Abstract
A consideration of the chemotherapy of trematode infections of man will invariably be unevenly distributed with respect to the parasites involved. The great preponderance of attention must be devoted to the blood flukes or schistosomes, because of their great medical importance and because so much is known about their treatment. The remaining flukes, having various degrees of medical importance and having a lesser body of therapeutic lore, can be covered more briefly.
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Ambroise-Thomas P. Goullier A. and Peyron F. 1984 Therapeutic results in opisthorchiasis with praziquantel in a reinfection-free environment in France Arzneimittelforsch. 34 II): 1177–117
Abaza, H. H., Hammouda, N., Abd Rabbo, H., and Shafei, A. Z., 1978, Chemotherapy of schistosomal colonic polyposis with oxamniquine, Trans. R. Soc. Trop. Med. Hyg. 72:602–604.
Bennett, J. K., and Depenbusch, J. W., 1984, The chemotherapy of schistosomiasis, in: Parasitic Diseases, Vol. 2: The Chemotherapy (J. M. Mansfield, ed.), pp. 73–131, Dekker, New York.
Bunnag, D., Pungpark, S., Harinasuta, T., Viravan, C., Vanijanonta, S., Suntharasamai, P., Migasena, S., Charoenlarp, P., Riganti, M., and LooAreesuwan, S., 1984, Opisthorchis viverrini: Clinical experience with praziquantel in hospital for tropical diseases, Arzneimittelforsch. 34(11): 1173–1174.
Campbell, W. C., and Cuckler, A. C., 1961, The prophylactic effect of topically applied cedarwood oil on infection with Schistosoma mansoni in mice, Am. J. Trop. Med. Hyg. 10:712–715.
Campbell, W. C., and Cuckler, A. C., 1967, Inhibition of egg production of Schistosoma mansoni in mice treated with nicarbazin, J. Parasitol. 53:977–980.
Campbell, W. C., and Rogers, E. F., 1971, Effect of nitrocarbanilides on Schistosoma mansoni, J. Parasitol. 57:1372–1373.
Campbell, W. C, Bartels, E., and Cuckler, A. C, 1978, A method for detecting chemotherapeutic activity against Schistosoma mansoni in mice, J. Parasitol. 64:69–77.
Cao, W. J., He, L. Y., Zhong, H. L. Chung, H. L., Xu, Z. S., Bi, Y. C., Yu, G. T., Zhang, Q. C., Li, K. C., Yang, E. V., She, G., and Li, H. J., 1984, Paragonimiasis: Treatment with praziquantel in 40 human cases and in 1 cat, Arzneimittelforsch. 34(II): 1203–1204.
Chen, C. Y., and Hsieh, W. C., 1984, Clonorchis sinensis: Epidemiology in Taiwan and clinical experience with praziquantel, Arzneimittelforsch. 34(II): 1160–1162.
Chen, M. G., Hua, X. J., Wan, Z. R., Weng, Y. Q., Wang, M. J., Zhu, P. J., He, B. Z., and Xu, M. Y., 1983, Praziquantel in 237 cases of clonorchiasis sinensis, Chin. Med. J. 96:935–940 (English transi.).
Cho, S. Y., Kang, S. Y., and Lee, J. B., 1984, Metagonimiasis in Korea, Arzneimittelforsch. 34(II): 1211–1213.
Davis, A., 1982, Manage of the patient in schistosomiasis, in: Schistosomiasis (P. Jordan and G. Webbe, eds.), pp. 184–226, Heineman Medical Books, London.
Davis, A., and Bailey, D. R., 1969, Metrifonate in urinary schistosomiasis, Bull. WHO 41:209–224.
Davis, A., and Wegner, D. H. G., 1979, Multicenter trials of praziquantel in the treatment of human schistosomiasis: Designs and techniques, Bull. WHO 51:767–772.
Davis, A., Biles, J. E., and Wrich, A. M., 1979, Initial experience with praziquantel in the treatment of human infection due to Schistosoma haematobium, Bull. WHO 57:773–780.
