carlin, B., 1979, Properties of a basement membrane-related glycoprotein synthesized in culture by a mouse embryonal carcinoma-derived cell line, Cell 16: 277–287.

    Article  PubMed  CAS  Google Scholar 

  • Dabbous, M. K., Roberts, A. N., and Brinkley, S. B., 1977, Collagenase and neutral protease activities in cultures of rabbit VX-2 carcinoma, Cancer Res. 37: 3537–3544.

    PubMed  CAS  Google Scholar 

  • Dabbous, M. K., Hammouda, O., and Brinkley, S. B., 1981, Isolation and partial characterization of bovine gingival AB collagen, Mol. Cell. Biochem. 34: 87–93.

    Article  PubMed  CAS  Google Scholar 

  • Dabbous, M. K., El-Torky, M., Haney, L., Sobhy, N., and Brinkley, S. B., 1983, Separation of VX-2 rabbit carcinoma-derived cells capable of releasing collagenase, Exp. Mol. Pathol. 38: 1–21.

    Article  PubMed  CAS  Google Scholar 

  • Dresden, M. H., Heilman, S. A., and Schmidt, J. D., 1972, Collagenolytic enzymes in human neoplasms, Cancer Res. 32: 993–996.

    PubMed  CAS  Google Scholar 

  • Drewa, G., Zbytniewski, Z., and Kanclerz, A., 1978, Activity of some lysosomal hydrolases in the homogenates of transplantable melanotic and amelanotic melanoma in golden hamster (Mesocricetus auratus, Waterhouse), Arch. Geschwulstforsch. 48: 198–201.

    PubMed  CAS  Google Scholar 

  • Easty, G. C., and Easty, D. M., 1976, Mechanism of tumor invasion, in: Scientific Foundations of Oncology ( T. Symington and R. L. Carter, eds.), Heinemann, London, pp. 167–172.

    Google Scholar 

  • Eccles, S. A., 1982, Host immune mechanisms important in the control of tumor metastasis, in: Tumor Immunity in Prognosis: The Role of Mononuclear Cell Infiltration ( J. S. Haskill, ed.), Marcel Dekker, New York, pp. 39–74.

    Google Scholar 

  • Eeckhout, Y., and Vaes, G., 1977, Further studies on the activation of procollagenase, the latent precursor of bone collagenase: Effects of lysosomal cathepsin B, plasmin and kallikrein, and spontaneous activation, Biochem. J. 166: 21–31.

    PubMed  CAS  Google Scholar 

  • Ekblom, P., 1981, Formation of basement membranes in the embryonic kidney: An immunohistological study, J. Cell Biol. 91: 1–10.

    Article  PubMed  CAS  Google Scholar 

  • Engel, J., Odermatt, E., Engel, A., Madri, J. A., Furthmayr, H., Rohde, H., and Timpl, R., 1981, Shapes, domain organizations and flexibility of laminin and fibronectin, two multifunctional proteins of the extracellular matrix, J. Mol. Biol. 150: 97–120.

    Article  PubMed  CAS  Google Scholar 

  • Fernandez-Cruz, E., Gilman, S. C., and Feldman, J. D., 1982, Immunotherapy of a chemically-induced sarcoma in rats: Characterization of the effector T cell subset and nature of suppression, J. Immunol. 128: 1112–1117.

    PubMed  CAS  Google Scholar 

  • Fessier, L. I., Robinson, W. J., and Fessier, J. H., 1981, Biosynthesis of procollagen [(pro alpha 1 V) 2 (pro alpha 2 V)] by chick tendon fibroblasts and procollagen (pro alpha 1 V) 3 by hamster lung cell cultures, J. Biol. Chem. 256: 9646–9651.

    Google Scholar 

  • Fessier, L. I., Duncan, K. G., Fessler, J. H., Salo, T., and Tryggvason, K., 1974, Characterization of the procollagen IV cleavage products produced by a specific tumor collagenase, J. Biol. Chem. 259: 9783–9789.

    Google Scholar 

  • Fialkow, P. J., 1976, Clonal origin of human tumors, Biochim. Biophys. Acta. 458: 283–321.

    CAS  Google Scholar 

  • Fidler, I. J., 1970, Metastasis: Quantitative analysis of distribution and fate of tumor emboli labeled with 125I-5 iodo-2’deoxyuridine, J. Natl. Cancer Inst. 45: 733–782.

    Google Scholar 

  • Fidler, I. J., and Kripke, M. J., 1977, Metastasis results from preexisting variant cells within a malignant tumor, Science 197: 893–895.

    Article  PubMed  CAS  Google Scholar 

  • Fidler, I. J., and Nicolson, G. L., 1981, Immunology of experimental metastatic melanoma, Cancer Biol. Rev. 2: 171–234.

    Google Scholar 

  • Fidler, I. J., and Poste, G., 1982, Macrophage mediated destruction of malignant tumor cells and new strategies for the therapy of metastatic disease, Immunopathology 5: 161–174.

    CAS  Google Scholar 

  • Fidler, I. J., and Raz, A., 1981, The induction of tumoricidal rat macrophages by lymphokines, in: Lymphokines, Volume 3 ( E. Pick, ed.), Academic Press, New York, pp. 345–363.

    Google Scholar 

  • Fischer, A., 1925, Beitrag zur Biologie der Gewebszellen. Eine vergleichen-biologishe Gewebszellen in vitro, Arch. Entwicklungsmech. Org. 104: 210–261.

    Google Scholar 

  • Fisher, M. S., and Cifone, M. A., 1981, Enhanced metastatic potential of murine fibrosarcomas treated in vitro with ultraviolet radiation, Cancer Res. 41: 3018–3023.

    PubMed  CAS  Google Scholar 

  • Foidart, J. M., Bere, E. W., Yaar, M., Rennard, S. I., Gullino, M., Martin, G. R., and Katz, S. I., 1980, Distribution and immunoelectron microscopic localization of laminin, a noncollagenous basement membrane glycoprotein, Lab. Invest. 42: 336–342.

    PubMed  CAS  Google Scholar 

  • Foulds, L., 1956, The histologic analysis of mammary tumors in mice. I. Scope of investigations and general principles of analysis, J. Natl. Cancer Inst. 17: 701–754.

    PubMed  CAS  Google Scholar 

  • Fritze, D., and Mach, J. P., 1975, Identification of new oncofoetal antigen associated with several types of human carcinomas, Nature 258: 734–737.

    Article  Google Scholar 

  • Gabbiani, G., 1979, The cytoskeleton in cancer cells in animals and humans, Meth. Achiev. Exp. Pathol. 9: 231–249.

    CAS  Google Scholar 

  • Gahmberg, C. G., Jokinen, M., and Sandersson, L. C., 1979, Expression of the major red cell sialoglycoprotein, glycophorin A, in the human leukemic cell line K562, J. Biol. Chem. 254: 7442–7448.

    PubMed  CAS  Google Scholar 

  • Garbisa, S., Liotta, L. A., Tryggvason, K., and Siegel, G. P., 1981, Antibodies to collagenase resistant terminal regions of pro-type IV collagen recognize whole basement membrane and 7-S collagen, FEBS Lett. 127: 257–262.

