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Chemotherapy of Parasitic Diseases pp 339–362Cite as

Drug Resistance in Nematodes

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Abstract

Drug resistance in nematodes is almost solely confined to the strongylid parasites of the alimentary tract of grazing livestock. Few reports have been made on the resistance in plant-parasitic nematodes (Foot, 1980), and none for nematode parasites of man. Unlike drug resistance in bacteria, protozoa, and arthropods, resistance in nematodes to anthelmintics has been slow to develop and is patchy in worldwide distribution. However, this does not constitute grounds for complacency. It is not necessary for anthelmintic resistance to have reached a high level to be a serious problem. Evidence that it has increased from negligibly small levels and that it exists in two of the three widely used broad-spectrum drug groups means it would be foolhardy to assume that its prevalence and thus importance will not escalate, unless effective countermeasures are undertaken.

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References

  • Anderson, N., and Laby, R.H., 1979, Activity against Ostertagia ostertagi of low doses of oxfendazole continuously released from intraruminal capsules in cattle, Aust. Vet. J. 55:244–246.

    PubMed  CAS  Google Scholar 

  • Anderson, N., Laby, R.H., Prichard, R.K., and Hennessy, D., 1980, Controlled release of anthelmintic drugs: A new concept for prevention of helminthosis in sheep, Res. Vet. Sci. 29:333–341.

    PubMed  CAS  Google Scholar 

  • Anonymous, 1983, Worms in Sheep and Goats on the N.S.W. North Coast, No. 3: Results of Drench Resistance Survey, Information from Department of Agriculture, New South Wales.

    Google Scholar 

  • Beadles, M.L., Miller, J.A., Chamberlain, W.F., Eschle, J.L., and Harris, R.L., 1975, The hornfly: Methoprene in drinking water of cattle for control, J. Econ. Entomol. 68:781–785.

    PubMed  CAS  Google Scholar 

  • Bennet, E. M., 1981, Biochemical studies on the nature of benzimidazole resistance in Hamonchus contortus (Rudolphi, 1803), Ph.D. thesis, Australian National University, Canberra.

    Google Scholar 

  • Bennet, E.M., Behm, C., Bryant, C., and Chevis, R.A.F., 1980, Synergistic action of mebendazole and levamisole in the treatment of benzimidazole-resistant Haemonchus contortus in sheep, Vet. Parasitol. 7:207–214.

    Article  CAS  Google Scholar 

  • Berger, J., 1975, The resistance of a field strain of Haemonchus contortus to five benzimidazole anthelmintics in current use, J. South Afr. Vet. Assoc. 46:369–372.

    CAS  Google Scholar 

  • Bernier-Valentin, F., and Rousset, B., 1982, Interaction of tubulin with rat liver mitochondria, J. Biol. Chem. 257:7092–7099.

    PubMed  CAS  Google Scholar 

  • Bernier-Valentin, F., Aunis, D., and Rousset, B., 1983, Evidence for tubulin-binding sites on cellular membranes: plasma membranes, mitochondrial membranes and secretary granule membranes, J. Cell Biol. 97:209–216.

    Article  PubMed  CAS  Google Scholar 

  • Blanch, L., 1984, Resistance to wormers in sheep. A sheep breeder’s experience, Aust. Rural Chem. Mag. 1:28–31.

    Google Scholar 

  • Boersema, J.H., Leweng-van der Wiel, P.J., and Borgsteede, F.H.M., 1982, Benzimidazole resistance in a field strain of Haemonchus contortus in The Netherlands, Vet. Rec. 110:203–24.

    Article  PubMed  CAS  Google Scholar 

  • Boisvenue, R.J., Emmick, T.L., and Galloway, R.B., 1977, Haemonchus contortus: Effects of compounds with juvenile hormone activity on the in vitro development of infective larvae, Exp. Parasitol. 42:67–72.

    Article  PubMed  CAS  Google Scholar 

  • Britt, D.P., 1982, Benzimidazole-resistant nematodes in Britain, Vet. Rec. 110:343–344.

    Article  PubMed  CAS  Google Scholar 

  • Brown, A.W.A., and Pal, R., 1971, Insecticide Resistance in Arthropods, 2nd ed., World Health Organization, Geneva, Switzerland.

    Google Scholar 

  • Campbell, W.C., Fisher, M.H., Stapley, E.O., Albers-Schönberg, G., and Jacob, T.A., 1983, Ivermectin: A potent new antiparasitic agent, Science 221:823–827.

    Article  PubMed  CAS  Google Scholar 

  • Cawthorne, R.J.G., and Cheong, F.H., 1984, Prevalence of anthelmintic resistant nematodes in south-east England, Vet. Rec. 114:562–564.