Delolme, H., Cot, M., Cavallo, A., Kouka-Bemba, D., and Sentilhes, L., 1983, Réflexions sur le traitement de masse des bilharzioses à Schistosoma haematobium dans les états membres de l’Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC), Bull. Soc. Pathol. Exot Fil. 76:534–541.
de Souza Dias, L. C. S., Pedro, R. V., and Deberaldini, E. R., 1982, Use of praziquantel in patients with schistosomiasis mansoni previously treated with oxamniquine and/or hycanthone: Resistance of Schistosoma mansoni to schistosomicidal agents, Trans. R. Soc. Trop. Med. Hyg. 76:652–659.
Dhiensiri, T., Eua-Ananta, Y., Bunnag, D., Harinasuta, T., and Schelp, P. F., 1984, Roentgenographically controlled healing of gallbladder lesions in opisthorchiasis after praziquantel treatment, Arzneimittelforsch. 34(II):1175–1177.
Doehring, E., Feldmeier, H., Dafalla, A. A., Ehrich, J. H., Vester, U., and Poggensee, U., 1984, Intermittent chemotherapy with trichlorfon (metrifonate) reverses proteinuria, hematuria, and leukocyturia in urinary schistosomiasis: Results of a three–year field study, J. Infect. Dis. 149:615–620.
Feldmeier, H., Doehring, E., Daffala, A. A., Omer, A. H. S., and Dietrich, M., 1981, Efficacy of metrifonate in urinary schistosomiasis in light and heavy infections, Tropenmed. Parasitol. 33:102–106.
Feldmeier, H., Doehring, E., Daffala, A. A., Omer, A. H. S., and Dietrich, M., 1982, Efficacy of metrifonate in urinary schistosomiasis: Comparison of reduction of Schistosoma haematobium and S. mansoni eggs, Am.J. Trop. Med. Hyg. 31:1188–1194.
Foster, R., and Cheetham, B. L., 1973, Studies with the schistosomicide oxamniquine (UK4271) I, Trans. R. Soc. Trop. Med. Hyg. 67:674–684.
Friedheim, E. A. H., 1973, Chemotherapy of schistosomiasis, in: Chemotherapy of Helminthiasis (R. Cavier and F. Hawking, eds.), pp. 29–144, Pergamon Press, Oxford.
Frohberg, H., 1984, Results of toxicological studies on praziquantel, Arzneimittelforsch. 34(11): 1137–1144.
Fu, S., Zhou, X. Z., and Fan, Y., 1983, Comparative study on different dose schedules of praziquantel in the treatment of schistosomiasis japonica, J. Parasitol. Parasitic Dis. 1:32–36.
Gilbert, B., DeSouza, J. P., Fortes, C. C, DosSantos, F., DoPrado Seabra, A., Kitagawa, M., and Pellegrino, J., 1970, Chemoprophylactic agents in schistosomiasis: Active and inactive terpenes, J. Parasitol. 56:397–398.
Gonnert, R., and Andrews, P., 1977, Praziquantel, a new broad-spectrum antischistosomal agent, Z. Parasitenk. 52:129–150.
Greene, L. K., Grenan, M. M., Davidson, D. E., Jr., Jones, D. H., and Shedd, T. R., 1983, Amoscanateas a topically applied chemical for prophylaxis against Schistosoma mansoni infections in mice, Am. J. Trop. Med. Hyg. 32:1356–1363.
Harinasuta, T., Bunnag, D., and Radomyos, P., 1984, Efficacy of praziquantel on fasciolopsiasis, Arzneimittelforsch. 34(II):1214–1215.
Horstmann, R. D., Feldheim, W., Feldmeier, H., and Dietrich, M., 1981, High efficacy of praziquantel in the treatment of 22 patients with Clonorchis/Opisthorchis infections, Tropenmed. Parasitol. 32:157–160.
Ishizaki, T., Kamo, E., and Boelone, E., 1979, Double-blind studies of tolerance to praziquantel in Japanese patients with Schistosoma japonicum infection, Bull. WHO 57:787–792.
Islip, P. J., 1973, Progress in the experimental chemotherapy of helminth infections, Fortschr. Arzneimittelforsch. 17:241–319.
Jackson, H., Davies, P., and Bock, M., 1968, Chemosterilization of Schistosoma mansoni, Nature (Lond.) 218:977.
James, C., Webbe, G., and Nelson, G. S., 1977, The susceptibility to praziquantel of Schistosoma haematobium in the baboon (Papio anubis) and of S. japonicum in the vervet monkey (Cercopithecus aethiops), Z. Parasitenk. 52:1179–1194.