    Article  PubMed  CAS  Google Scholar 

  • Gershman, H., Katzin, W., and Cook, R. T., 1978, Motility of cells from solid tumors, Int. J. Cancer 21: 309–316.

    Article  PubMed  CAS  Google Scholar 

  • Gidlund, M., Orn, A., Pattengale, P. K., Jansson, M., Wigzell, H., and Nilsson, K., 1981, Natural killer cells kill tumor cells at a given stage of differentiation, Nature 292: 848–850.

    Article  PubMed  CAS  Google Scholar 

  • Giraldi, T., Sava, G., Perissin, L., and Zorzet, S., 1984, Primary tumor growth and formation of spontaneous lung metastases in mice bearing Lewis carcinoma treated with proteinase inhibitors, Anticancer Res. 4: 221–224.

    PubMed  CAS  Google Scholar 

  • Gold, P., and Freedman, S. O., 1965, Demonstration of tumor specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques, J. Exp. Med. 121: 439–462.

    Article  PubMed  CAS  Google Scholar 

  • Goldberg, A. R., 1974, Increased protease levels in transformed cells: A casein overlay assay for the detection of plasminogen activator production, Cell 2: 95–102.

    Article  PubMed  CAS  Google Scholar 

  • Grimes, W. J., 1970, Sialic acid transferases and sialic acid levels in normal and transformed cells, Biochemistry 9: 5083–5092.

    Article  PubMed  CAS  Google Scholar 

  • Gross, J., 1976, Aspects of animal collagenases, in: Biochemistry of Collagen ( G. N. Ramachandran and A. H. Reddi, eds.), Plenum Press, New York, pp. 275–317.

    Google Scholar 

  • Gross, J., and Lapière, C. M., 1962, Collagenolytic activity in amphibian tissues: A tissue culture assay, Proc. Natl. Acad. Sci. USA 48: 1014–1022.

    Article  PubMed  CAS  Google Scholar 

  • Gross, J., Highberger, J. H., Johnsen-Wint, B., and Biswas, C., 1980, Role of action and regulation of tissue collagenases, in: Collagenase in Normal and Pathological Connective Tissues ( D. E. Woolley and J. M. Evanson, eds.), John Wiley & Sons, New York, pp. 11–35.

    Google Scholar 

  • Grossman, Z., and Herberman, R. B., 1982, Hypothesis on the development of natural killer cells and their relationship to T cells, in: NK Cells and Other Natural Effector Cells ( R. B. Herberman, ed.), Academic Press, New York, pp. 229–238.

    Chapter  Google Scholar 

  • Häkkinen, I. P. T., 1974, FSA-foetal sulpho-glycoprotein antigen associated with gastric cancer, Transplant Rev. 20: 61–76.

    PubMed  Google Scholar 

  • Hakomori, S., and Kannagi, R., 1983, Glycosphingolipids as tumor-associated and differentiation markers, J. Natl. Cancer Inst. 71: 231–251.

    PubMed  CAS  Google Scholar 

  • Hanna, N., and Burton, R., 1981, Definitive evidence that natural killer (NK) cells inhibit experimental tumor metastasis in vivo, J. Immunol. 127: 1754–1758.

    PubMed  CAS  Google Scholar 

  • Hart, I. R., Talmadge, J. E., and Fidler, I. J., 1981, Metastatic behaviour of a murine reticulum cell sarcoma exhibiting organ specific growth, Cancer Res. 41: 1281–1287.

    PubMed  CAS  Google Scholar 

  • Hassell, J. R., Gehron-Robey, P., Barrach, H. J., Wilczek, J., Rennard, S. I., and Martin, G. R., 1980, Isolation of a heparan sulfate-containing proteoglycan from basement membrane, Proc. Natl. Acad. Sci. USA 77: 4494–4498.

    Article  PubMed  CAS  Google Scholar 

  • Hayashi, H., Yoshida, K., Ozaki, T., and Ushijima, K., 1970, Chemotactic factor associated with invasion of cancer cells, Nature 226: 174–175.

    Article  PubMed  CAS  Google Scholar 

  • Hayashi, T., Nakamura, T., Hori, H., and Nagai, J., 1980, Degradation rates of type II and III collagens by tadpole collagenase are modulated by mutual presence, J. Biochem. (Tokyo) 87: 993–995.

    CAS  Google Scholar 

  • Heathcote, J. G., Bailey, A. J., and Grant, M. E., 1980, Studies on the assembly of the rat lens capsule: Biosynthesis of a cross-linked collagenous component of high molecular weight, Biochem. J. 190: 229–237.

    PubMed  CAS  Google Scholar 

  • Hibbs, J. B., Jr., 1974, Discrimination between neoplastic and non-neoplastic cells in vitro by activated macrophages, J. Natl. Cancer Inst. 53: 1487–1492.

    PubMed  Google Scholar 

  • Hogan, B. L. M., 1980, High molecular weight extracellular proteins synthesized by endoderm cells derived from mouse teratocarcinoma cells and normal extraembryonic membranes, Dev. Biol. 76: 275–285.

    Article  PubMed  CAS  Google Scholar 

  • Hogan, B. L. M., Cooper, A. R., and Kurkinen, M., 1980, Incorporation into Reichert’s membrane of laminin-like extracellular proteins synthesized by parietal endoderm cells of the mouse embryo, Dev. Biol. 80: 289–300.

    Article  PubMed  CAS  Google Scholar 

  • Howe, C. C., and Bolter, D., 1980, Identification of noncollagenous basement membrane glycopolypeptides synthesized by mouse parietal endoderm and an entodermal cell line, Dev. Biol. 77: 480–487.

    Article  PubMed  CAS  Google Scholar 

  • Huang, C. C., Abramson, M., Schilling, R. W., and Salorne, R. G., 1976, Collagenase activity in tumors of the head and neck, Trans. Am. Acad. Ophthalmol. Otolaryngol. 82: 138–141.

    Google Scholar 

  • Hynes, R. O., 1973, Alteration of cell-surface proteins by viral transformation and by proteolysis, Proc. Natl. Acad. Sci. USA 70: 3170–3174.

    Article  PubMed  CAS  Google Scholar 

  • Iannaccone, P. M.. Gardner, R. L., and Harris. H., 1978. The cellular origin of chemically induced tumors, J. Cell Sci. 29: 249–269.

    CAS  Google Scholar 

  • Jimenez, S. A., Yankowski, R., and Bashey, R. I., 1978, Identification of two new collagen alpha-chains in extracts of lathyritic chick embryo tendons, Biochem. Biophys. Res. Commun. 81: 1298–1306.

    Article  PubMed  CAS  Google Scholar 

  • Kalebic, T., Garbisa, S., Glaser, B., and Liotta, L. A., 1983, Basement membrane collagen: Degradation by migrating endothelial cells, Science 221: 281–283.

    Article  PubMed  CAS  Google Scholar 

  • Kanwar, Y. S., and Farquhar, M. G., 1979, Anionic sites in the glomerular basement membrane: In vivo and in vitro localization of the laminae rarae cationic probes, J. Cell Biol. 81: 137–153.

    Article  PubMed  CAS  Google Scholar 

  • Kefalides, N. A., Alper, R., and Clark, C. C., 1979, Biochemistry and metabolism of basement membranes, Int. Rev. Cytol. 61: 167–228.