    Article  PubMed  CAS  Google Scholar 

  • Coles, G.C., 1977, The biochemical mode of action of some modern anthelmintics, Pesticide Sci. 8:536–543.

    Article  CAS  Google Scholar 

  • Coles, G.C., and Simpkin, K.G., 1977, Resistance of nematode eggs to the ovicidal activity of benzimidazoles, Res. Vet. Sci. 22:386–387.

    PubMed  CAS  Google Scholar 

  • Comins, H.N., 1977, The management of pesticide resistance, J. Theoret. Biol. 65:399–420.

    Article  CAS  Google Scholar 

  • Dineen, J.K., and Outteridge, P.M., 1984, Immunogenetic Approaches to the Control of Endoparasites with Particular Reference to Parasites of Sheep, C.S.I.R.O. Division of Animal Health, Melbourne, Australia.

    Google Scholar 

  • Dineen, J.K., and Wagland, B.M., 1982, Immunoregulation of parasites in natural host — parasite systems — With special reference to the gastrointestinal nematodes of sheep, in: Biology and Control of Endoparasites (L. E. A. Symons, A. D. Donald, and J. K. Dineen, eds.), pp. 297–329, Academic Press, Sydney, Australia.

    Google Scholar 

  • Dobson, R. J., Donald, A. D., Waller, P. J., and Snewdon, K. L., 1985, An egg-hatch assay for resistance to levamisole in trichostrongyloid nematode parasites, Vet. Parasitol. (in press).

    Google Scholar 

  • Donald, A.D., 1983a, The development of anthelmintic resistance in nematodes of grazing animals, in: Facts and Reflections. IV. Resistance of Parasites to Anthelmintics (F. H. M. Borgsteede, Sv. Aa. Henriksen, and H. J. Over, eds.), pp. 15–28, Central Veterinary Institute, Lelystad, The Netherlands.

    Google Scholar 

  • Donald, A.D., 1983b, Anthelmintic resistance in relation to helminth control and grazing systems, in: Facts and Reflections. IV. Resistance of Parasites to Anthelmintics (F. H. M. Borgsteede, Sv. Aa. Henriksen, and H. J. Over, eds.), pp. 187–198, Central Veterinary Institute, Lelystad, The Netherlands.

    Google Scholar 

  • Donald, A.D., and Waller, P.J., 1982, Problems and prospects in the control of helminthiasis in sheep, in: Biology and Control of Endoparasites (L. E. A. Symons, A. D. Donald, and J. K. Dineen, eds.), pp. 157–186, Academic Press, Sydney, Australia.

    Google Scholar 

  • Donald, A.D., Waller, P.J., Dobson, R.J., and Axelsen, A., 1980, The effect of selection with levamisole on benzimidazole resistance in Ostertagia spp. of sheep, Int. J. Parasitol. 10:381–389.

    Article  PubMed  CAS  Google Scholar 

  • Drudge, J.H., and Lyons, E.T., 1965, Newer developments in helminth control and Strongylus vulgaris research, Proc. Am. Assoc. Equine Pract. 115:381–389.

    Google Scholar 

  • Drudge, J.H., Lyons, E.T., and Tolliver, S.C., 1979, Benzimidazole resistance of equine strongyles — Critical tests of six compounds against Population B, Am.J. Vet. Res. 40:590–594.

    PubMed  CAS  Google Scholar 

  • Foot, M.A., 1980, Nematicide resistance in plant-parasitic nematodes, N. Z.J. Zool. 7:599.

    Google Scholar 

  • Georghiou, G.P., and Taylor, C.E., 1977, Genetic and biological influences in the evolution of insecticide resistance, J. Econ. Entomol. 70:319–323.

    PubMed  CAS  Google Scholar 

  • Green, P.E., Forsyth, B.A., Rowan, K.J., and Payne, G., 1981, The isolation of a field strain of Haemonchus contortus in Queensland showing multiple anthelmintic resistance, Aust. Vet. J. 57:79–84.

    Article  PubMed  CAS  Google Scholar 

  • Green, P. E., Murphy, M. L., and O’Sullivan, B. M., 1982, Anthelmintic resistance studies in goats in south-east Queensland, Aust. Adv. Vet. Sci. 181-183.

    Google Scholar 

  • Gunawan, M., Sangster, N.C., Kelly, J.D., Griffin, D., and Whitlock, H.V., 1979, The efficacy of fenbendazole and albendazole against immature and adult stages of benzimidazole-resistant sheep trichostrongylids, Res. Vet. Sci. 27:111–115.