Johnson, R. J., Dunning, S. B., Minshew, B. H., and Jong, E. C., 1983, Successful praziquantel treatment of paragonimiasis following bithionol failure, Am.J. Trop. Med. Hyg. 32:1309–1311.
Katz, N., and Pellegrino, J., 1974, Experimental chemotherapy of schistosomiasis mansoni, Adv. Parasitol. 12:369–390.
Katz, N., Zicker, F., and Pereira, J. P., 1977, Field trials with oxaminiquine in schistosomiasis mansoniendemic area, Am. J. Trop. Med. Hyg. 26:234–237.
Katz, N., Rocha, R. S., and Chaves, A., 1979, Preliminary trials with praziquantel in human infections due to Schistosoma mansoni, Bull. WHO 57:781–786.
Katz, N., Rocha, R. S., and Chaves, A., 1981, Clinical trials with praziquantel in Schistosoma mansoni, Rev. Inst. Med. Trop. Sao Paulo 23:72–78.
Kern, P., Burchard, G. D., and Deitrich, M., 1984, Comparative study of oltipraz versus praziquantel for treatment of schistosomiasis with intestinal manifestation in the Gabon (Schistosoma intercalatum and S. haematobium), Tropenmed. Parasitol. 35:95–99.
Kilpatrick, M. E., El Masry, N. A., Bassily, S., and Farid, Z., 1982, Oxamniquine versus niridazole for treatment of uncomplicated Schistosoma mansoni infection, Am. J. Trop. Med. Hyg. 31:1164–1167.
Krajden, S., Keystone, J. S., and Glenn, C., 1983, Safety and toxicity of oxamniquine in the treatment of Schistosoma mansoni infections, with particular reference to electroencephalographic abnormalities, Am.J. Trop. Med. Hyg. 32:1344–1346.
Kuang, Q. H., Zhou, Y. T., Lei, S. Z., Cao, W. J., and Zhong, H. L. Chung, H. L., 1984, Clonorchiasis: Treatment with Praziquantel in 50 cases, Arzneimittelforsch. 34:(II): 1162–1163.
Lambertucci, J. R., Greco, D. B., Pedroso, E. R. P., Rocha, M. O. D., Salazar, H-M, and DeLima, D. P., 1982, A double blind trial with oxamniquine in chronic schistosomiasis mansoni, Trans. R. Soc. Trop. Med. Hyg. 76:751–755.
Lammler, G., 1968, Chemotherapy of trematode infections, in: Advances in Chemotherapy (A. Goldin, F. Hawking, and R. J. Schnitzer, eds.), pp. 153–251, Academic Press, New York.
Lapierre, J., Keita, A., Faurant, C., Heyer, F., Tourte-Schaefer, C., Ancelle, T., and Dupouy-Camet, J., 1983, Treatment of 700 cases of bilharziasis with the new drugs oxamniquine, oltipraz, praziquantel, Bull. Soc. Pathol. Exot. Fil. 76:526–533.
Le, W. J., You, J. Q., and Mei, J. Y., 1983, Chemotherapeutic effect of artesunate in experimental schistosomiasis, Yao Hsueh Hsueh Pao 18:619–621.
Lee, S. H., 1984, Large scale treatment of Clonorchis sinensis infections with praziquantel under field conditions, Arzneimittelforsch. 34(11): 1227–1230.
Legator, M. S., Connor, T. H., and Stoeckel, M., 1975, Detection of mutagenic activity of metronidazole and niridazole in body fluids of humans and mice, Science 188:1118–1119.
Mahmoud, A. A. F., Siongok, T. K. A., Ouma, J., Houser, H. B., and Warren, K. S., 1983, Effect of targeted mass treatment on intensity of infection and morbidity in schistosomiasis mansoni, Lancet 1:849–851.
Mason, P. R., and Tswana, S. A., 1984, Single-dose metrifonate for the treatment of Schistosoma haematobium infection in an endemic area of Zimbabwe, Am. J. Trop. Med. Hyg. 33:599–601.
McMahon, J. E., 1976, Oxamniquine (UK4271) in Schistosoma haematobium infections, Ann. Trop. Med. Parasitol. 70:121–122.