    Article  PubMed  CAS  Google Scholar 

  • Kennedy, A. R., and Little, J. B., 1978, Protease inhibitors suppress radiation-induced malignant transformation in vitro, Nature 276: 825–826.

    Article  PubMed  CAS  Google Scholar 

  • Kerbel, R. S., Dennis, J. W., Largarde, A. E., and Frost, P., 1982, Tumor progression in metastatis: An experimental approach using lectin resistant tumor variants, Cancer Met. Rev. 1: 99–140.

    Article  CAS  Google Scholar 

  • Kim, U., 1970, Metastasizing mammary carcinoma in rats: Induction and study of their immunogenicity, Science 67: 72–74.

    Article  Google Scholar 

  • Kim, U., Baumler, A., Carruthers, C., and Bielat, K., 1975, Immunological escape mechanism in spontaneously metastasizing mammary tumors, Proc. Natl. Acad. Sci. USA 72: 1012–1016.

    Article  PubMed  CAS  Google Scholar 

  • Kleinman, H. K., Klebe, R. J., and Martin, G. R., 1981, Role of collagenous matrices in the adhesion and growth of cells, J. Cell Biol. 88: 473–485.

    Article  PubMed  CAS  Google Scholar 

  • Kleinman, H. K., McGarvey, M. L., Liotta, L. A., Gehron-Robey, P., Tryggvason, K., and Martin, G. R., 1982, Isolation and characterization of type IV procollagen, laminin and heparan sulfate proteoglycan from the EHS sarcoma, Biochemistry 21: 6188–6193.

    Article  PubMed  CAS  Google Scholar 

  • Koono, M., Ushijima, K., and Hayashi, H., 1974, Studies on the mechanisms of invasion in cancer. III. Purification of a neutral protease of rat ascites hepatoma cells associated with production of chemotactic factor for cancer cells, Int. J. Cancer 13: 105–115.

    Article  PubMed  CAS  Google Scholar 

  • Koprowski, H., Steplewski, Z., Herlyn, D., and Herlyn, M., 1978, Study of antibodies against human melanoma produced by somatic cell hybrids, Proc. Natl. Acad. Sci. USA 75: 3405–3409.

    Article  PubMed  CAS  Google Scholar 

  • Koprowski, H., Herlyn, M., and Steplewski, Z., 1981, Specific antigen in serum of patients with colon carcinoma, Science 212: 53–55.

    Article  PubMed  CAS  Google Scholar 

  • Krueger, J. G., Garber, E. A., Goldberg, A. R., and Hanafusa, H., 1982, Changes in amino-terminal sequences of pp60’ lead to decreased membrane association and decreased in vivo tumorigenicity, Cell 28: 889–896.

    Article  PubMed  CAS  Google Scholar 

  • Krupey, J., Gold, P., and Freedman, S. O., 1968, Physicochemical studies of the carcinoembryonic antigens of the human digestive system, J. Exp. Med. 128: 387–398.

    Article  PubMed  CAS  Google Scholar 

  • Kuettner, K. E., Soble, L., Croxen, R. L., Marczynska, B., Hiti, J., and Harper, E., 1977, Tumor cell collagenase and its inhibition by a cartilage-derived protease inhibitor, Science 196: 653–654.

    Article  PubMed  CAS  Google Scholar 

  • Laug, W. E., Tokes, Z. A., Benedict, W. F., and Sorgente, N., 1980, Anchorage independent growth and plasminogen activator production by bovine endothelial cells, J. Cell Biol. 84: 281–293.

    Article  PubMed  CAS  Google Scholar 

  • Laurie, G. W., Leblond, C. P., and Martin, G. R., 1982, Localization of type IV collagen, laminin, heparan sulfate proteoglycan, and fibronectin to the basal lamina of basement membranes, J. Cell Biol. 95: 340–344.

    Article  PubMed  CAS  Google Scholar 

  • Leavitt, J., Bushar, G., Kakunaga, T., Hamada, H., Hirakawa, T., Goldman, D., and Merril, C., 1982, Variations in expression of mutant beta actin accompanying incremental increases in human fibroblast tumorigenicity, Cell 28: 259–268.

    Article  PubMed  CAS  Google Scholar 

  • Lehman, J. M., Speers, W. C., Swarzendruber, D. E., and Pierce, G. B., 1974, Neoplastic differentiation: Characteristics of cell lines derived from a murine teratocarcinoma, J. Cell. Physiol. 84: 13–27.

    Article  PubMed  CAS  Google Scholar 

  • Leivo, I., Vaheri, A., Timpl, R., and Wartiovaara, J., 1980, Appearance and distribution of collagens and laminin in the early mouse embryo, Dev. Biol. 76: 100–114.

    Article  PubMed  CAS  Google Scholar 

  • Leivo, I., Alitalo, K., Risteli, L., Vaheri, A., Timpl, R., and Wartiovaara, J., 1982, Basal lamina glycoproteins laminin and type IV collagen assembled into a fine-fibered matrix in cultures of a teratocarcinoma-derived endodermal cell line, Exp. Cell Res. 137: 15–23.

    Article  PubMed  CAS  Google Scholar 

  • Lesot, H., Kuhl, U., and von der Mark, 1983, Isolation of a laminin-binding protein from muscle cell membranes, EMBO J. 2: 861–865.

    PubMed  CAS  Google Scholar 

  • Linzer, D. I., and Levine, A. J., 1979, Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells, Cell 17: 43–52.

    Article  PubMed  CAS  Google Scholar 

  • Liotta, L. A., 1985, Mechanisms of cancer invasion and metastasis, in: Important Advances in Oncology ( V. T. DeVita, S. Hellman, and S. A. Rosenberg, eds.), Lippincott, Philadelphia, pp. 28–41.

    Google Scholar 

  • Liotta, L. A., Kleinerman, J., and Saidel, G. M., 1974, Quantitative relationships of intravascular tumor cells, tumor vessels and pulmonary metastases following tumor implantation, Cancer Res. 34: 997–1004.

    PubMed  CAS  Google Scholar 

  • Liotta, L. A., Gattozzi, C., Kleinerman, J., and Saidel, G., 1977a, Reduction of tumor cell entry into vessels by BCG-activated macrophages, Br. J. Cancer 36: 639–641.

    Article  PubMed  CAS  Google Scholar 

  • Liotta, L. A., Kleinerman, J., Catanzaro, P., and Rynbrandt, D., 19776, Degradation of basement membrane by murine tumor cells, J. Natl. Cancer Inst. 58: 1427–1431.

    Google Scholar 

  • Liotta, L. A., Abe, S., Gehron-Robey, P., and Martin, G. R., 1979, Preferential digestion of basement membrane collagen by an enzyme derived from a metastatic murine tumor, Proc. Natl. Acad. Sci. USA 76: 2268–2274.

    Article  PubMed  CAS  Google Scholar 

  • Liotta, L. A., Tryggvason, K., Garbisa, S., Hart, I., Foltz, C. M., and Shafie, S., 1980, Metastatic potential correlates with enzymatic degradation of basement membrane collagen, Nature 284: 67–68.