    PubMed  CAS  Google Scholar 

  • Hall, C.A., Kelly, J.D., Campbell, N.J., Whitlock, H.V., and Martin, I.C.A., 1978, The dose response of several benzimidazole anthelmintics against resistant strains of Haemonchus contortus and Trichostrongylus colubriformis selected with thiabendazole, Res. Vet. Sci. 25:364–367.

    PubMed  CAS  Google Scholar 

  • Hall, C.A., Kelly, J.D., Whitlock, H.V., Martin, I.C.A., McDonell, P.A., and Gunawan, M., 1981a, Five generations of selection with benzimidazole and non-benzimidazole anthelmintics against benzimidazole resistant strains of Haemonchus contortus and Ostertagia spp. in sheep, Res. Vet. Sci. 30:138–142.

    PubMed  CAS  Google Scholar 

  • Hall, C.A., Ritchie, L., and McDonell, 1981b, Investigations for anthelmintic resistance in gastrointestinal nematodes from goats, Res. Vet. Sci. 31:116–119.

    PubMed  CAS  Google Scholar 

  • Hall, C.A., Kelly, J.D., Martin, I.C.A., Whitlock, H.V., McDonnell, P.A., and Gunewan, M., 1981c, Changes in response to a benzimidazole resistant strain of Haemonchus contortus sheep after passing through calves, Res. Vet. Sci. 30:143–146.

    PubMed  CAS  Google Scholar 

  • Harris, R.L., Frazer, E.D., and Younger, R.L., 1973, Horn flies, stable flies and house flies: development in feces of bovines treated orally with juvenile hormone analogues, J. Econ. Entomol. 66:1099–1102.

    PubMed  CAS  Google Scholar 

  • Harris, R.L., Chamberlain, W.F., and Frazer, E.P., 1974, Horn flies and stable flies: Free-choice feeding of methoprene mineral blocks to cattle for control, J. Econ. Entomol. 67:384–386.

    PubMed  CAS  Google Scholar 

  • Hennessy, D.R., Lacey, E., and Prichard, R.K., 1983, Pharmacokinetic behaviour and anthelmintic efficacy of 1-n-butyl carbamoyl oxfendazole given by intramuscular injection, Vet. Res. Commun. 6:177–187.

    Article  PubMed  CAS  Google Scholar 

  • Herd, R.P., Miller, T.B., and Gabel, A.A., 1981, A field evaluation of probenzimidazole, benzimidazole and non-benzimidazole anthelmintics in horses, J. Am. Vet. Med. Assoc. 179:686–691.

    PubMed  CAS  Google Scholar 

  • Herlich, H., Rew, R.S., and Colglazier, M.L., 1981, Inheritance of cambendazole resistance in Haemonchus contortus, Am. J. Vet. Res. 42:1342–1344.

    PubMed  CAS  Google Scholar 

  • Hogarth-Scott, R.S., Kelly, J.D., Whitlock, H.V., Ng, B.K.Y., Thompson, H.G., James, R.E., and Mears, F.A., 1976, The anthelmintic efficacy of fenbendazole against thiabendazole-resistant strains of Haemonchus contortus and Trichostrongylus colubriformis in sheep, Res. Vet. Sci. 21:232–237.

    PubMed  CAS  Google Scholar 

  • Hughes, P.L., and Seifert, D.A., 1983, Field comment on anthelmintic resistance of sheep nematodes, N. Z. Vet. J. 31:183–184.

    Article  CAS  Google Scholar 

  • Johnstone, I.L., Darvill, F.M., Bowen, F.L., Butler, R.W., Smart, K.E., and Pearson, I.G., 1979, The effect of four schemes of parasite control on production in Merino wether weaners in two environments, Aust. J. Exp. Agr. Husb. 19:303–311.

    Article  Google Scholar 

  • Jones, R.M., 1981, A field study of the morantel sustained release bolus in the seasonal control of parasitic gastroenteritis in grazing calves, Vet. Parasitol. 8:237–251.

    Article  Google Scholar 

  • Jordi, R., 1980, Untersuchungen zur Anthelminthika Resistanz von Trichostrongyliden des Schafes, Schweiz. Arch. Tierheilkd. 122:679–694.

    PubMed  CAS  Google Scholar 

  • Kelly, J.D., and Hall, C.A., 1979, Anthelmintic resistance in nematodes. 1. History, present status in Australia, genetic background and methods for field diagnosis, N. S. W. Vet. Proc. 15:19–31.