McMahon, J. E., 1983, A comparative trial of praziquantel, metrifonate and niridazole against Schistosoma haematobium, Am. Trop. Med. Parasitol. 77:139–142.
Minggang, C., Sui, F., Xiangjin, H., and Huimin, W., 1984, A retrospective survey on side effects of praziquantel among 25693 cases of schistosomiasis japonica, Southeast Asian J. Trop. Med. Publ. Health 14:495–500.
Monson, M. H., Koenig, J. W., and Sachs, R., 1983, Successful treatment with praziquantel of six patients infected with the African lung fluke, Paragonimus uterobilateralis, Am.J. Trop. Med. Hyg. 32:371–375.
Muftic, M., 1970, New methods for testing schistosomicidal drugs, J. Trop. Med. Hyg. 73:232–234.
Nash, T. E., Hofstetter, M., Cheeves, A. W., and Ottesen, E. A., 1982, Treatment of Schistosoma mekongi with praziquantel: A double-blind study, Am. J. Trop. Med. Hyg. 31:977–982.
Omer, A. H. S., and Teesdale, C. H., 1978, Metrifonate trial in the treatment of various presentations of Schistosoma haematobium and Schistosoma mansoni infections in the Sudan, Ann. Trop. Med. Parasitol. 12:145–150.
Pellegrino, J., and Katz, N., 1968, Experimental chemotherapy of schistosomiasis mansoni, Adv. Parasitol. 6:233–290.
Pellegrino, J., and Katz, N., 1969, Experimental chemotherapy of schistosomiasis, part 4: oogram studies with nicarbazin, ang suppressive agent, Rev. Inst. Med. Trop. Sao Paulo 11:215–221.
Pellegrino, J., Lima-Costa, F. F., Carlos, M. A., and Mello, R. T., 1977, Experimental chemotherapy of schistosomiasis mansoni XIII, Z. Parasitenk. 52:151–168.
Pieron, R., Mafart, Y., Lesobre, B., Grivaux, M., and Lancastre, F., 1984, L’oltipraz en traitement bref de la schistosomose à S. haematobium. Trois prises en un jour ou une seule prise, Therapie 39:167–176.
Pitchford, R. J., and Lewis, A. M., 1978, Oxamniquine in the treatment of various schistosome infections in South Africa, South Afr. Med. J. 53:677–680.
Plestina, R., Davis, A., and Bailey, D. R., 1972, Effect of metrifonate on blood cholinesterases in children during the treatment of schistosomiasis, Bull. WHO 46:747–759
Pugh, R. N., and Teesdale, C. H., 1984, Long-term efficacy of single-dose oral treatment in schistosomiasis haematobium, Trans. R. Soc. Trop. Med. Hyg. 78:55–59.
Radomyos, P., Bunnag, D., and Harinasuta, T., 1982, Echinostoma ilocanum infection in man in Thailand, Southeast Asian J. Trop. Med. Publ. Health 13:265–269.
Rim, H. J., 1973, Chemotherapy of trematode infection excluding schistosomiasis, in: Proceedings of the Tenth SEAMEO-TROPMED Seminar: Symposium on Chemotherapy in Tropical Medicine of Southeast Asia and the Far East, October 26–30, 1972, Bangkok.
Rim, H. J., and Chang, Y. S., 1980, Chemotherapeutic effect of niclofolan and praziquantel in the treatment of paragonimiasis, Korea Univ. Med. J. 17:113–126.
Rim, H. J., Lyu, K. S., Lee, J. S., and Koo, K. H., 1981, Clinical evaluation of therapeutic effect of praziquantel (Embay 8440) against Clonorchis sinensis infection, Ann. Trop. Med. Parasitol. 15:27.
Rim, H. J., 1984, Paragonimiasis: Experimental and clinical experience with praziquantel in Korea, Arzneimittelforsch. 34(11): 1197–1203.
Ruenwongsa, P., and Thamavit, W., 1983, Increased efficacy of liposomes-Encapsulated praziquantel in treatment of opisthorchiasis in hamsters, Southeast Asian J. Trop. Med. Publ. Health 14:501–504.
Saif, M., Koura, M., and Abdel-Fattah, F., 1973, The oral treatment of 5. haematobium infection with metrifonate, J. Egypt. Med. Assoc. 56:527–531.