    Article  PubMed  CAS  Google Scholar 

  • Liotta, L. A., Goldfarb, R. H., Brundage, R., Siegal, G. P., Terranova, V., and Garbisa, S., 1981a, Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane, Cancer Res. 41: 4629–4636.

    PubMed  CAS  Google Scholar 

  • Liotta, L. A., Goldfarb, R. H., and Terranova, V. P., 1981b, Cleavage of laminin by thrombin and plasmin: Alpha thrombin selectively cleaves the beta chain of laminin, Thromb. Res. 21: 663–673.

    Article  PubMed  CAS  Google Scholar 

  • Liotta, L. A., Lanzer, W. L., and Garbisa, S., 1981c, Identification of a type V collagenolytic enzyme, Biochem. Biophys. Res. Commun. 98: 184–190.

    Article  PubMed  CAS  Google Scholar 

  • Liotta, L. A., Tryggvason, K., Garbisa, S., Gehron-Robey, P., and Abe, S., 1981d, Partial purification and characterization of a neutral protease which cleaves type IV collagen, Biochemistry 20: 100–104.

    Article  PubMed  CAS  Google Scholar 

  • Liotta, L. A., Kalebic, T., Reese, C. A., and Mayne, R., 1982, Protease susceptibilities of HMW 1a, 2a but not 3a cartilage collagens are similar to type V collagen, Biochem. Biophys. Res. Commun. 104: 500–506.

    Article  PubMed  CAS  Google Scholar 

  • Liotta, L. A., Rao, C. N., and Barsky, S. H., 1983, Tumor invasion and the extracellular matrix, Lab. Invest. 49: 636–649.

    PubMed  CAS  Google Scholar 

  • Liotta, L. A., Horan-Hand, P., Rao, C. N., Bryant, G., Barsky, S. II., and Schlom, J., 1985, Monoclonal antibodies to the human laminin receptor recognize distinct structural domains, Exp. Cell Res. 156: 117–126.

    Article  PubMed  CAS  Google Scholar 

  • Loskutoff, D. J., and Edgington, T. E., 1977, Synthesis of a fibrinolytic activator and inhibitor by endothelial cells, Proc. Natl. Acad. Sci. USA 74: 3903–3907.

    Article  PubMed  CAS  Google Scholar 

  • McCroskery, P. A., Richards, J. F., and Harris, E. D., 1975, Purification and characterization of a collagenase extracted from rabbit tumor, Biochem. J. 152: 131–142.

    PubMed  CAS  Google Scholar 

  • Madri, J. A., and Furchtmayr, H., 1979, Isolation and tissue localization of type AB2 collagen from normal lung parenchyma, Am. J. Pathol. 94: 323–331.

    PubMed  CAS  Google Scholar 

  • Madri, J. A., Foellmer, H. G., and Furthmayr, H., 1983, Ultrastructural morphology and domain structure of a unique collagenous component of basement membranes, Biochemistry 22: 2797–2804.

    Article  PubMed  CAS  Google Scholar 

  • Mainardi, C. L., Dixit, S. N., and Kang, A. H., 1980a, Degradation of type IV (basement membrane) collagen by a proteinase isolated from human polymorphonuclear leukocyte granules, J. Biol. Chem. 255: 5435–5441.

    PubMed  CAS  Google Scholar 

  • Mainardi, C. L., Seyer, J. M., and Kang, A. H., 1980b, Type specific collagenolysis: A type V collagen-degrading enzyme from macrophages, Biochem. Biophys. Res. Common. 97: 1108–1115.

    Article  CAS  Google Scholar 

  • Malinoff, H. L., and Wicha, M. S., 1983, Isolation of a cell surface receptor protein for laminin from murine fibrosarcoma cells, J. Cell Biol. 96: 1475–1479.

    Article  PubMed  CAS  Google Scholar 

  • Mareel, M., and de Brabander, M., 1978, Effect of microtubule inhibitors on malignant invasion in vitro, J. Natl. Cancer Inst. 61: 787–792.

    PubMed  CAS  Google Scholar 

  • Mareel, M. M., Kint, J., and Meyvisch, C., 1979, Methods of study of the invasion of malignant C3H mouse fibroblasts into embryonic chick heart in vitro, Virchows Arch. Abt. B. Zellpathol. 30: 95–111.

    CAS  Google Scholar 

  • Markus, G., Takita, H., Camiolo, S. M., Corasanti, J. G., Evers, J. L., and Hobika, G., 1980, Content and characterization of plasminogen activators in human lung tumors and normal lung tissue, Cancer Res. 40: 841–848.

    PubMed  CAS  Google Scholar 

  • Martinez-Hernandez, A., Miller, E. J., Damjanov, I., and Gay, S., 1982, Laminin-secreting yolk sac carcinoma of the rat: Biochemical and electron immunohistochemical studies, Lab. Invest. 47: 247–257.

    PubMed  CAS  Google Scholar 

  • Matsumoto, A., Sakamoto, S., and Sakamoto, M., 1979, Stimulation of bone collagenase synthesis by mouse fibrosarcoma in resorbing bone in vitro culture, Arch. Oral Biol. 24: 403–405.

    Article  PubMed  CAS  Google Scholar 

  • Mayne, R., Vail, M. S., and Miller, E. J., 1978, Characterization of the collagen chains synthesized by cultured smooth muscle cells derived from rhesus monkey thoracic aorta, Biochemistry 17: 446–452.

    Article  PubMed  CAS  Google Scholar 

  • Miller, E. J., and Rhodes, R. K., 1982, Preparation and characterization of the different types of collagen, Meth. Enzymol. 82: 33–64.

    Article  PubMed  CAS  Google Scholar 

  • Minor, R. R., Clark, C. C., Strause, E. L., Koszalka, T. R., Brent, R. L., and Kefalides, N. A., 1976, Basement membrane procollagen is not converted to collagen in organ cultures of parietal yolk sac endoderm, J. Biol. Chem. 251: 1789–1794.

    PubMed  CAS  Google Scholar 

  • Mort, J. S., Recklies, A. D., and Poole, A. R., 1980, Characterization of a thiol proteinase secreted by malignant human breast tumors, Biochim. Biophys. Acta 614: 134–143.

    Article  PubMed  CAS  Google Scholar 

  • Mort, J. S., Leduc, M. S., and Recklies, A. D., 1981, A latent thiol proteinase from ascites fluid of patients with neoplasia, Biochim. Biophys. Acta 662: 173–180.

    Article  PubMed  CAS  Google Scholar 

  • Mort, J. S., Leduc, M. S., and Recklies, A. D., 1983, Characterization of a latent cysteine proteinase from ascitic fluid as a high molecular weight form of cathepsin B, Biochim. Biophys. Acta 755: 369–375.

    Article  PubMed  CAS  Google Scholar 

  • Mott, D. M., Fabisch, P. H., Sani, B. P., and Sorof, S., 1974, Lack of correlation between fibrinolysis and the transformed state of cultured mammalian cells, Biochem. Biophys. Res. Commun. 61: 621–627.

    Article  PubMed  CAS  Google Scholar 

  • Murphy, G., and Sellers, A., 1980, The extracellular regulation of collagenase activity, in: Collagenase in Normal and Pathological Connective Tissue ( D. E. Woolley and J. M. Evanson, eds.), John Wiley and Sons, New York, pp. 65–81.

    Google Scholar 

  • Naito, S., Sueishi, K., Hattori, F., and Tanaka, K., 1980, Immunological analysis of plasminogen activators from cultured human cancer cells, Virchows Arch. Abt. A. Pathol. Anat. Hist. 387: 251–257.

    CAS  Google Scholar 

  • Nakajima, M., Custead, S. E., Welch, D. R., and Nicolson, G. L., 1984, Type IV collagenolysis: Relation to metastatic properties of rat 13762 mammary adenocarcinoma metastatic cell clones, Proceedings of the 75th Annual Meeting of the AACR, Toronto, Canada, p. 62.

    Google Scholar 

  • Neurath, H., and Walsh, K. A., 1976, Role of proteolytic enzymes in biological regulation, Proc. Natl. Acad. Sci. USA 73: 3825–3832.

    Article  PubMed  CAS  Google Scholar 

  • Nicolson, G. L., and Poste, G., 1983, Tumor implantation and invasion of metastatic sites, Int. Rev. Exp. Pathol. 25: 77–181.

    PubMed  CAS  Google Scholar 

  • Nilsson, K., Andersson, L. C., Gahmberg, C. G., and Wigzell, H., 1977, Surface glycoprotein patterns of normal and malignant human lymphoid cells. II. B cells, B blasts, and Epstein—Barr virus (EBV)-positive and -negative B lymphoid cell lines, Int. J. Cancer 20: 708–716.

    Article  PubMed  CAS  Google Scholar 

  • Nowell, P. C., 1976, The clonal evolution of tumor cell populations, Science 194: 23–28.

    Article  PubMed  CAS  Google Scholar 

  • Ooshima, A., 1981, Collagen alpha B chain: Increased proportion in human atherosclerosis, Science 213: 666–668.

    Article  PubMed  CAS  Google Scholar 

  • Orkin, E. R., Gehron-Robey, P., McGoodwin, E. B., Martin, G. R., Valentine, T., and Swarm, R. H., 1977, A murine tumor producing a matrix of basement membrane, J. Exp. Med. 145: 204–220.

    Article  PubMed  CAS  Google Scholar 

  • Orr, F. W., Varani, J., Gondek, M. D., Ward, P. A., and Mundy, G. R., 1980, Partial characterization of a bone-derived chemotactic factor for tumor cells, Am. J. Pathol. 99: 43–52.

    PubMed  CAS  Google Scholar 

  • Ossowski, L., Biegel, D., and Reich, E., 1979, Mammary plasminogen activator: Correlation with involution, hormonal modulation and comparison between normal and neoplastic tissue, Cell 16: 929–940.

    Article  PubMed  CAS  Google Scholar 

  • Pauli, B. U., Memoli, V. A., and Kuettner, K. E., 1981, Regulation of tumor invasion by cartilage-derived anti-invasion factor in vitro, J. Natl. Cancer Inst. 67: 65–73.

    CAS  Google Scholar 

  • Perez-Tamayo, R., 1978, Pathology of collagen degradation: A review, Am. J. Pathol. 92: 508–566.

    PubMed  CAS  Google Scholar 

  • Peterson, H. L., 1968, Experimental studies on fibrinolysis in growth and spread of tumor, Acta. Chir. Scand. Suppl. 134: 394.

    Google Scholar 

  • Peterson, H. L., Kjartansson, I., Korsan-Bengtsen, K., Rudenstam, C. M., and Zettergren, L., 1973, Fibrinolysis in human malignant tumors, Acta. Chir. Scand. 139: 219–223.

    PubMed  CAS  Google Scholar 

  • Plata, F., 1982, Specificity studies of cytolytic T lymphocytes against murine leukemia virus-induced tumors, J. Exp. Med. 155: 1050–1062.

    Article  PubMed  CAS  Google Scholar 

  • Poole, A. R., Tiltman, K. J., Recklies, A. D., and Stoker, T. A. M., 1978, Differences in secretion of the proteinase cathepsin B at the edges of human breast carcinomas and fibroadenomas, Nature 273: 545–547.

    Article  PubMed  CAS  Google Scholar 

  • Poste, G., Doll, J., and Fidler, I. J., 1981, Interactions among clonal subpopulations affect stability of the metastatic phenotype in polyclonal populations of B16 melanoma cells, Proc. Natl. Acad. Sci. USA 78: 6226–6230.

    Article  PubMed  CAS  Google Scholar 

  • Poste, G., Greig, R., Tzong, J., Koestler, T., and Corwin, S., 1984, Interactions between tumor cell subpopulations in malignant tumors, in: Cancer Invasion and Metastasis: Biologic and Therapeutic Aspects ( G. L. Nicolson and L. Milas, eds.), Raven Press, New York, pp. 223–243.

    Google Scholar 

  • Quigley, J. P., 1979a, Phorbol ester-induced morphological changes in transformed chick fibroblasts: Evidence for direct catalytic involvement of plasminogen activator, Cell 17: 131–141.

    Article  PubMed  CAS  Google Scholar 

  • Quigley, J. P., 19796, Proteolytic enzymes of normal and malignant cells, in: Surfaces of Normal and Malignant Cells (R. O. Hynes, ed.), Wiley, New York, pp. 247–285.

    Google Scholar 

  • Rao, C. N., Margulies, I. M., Goldfarb, R. H., Madri, J. A., Woodley, D. T., and Liotta, L. A., 1982a, Differential proteolytic susceptibility of laminin alpha and beta subunits, Arch. Biochem. Biophys. 219: 65–70.

    Article  PubMed  CAS  Google Scholar 

  • Rao, C. N., Margulies, I. M., Tralka, T. S., Terranova, V. P., Madri, J., and Liotta, L. A., 19826, Isolation of a subunit of laminin and its role in molecular structure and tumor cell attachment, J. Biol. Chem. 257: 9740–9744.

    Google Scholar 

  • Rao, C. N., Barsky, S. H., Terranova, V. P., and Liotta, L. A., 1983a, Isolation of a tumor cell laminin receptor, Biochem. Biophys. Res. Commun. 11: 804–808.

    Article  Google Scholar 

  • Rao, C. N., Goldstein, I. J., and Liotta, L. A., 1983b, Lectin-binding domains on laminin, Arch. Biochem. Biophys. 227: 118–124.

    Article  PubMed  CAS  Google Scholar 

  • Raz, A., and Geiger, B., 1982, Altered organization of cell—substrate contacts and membrane-associated cytoskeleton in tumor cell variants exhibiting different metastatic capabilities, Cancer Res. 42: 5183–5190.

    PubMed  CAS  Google Scholar 

  • Recklies, A. D., and Poole, A. R., 1982, Proteolytic mechanisms of tissue destruction in tumor growth and metastasis, in: Liver Metastasis ( L. Weiss and H. A. Gilbert, eds.), G. K. Hall, Boston, pp. 77–95.

    Google Scholar 

  • Recklies, A. D., Tiltman, K. J., Stoker, A. M., and Poole, A. R., 1980, Secretion of proteinases from malignant and nonmalignant human breast tissue, Cancer Res. 40: 550–556.