Santos, A. T., Blas, B. L., Nosenas, J. S., Portillo, G. P., Ortega, D. M., Hayashi, M., and Boehme, K., 1979, Preliminary clinical trials with praziquantel in Schistosoma japonicum infections in the Philippines, Bull. WHO 57:593–900.
Santos, A. T., Blas, B. L., Portillo, G. P., Nosenas, J. S., Poliquit, O., and Papasin, M., 1984, Phase III clinical trials with praziquantel in S. japonicum infections in the Philippines, Arzneimittelforsch. 34(II):1221–1223.
Sleigh, A. C., Mott, K. E., and Franca Silva, J. T., 1981, A three–year follow-up of chemotherapy with oxamniquine in a Brazilian community with endemic schistosomiasis, Trans. R. Soc. Trop. Hyg. 75:234–238.
Soh, C. T., 1984, Clonorchis sinensis: Experimental and clinical studies with praziquantel in Korea, Arzneimittelforsch. 34(II): 1156–1159.
Sornmani, S., Schelp, F. P., Vivatanasesth, P., Patihatakorn, W., Impand, P., Sitabutra, P., Worasan, P., and Preuksaraj, S., 1984, A pilot project for controlling O. viverrini infection in Nong Wai, Northeast Thailand, by applying praziquantel and other measures, Arzneimittelforsch. 34(11): 1231–1234.
Spitalny, K. C., Senft, A. W., Meglio, F. D., Morgan, J., and Peter, G., 1982, Treatment of pulmonary paragonimiasis with a new broad-spectrum anthelmintic, praziquantel, J. Pediatr. 101:144–146.
Standen, O. D., 1963, Chemotherapy of helminthic infections, in: Experimental Chemotherapy (R. J. Schnitzer and F. Hawking, eds.), Vol. 1, pp. 701–892, Academic Press, New York and London.
Supanvanich, S., Supavonich, K., and Pawabut, P., 1981, Field trial of praziquantel in human opisthorchiasis in Thailand, Southeast Asian J. Trop. Med. Publ. Health 12:598–602.
Vanijanonta, S., Bunnag, D., and Harinasuta, T., 1984, Paragonimus heterotremus and other Paragonimus spp. in Thailand: Pathogenesis, clinic and treatment, Arzneimittelforsch. 34(11): 1186–1188.
Warren, K. S., 1970, Suppression of hepatosplenic schistosomiasis mansoni in mice by nicarbazin, a drug that inhibits egg production by schistosomes, J. Infect. Dis. 121:514–521.
Warren, K. S., and Mahmoud, A. A. F., 1976, Targeted mass treatment. A new approach to the control of schistosomiasis, Trans. Assoc. Am. Physicians 89:195–204.
Webbe, G., and James, C., 1977, A comparison of the susceptibility of praziquantel of Schistosomahaematobium, S. japonicum, S. mansoni, S. intercalatum and S. mattheei in hamsters, Z. Parasitenk. 52:169–177.
Webbe, G., and Jordan, P., 1982, Control, in: Schistosomiasis (P. Jordan and G. Webbe, eds.), pp. 293–349, Heinemann Medical Books, London.
Wegner, D. H. G., 1984, The profile of the trematodicidal compound praziquantel, Arzneimittelforsch. 34(11): 1132–1136.
Wykoff, D. E., 1958, Studies on Clonorchis sinensis. III, J. Parasitol. 44:461–466.
Yokogawa, M., 1984, Experimental chemotherapy of paragonimiasis, Arzneimittelforsch. 34(11): 1193–1196.
Yoshida, Y., Miyaké, T., Nakaniski, Y., Nishido, K., Yamanashi, Y., Ishikawa, T., Fujisoka, K., Tanaka, A., and Embara, S., 1962, Cases of human infection with Fasciola sp. and treatment with Bithionol, Jpn.J. Parasitol. 11:41–43.
Zhou, G. X., 1983, Clinical observation on schistosomiasis japonica treated with amoscanate and phenithionate in a hyperendemic area, Chung Hua Nei Ko Tsa Chih 22:634–645
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Campbell, W.C., Garcia, E.G. (1986). Trematode Infections of Man. In: Campbell, W.C., Rew, R.S. (eds) Chemotherapy of Parasitic Diseases. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1233-8_19
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