    PubMed  CAS  Google Scholar 

  • Recklies, A. D., Poole, A. R., and Mort, J. S., 1982, A cysteine proteinase secreted from human breast tumours is immunologically related to cathepsin B, Biochem. J. 207: 633–636.

    PubMed  CAS  Google Scholar 

  • Reich, E., 1978, Activation of plasminogen: A widespread mechanismm for generating localized extracellular proteolysis, in: Biological Markers for Neoplasia: Basic and Applied Aspects ( R. W. Ruddon, ed.), Elsevier, Amsterdam, pp. 491–500.

    Google Scholar 

  • Reich, N., and Levine, A. J., 1982, Specific interaction of the SV40 T antigen—cellular p53 protein complex with SV40 DNA, Virology 117: 286–290.

    Article  PubMed  CAS  Google Scholar 

  • Rhodes, R. K., and Miller, E. J., 1978, Physicochemical characterization and molecular organization of the collagen A and B chains, Biochemistry 17: 3442–3448.

    Article  PubMed  CAS  Google Scholar 

  • Rifkin, D. B., Loeb, J. N., Moore, G., and Reich, E., 1974, Properties of plasminogen activators formed by neoplastic human cell cultures, J. Exp. Med. 139: 1317–1328.

    Article  PubMed  CAS  Google Scholar 

  • Robertson, J. D., and Black, P. H., 1969, Changes in surface antigens of SV40 virus-transformed cells, Proc. Soc. Exp. Biol. Med. 130: 363–370.

    PubMed  CAS  Google Scholar 

  • Rohrschneider, L. R., 1980, Adhesion plaques of Rous sarcoma virus-transformed cells contain the src gene product, Proc. Natl. Acad. Sci. USA 77: 3514–3518.

    Article  PubMed  CAS  Google Scholar 

  • Rohrschneider, L. R., Rosok, M., and Schriver, K., 1982, Mechanism of transformation by Rous sarcoma virus: Events within adhesion plaques, Cold Spring Harbor Conf. Cell Prolif. 46: 953–965.

    Google Scholar 

  • Romualdez, A. G., and Ward, P. A., 1975, A unique complement derived chemotactic factor for tumor cells, Proc. Natl. Acad. Sci. USA 72: 4128–4132.

    Article  PubMed  Google Scholar 

  • Roughley, P. J., and Barrett, A. J., 1977, The degradation of cartilage proteoglycans by tissue proteinases: Proteoglycan structure and its susceptibility to proteolysis, Biochem. J. 167: 629–637.

    PubMed  CAS  Google Scholar 

  • Sage, H., Pritzl, P., and Bornstein, P., 1981, Characterization of cell matrix associated collagens synthesized by aortic endothelial cells in culture, Biochemistry 20: 436–442.

    Article  PubMed  CAS  Google Scholar 

  • Sakashita, S., and Ruoslahti, E., 1980, Basement membrane glycoprotein laminin binds to heparin or laminin-like glycoproteins in extracellular matrix of endodermal cells, Arch. Biochem. Biophys. 205: 283–290.

    Article  PubMed  CAS  Google Scholar 

  • Salo, T., Liotta, L. A., Keski-Oja, J., Turpeenniemi-Hujanen, T., and Tryggvason, K., 1982, Secretion of basement membrane collagen degrading enzyme and plasminogen activator by transformed cells: Role in metastasis, Int. J. Cancer 30: 669–673.

    Article  PubMed  CAS  Google Scholar 

  • Salo, T., Liotta, L. A., and Tryggvason, K., 1983, Purification and characterization of a murine basement membrane collagen degrading enzyme secreted by metastatic tumor cells, J. Biol. Chem. 258: 3058–3063.

    PubMed  CAS  Google Scholar 

  • Sasaki, M., Peterson, J. A., Wara, W. M., and Ceriani, R. L., 1981, Human mammary epithelial antigens (HME-Ags) in the circulation of nude mice implanted with a breast tumor and non-breast tumors, Cancer 48: 2204–2210.

    Article  PubMed  CAS  Google Scholar 

  • Schirrmacher, V., 1980, Shifts in tumor cell phenotypes induced by signals from the microenvironment: Relevance for the immunobiology of cancer metastasis, Immunobiology 157: 89–98.

    Article  PubMed  CAS  Google Scholar 

  • Schirrmacher, V., and Waller, C. A., 1982, Quantitative determination of disseminated tumor cells by ‘H thymidine incorporation in vitro by agar colony formation, Cancer Res. 42: 660–666.

    PubMed  CAS  Google Scholar 

  • Sears, H. F., Herlyn, M., Del Villano, B., Steplewski, Z., and Koprowski, H., 1982, Monoclonal antibody detection of a circulating tumor-associated antigen. II. A longitudinal evaluation of patients with colorectal cancer, J. Clin. Immunol. 2: 141–149.

    Article  PubMed  CAS  Google Scholar 

  • Sefton, B. M., and Rubin, H., 1970, Release from density dependent growth inhibition by proteolytic enzymes, Nature 227: 843–845.

    Article  PubMed  CAS  Google Scholar 

  • Shamberger, R. J., and Rudolph, G., 1967, Increase of lysosomal enzymes in skin cancers, Nature 213: 617–618.

    Article  PubMed  CAS  Google Scholar 

  • Showell, H. J., Freer, R. J., Zigmond, S. H., Schiffmann, E., Aswanikumaar, S., Corcoran, B., and Becker, E. L., 1976, The structure activity relationship of synthetic peptides as chemotactic factors and inducers of lysosomal enzyme secretion for neutrophils, J. Exp. Med. 143: 1154–1169.

    Article  PubMed  CAS  Google Scholar 

  • Siegal, G. P., Thorgeirsson, U. P., Russo, R. G., Wallace, D. M., Liotta, L. A., and Berger, S. L., 1982, Interferon enhancement of the invasive capacity of Ewing sarcoma cells in vitro, Proc. Natl. Acad. Sci. USA 79: 4064–4068.

    Article  PubMed  CAS  Google Scholar 

  • Sloane, B. F., Dunn, J. R., and Honn, K. V., 1981, Lysosomal cathepsin B: Correlation with metastatic potential, Science 212: 1151–1153.

    Article  PubMed  CAS  Google Scholar 

  • Sloane, B. F., Honn, K. V., Sadler, J. G., Turner, W. A., Kimpson, J. J., and Taylor, J. D., 1982, Cathepsin B activity in B16 melanoma cells: A possible marker for metastatic potential, Cancer Res. 42: 980–986.

    PubMed  CAS  Google Scholar 

  • Smith, J. B., and O’Neill, R. T., 1971, Fetal gut antigen: A substance in fetal gut and its relationship to gut carcinoma, Commun. Chem. Pathol. Pharmacol. 2: 1–15.

    CAS  Google Scholar 

  • Steck, P. A., Luna, M. A., and Nicolson, G. L., 1984, Analysis of cell surface sialogalactoprotein isolated from lung metastases of rat 137562 NF and human mammary adenocarcinoma, Proceedings of the 75th Annual Meeting of the AACR, Toronto, Canada, p. 55.

    Google Scholar 

  • Stenn, K. S., Madri, J. A., and Roll, F. J., 1979, Migrating epidermis produces AB2 collagen and requires continual collagen synthesis for movement, Nature 277: 229–232.

    Article  PubMed  CAS  Google Scholar 

  • Sträuli, P., 1980, A concept of tumor invasion, in: Proteinases and Tumor Invasion ( P. Strauli, A. J. Barrett, and A. Baici, eds.), Raven Press, New York, pp. 1–15.

    Google Scholar 

  • Strickland, S., Reich, E., and Sherman, E., 1976, Plasminogen activator in early embryogenesis: Enzyme production by trophoblast and parietal endoderm, Cell 9: 231–240.

    Article  PubMed  CAS  Google Scholar 

  • Strickland, S., Smith, K. K., and Marotti, K. R., 1980, Hormonal induction of differentiation in teratocarcinoma stem cells: Generation of parietal endoderm by retinoic acid and dibutyryl cAMP, Cell 21: 347–355.

    Article  PubMed  CAS  Google Scholar 

  • Stricklin, G. P., Bauer, E. A., Jeffrey, J. J., and Eisen, A. Z., 1977, Human skin collagenase: Isolation of precursor and active forms from both fibroblast and organ cultures, Biochemistry 16: 1607–1615.

    Article  PubMed  CAS  Google Scholar 

  • Sylven, B., 1974, Biochemical factors involved in the cellular detachment from tumors, Schweiz. Med. Wochenschr. 104: 258–261.

    CAS  Google Scholar 

  • Tagnon, H. J., Whitmore, W. F., and Shulman, N. R., 1952, Fibrinolysis in metastatic cancer of the prostate, Cancer 5: 9–12.

    Article  PubMed  CAS  Google Scholar 

  • Tal, C., 1965, The nature of the cell membrane receptor for the agglutination factor present in the sera of tumor patients and pregnant women, Proc. Natl. Acad. Sci. USA 54: 1318–1321.

    Article  PubMed  CAS  Google Scholar 

  • Talmadge, J. E., Starkey, J. R., Davis, W. C., and Cohen, A. L., 1979, Introduction of metastatic heterogeneity by short-term in vivo passage of a cloned transformed cell line, J. Supramol. Struct. 12: 227–243.

    Article  PubMed  CAS  Google Scholar 

  • Talmadge, J. E., Kay, M. E., and Hart, I. R., 1981, Characterization of a murine ovarian reticulum cell sarcoma of histiocytic origin, Cancer Res. 41: 1271–1280.

    PubMed  CAS  Google Scholar 

  • Terranova, V. P., Rohrbach, D. H., and Martin, G. R., 1980, Role of laminin in the attachment of PAM 212 (epithelial) cells to basement membrane collagen, Cell 22: 719–726.

    Article  PubMed  CAS  Google Scholar 

  • Terranova, V. P., Liotta, L. A., Russo, R. G., and Martin, G. R., 1982, Role of laminin in the attachment and metastasis of murine tumor cells, Cancer Res. 42: 2265–2269.

    PubMed  CAS  Google Scholar 

  • Terranova, V. P., Rao, C. N., Kalebic, T., Margulies, I. M., and Liotta, L. A., 1983, Laminin receptor on human breast carcinoma cells, Proc. Natl. Acad. Sci. USA 80: 444–448.

    Article  PubMed  CAS  Google Scholar 

  • Thorgeirsson, U. P., Liotta, L. A., Kalebic, T., Margulies, I. M., Themas, K., Rios-Candelore, M., and Russo, R. G., 1982, Effect of natural protease inhibitor and a chemoattractant on tumor cell invasion in vitro, J. Natl. Cancer Inst. 69: 1049–1054.

    PubMed  CAS  Google Scholar 

  • Thorgeirsson, U. P., Turpeenniemi-Hujanen, T., Neckers, L., Johnson, D. W., and Liotta, L. A., 1984, Protein synthesis but not DNA synthesis is required for tumor cell invasion in vitro, Invas. Met. 4: 73–83.

    CAS  Google Scholar 

  • Timpl, R., Martin, G. R., Bruckner, P., Wick, G., and Widermann, H., 1978, Nature of the collagenous protein in a tumor basement membrane, Eur. J. Biochem. 84: 43–52.

    Article  PubMed  CAS  Google Scholar 

  • Timpl, R., Rohde, H., Gehron-Robey, P., Rennard, S., Foidart, J. M., and Martin, G. R., 1979, Laminin—A glycoprotein from basement membranes, J. Biol. Chem. 254: 9933–9937.

    PubMed  CAS  Google Scholar 

  • Timpl, R., Oberbaumer; I., Furthmayr, H., and Kühn, K., 1982a, Macromolecular organization of type IV collagen, in: New Trends in Basement Membrane Research ( K. Kühn, H. Schöne, and R. Timpl, eds.), Raven Press, New York, pp. 57–67.

    Google Scholar 

  • Timpl, R., Rohde, H., Risteli, L., Ott, U., Gehron-Robey, P., and Martin, G. R., 1982b, Laminin, Meth. Enzvmol. 82: 831–838.

    Article  CAS  Google Scholar 

  • Todaro, G. J., Green, H., and Goldberg, B. D., 1964, Transformation of properties of an established cell line by SV40 and polyoma virus, Proc. Natl. Acad. Sci. USA 51: 66–73.

    Article  PubMed  CAS  Google Scholar 

  • Troll, W., Klassen, A., and Janoff, A., 1970, Tumorigenesis in mouse skin: Inhibition by synthetic inhibitors of proteases, Science 169: 1211–1213.

    Article  PubMed  CAS  Google Scholar 

  • Tryggvason, K., Gehron-Robey, P., and Martin, G., 1980, Biosynthesis of type IV procollagens, Biochemistry 19: 1284–1289.

    Article  PubMed  CAS  Google Scholar 

  • Tucker, W. S., Kirsch, W. M., Martinez-Hernandez, A., and Fink, L. M., 1978, In vitro plasminogen activator activity in human brain tumors, Cancer Res. 38: 297–302.

    PubMed  CAS  Google Scholar 

  • Turpeenniemi-Hujanen, T., Thorgeirsson, U. P., and Liotta, L. A., 1984, Collagenases in tumor cell extravasation, Annu. Rep. Med. Chem. 19: 231–239.

    Article  CAS  Google Scholar 

  • Unkeless, J. C., Tobia, A., Ossowski, L., Quigley, J. P., Rifkin, D. B., and Reich, E., 1973, An enzymatic function associated with transformation of fibroblasts by oncogenic viruses. I. Chick embryo fibroblast cultures transformed by avian RNA tumor viruses, J. Exp. Med. 137: 85–111.

    Article  PubMed  CAS  Google Scholar 

  • Van Herendael, B. J., Oberti, C., Brosens, I., 1978, Microanatomy of the human amniotic membranes, Am. J. Obstet. Gynecol. 131: 872–880.

    PubMed  Google Scholar 

  • Varani, J., and Ward, P. A., 1982, Tumor cell chemotaxis, in: Tumor Invasion and Metastasis ( L. A. Liotta and I. R. Hart, eds.), Martinus Nijhoff, The Hague, pp. 99–112.

    Chapter  Google Scholar 

  • Varani, J., Orr, W., and Ward, P. A., 1979, Cell-associated proteases affect tumor cell migration in vitro, Cancer Res. 39: 2376–2380.

    PubMed  CAS  Google Scholar 

  • Varani, J., Wass, J., Piontek, G., and Ward, P. A., 1981, Chemotactic factor-induced adherence of tumor cells, Cell. Biol. Int. Rep. 5: 525–530.

    Article  PubMed  CAS  Google Scholar 

  • Vlodaysky, I., Lui, G. M., and Gospodarowicz, D., 1980, Morphological appearance, growth behavior and migratory activity of human tumor cells maintained on extracellular matrix versus plastic, Cell 19: 607–616.

    Article  Google Scholar 

  • Vracko, P., 1974, Basal lamina scaffold—Anatomy and significance for maintenance of orderly tissue structure, Am. J. Pathol. 77: 314–346.

    PubMed  CAS  Google Scholar 

  • Wang, E., and Goldberg, A. R., 1976, Changes in microfilament organization and surface topography upon transformation of chick embryo fibroblasts with Rous sarcoma virus, Proc. Natl. Acad. Sci. USA 457: 4065–4069.

    Article  Google Scholar 

  • Wass, J. A., Varani, J., and Ward, P. A., 1980, Size increase induced in Walker ascites cells by chemotactic factors, Cancer Lett. 9: 313–318.

    Article  PubMed  CAS  Google Scholar 

  • Wass, J. A., Varandi, J., Pionter, G. E., Goff, D., and Ward, P. A., 1981, Characteristics of the chemotactic factor-mediated cell swelling response of tumor cells, J. Natl. Cancer Inst. 66: 927–933.

    PubMed  CAS  Google Scholar 

  • Watanabe, H., 1974, Purification and chemical characterization of a-fetoprotein from rat and mouse, Int. J. Cancer 13: 377–388.

    Article  Google Scholar 

  • Webber, M. M., James, G., Lucero, L., Van Buskirk, J. J., and Wettlaufer, J. M., 1981, Plasminogen activator: A marker for human prostatic epithelium and prostate cancer, In Vitro 17: 249.

    Google Scholar 

  • Weiss, L., 1980, Cancer cell traffic from the lungs to the liver: An example of metastatic inefficiency, Int. J. Cancer 25: 385–392.

    Article  PubMed  CAS  Google Scholar 

  • Weiss, L., Mayhew, E., Rapp, D. G., and Holmes, J., 1982, Metastatic inefficiency in mice bearing B16 melanomas, Br. J. Cancer 45: 44–53.

    Article  PubMed  CAS  Google Scholar 

  • Welgus, H. G., Jeffrey, J. J., and Eisen, A. Z., 1981, The collagen substrate specificity of human skin fibroblast collagenase, J. Biol. Chem. 256: 9511–9515.

    PubMed  CAS  Google Scholar 

  • Welsh, C., Gay, S., Rhodes, R. K., Pfister, R., and Miller, E. J., 1980, Collagen heterogeneity in normal rabbit cornea. I. Isolation and biochemical characterization of the genetically-distinct collagens, Biochim. Biophys. Acta 625: 78–88.

    Article  PubMed  CAS  Google Scholar 

  • Wewer, U., Albrechtsen, R., and Ruoslahti, E., 1981, Laminin: A noncollagenous component of epithelial basement membranes synthesized by a rat yolk sac tumor, Cancer Res. 41: 1518–1524.

    PubMed  CAS  Google Scholar 

  • Wicha, M. S., and Huard, T. K., 1983, Macrophages express cell surface laminin, Exp. Cell Res. 143: 475–479.

    Article  PubMed  CAS  Google Scholar 

  • Wigler, M., and Weinstein, I. B., 1976, Tumour promotor induces plasminogen activator, Nature 259: 232–233.

    Article  PubMed  CAS  Google Scholar 

  • Willingham, M. C., Jay, G., and Pastan, I., 1979, Localization of the ASV src gene product to the plasma membrane of transformed cells by electron microscopic immunocytochemistry, Cell 18: 125–134.

    Article  PubMed  CAS  Google Scholar 

  • Wilson, E. L., and Dowle, E., 1978, Secretion of plasminogen activator by normal, reactive and neoplastic human tissues cultured in vitro, Int. J. Cancer 22: 390–399.

    Article  PubMed  CAS  Google Scholar 

  • Wilson, E. L., and Reich, E., 1978, Plasminogen activator in chick fibroblasts: Induction of synthesis by retinoic acid; synergism with viral transformation and phorbol ester, Cell 15: 385–392.

    Article  PubMed  CAS  Google Scholar 

  • Wolf, B. A., and Goldberg, A. R., 1976, Rous-sarcoma-virus-transformed fibroblasts having low levels of plasminogen activator, Proc. Natl. Acad. Sci. USA 73: 3613–3617.

    Article  PubMed  CAS  Google Scholar 

  • Woolley, D. E., and Grafton, C. A., 1980, Collagenase immunolocalization studies of cutaneous secondary melanomas, Br. J. Cancer 42: 260–265.

    Article  PubMed  CAS  Google Scholar 

  • Woolley, D. E., Roberts, D. R., and Evanson, J. M., 1975, Inhibition of human collagenase activity by a small molecular weight serum protein, Biochem. Biophys. Res. Commun. 66: 747–754.

    Article  PubMed  CAS  Google Scholar 

  • Woolley, D. E., Glanville, R. W., Roberts, D. R., and Evanson, J. M., 1978, Purification, characterization and inhibition of human skin collagenase, Biochem. J. 169: 265–276.

    PubMed  CAS  Google Scholar 

  • Yamanishi, Y., Dabbous, M. K., and Hashimoto, K., 1972, Effect of collagenolytic activity in basal cell epithelioma of the skin on reconstituted collagen and physical properties and kinetics of the crude enzyme, Cancer Res. 32: 2551–2560.

    PubMed  CAS  Google Scholar 

  • Yamauchi, K., Fujimoto, S., and Tada, T., 1979, Differential activation of cytotoxic and suppressor T cells against syngeneic tumors in the mouse, J. Immunol. 123: 1653–1658.

    PubMed  CAS  Google Scholar 

  • Yogeeswaran, G., and Salk, P. S., 1981, Metastatic potential is positively correlated with cell surface sialylation of cultured murine tumor cell lines, Science 212: 1514–1516.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20205, USA

    Unnur P. Thorgeirsson, Taina Turpeenniemi-Hujanen & Lance A. Liotta

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  1. Unnur P. Thorgeirsson
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  2. Taina Turpeenniemi-Hujanen
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  3. Lance A. Liotta
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  1. Grace Cancer Drug Center, Roswell Park Memorial Institute, Buffalo, New York, USA

    Enrico Mihich

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© 1985 Plenum Press, New York

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Thorgeirsson, U.P., Turpeenniemi-Hujanen, T., Liotta, L.A. (1985). Mechanisms of Tumor Invasion and Their Potential Therapeutic Modifications. In: Mihich, E. (eds) Biological Responses in Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1236-9_2

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  • DOI: https://doi.org/10.1007/978-1-4684-1236-9_2

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