    Google Scholar 

  • Kelly J.D., Hall, C.A., Whitlock, H.V., Thompson, H.G., Campbell, N.J., and Martin, I.C.A., 1977, The effect of route of administration on the anthelmintic efficacy of benzimidazole anthelmintics in sheep infected with strains of Haemonchus contortus and Trichostrongylus colubriformis resistant or susceptible to thiabendazole, Res. Vet. Sci. 22:161–168.

    PubMed  CAS  Google Scholar 

  • Kelly, J.D., Whitlock, H.V., Thompson, N.G., Hall, C.A., Martin, I.C.A., and Le Jambre, L.F., 1978, Physiological characteristics of free-living and parasitic stages of strains of Haemonchus contortus, susceptible or resistant to benzimidazole anthelmintics, Res. Vet. Sci. 25:376–385.

    PubMed  CAS  Google Scholar 

  • Kelly, J.D., Whitlock, H.V., Gunawan, M., Griffin, D., Porter, C.J., and Martin, I.C.A., 1981a, Anthelmintic efficacy of low-dose phenothiazine against strains of sheep nematodes susceptible or resistant to thiabendazole, levamisole and morantel tartrate: Effect on patent infections, Res. Vet. Sci. 30:161–169.

    PubMed  CAS  Google Scholar 

  • Kelly, J.D., Webster, J.H., Griffin, D.L., Whitlock, H.V., Martin, I.C.A., and Gunawan, M., 1981b, Resistance to benzimidazole anthelmintics in equine strongyles. 1. Frequency, geographical distribution and relationship between occurrence, animal husbandry procedures and anthelmintic usage, Aust. Vet.J. 57:163–171.

    Article  PubMed  CAS  Google Scholar 

  • Kemp, G.K., and Smith, C.F., 1982, Anthelmintic resistance survey in New Zealand, N. Z. Vet. J. 30:141–144.

    Article  PubMed  CAS  Google Scholar 

  • Kettle, P.R., Vlassoff, A., Lukers, J.M., Ayling, J.M., and McMurtry, L.W., 1981, A survey of nematode control measures used by sheep farmers and of anthelmintic resistance on their farms. Part 1: North Island and the Nelson region of the South Island, N. Z. Vet. J. 29:81–83.

    Article  PubMed  CAS  Google Scholar 

  • Kettle, P.R., Vlassoff, A., Ayling, J.M., McMurtry, L.W., Smith, S.W., and Watson, A.J., 1982, A survey of nematode control measures used by sheep farmers and of anthelmintic resistance on their farms. Part 2: South Island excluding the Nelson region, N. Z. Vet. J. 30:79–81.

    Article  PubMed  CAS  Google Scholar 

  • Kettle, P.R., Vlassoff, A., Reid, T.C., and Horton, C.T., 1983, A survey of nematode control measures used by milking goat farmers and of anthelmintic resistance on their farms, N. Z. Vet. J. 31:139–143.

    Article  PubMed  CAS  Google Scholar 

  • Lejambre, L.F., 1976, Egg hatch as an in vitro assay of thiabendazole resistance in nematodes, Vet. Parasitol. 2:385–391.

    Article  CAS  Google Scholar 

  • Le Jambre, L.F., 1978, Anthelmintic resistance in gastrointestinal nematodes of sheep, in: The Epidemiology and Control of Gastrointestinal Parasites of Sheep in Australia (A. D. Donald, W. H. Southcott, and J. K. Dineen, eds.), pp. 109–120, C.S.I.R.O. Division of Animal Health, Melbourne, Australia.

    Google Scholar 

  • Le Jambre, L.F., 1982, Genetics and the control of trichostrongylid parasites of ruminants, in: Biology and Control of Endoparasites (L. E. A. Symons, A. D. Donald, and J. K. Dineen, eds.), pp. 53–80, Academic Press, Sydney, Australia.

    Google Scholar 

  • Le Jambre, L.F., Southcott, W.H., and Dash, K.M., 1976, Resistance of selected lines of Haemonchus contortus to thiabendazole, morantel tartrate and levamisole, Int.J. Parasitol. 6:217–222.

    Article  PubMed  Google Scholar 

  • Le Jambre, L.F., Southcott, W.H., and Dash, K.M., 1977, Resistance of selected lines of Ostertagia circumcincta to thiabendazole, morantel tartrate and levamisole, Int. J. Parasitol. 7:473–479.

    Article  PubMed  Google Scholar 

  • Le Jambre, L.F., Southcott, W.H., and Dash, K.M., 1978a, Development of simultaneous resistance in Ostertagia circumcincta to thiabendazole, morantel tartrate and levamisole, Int. J. Parasitol. 8:473–479.

    Google Scholar 

  • Le Jambre, L.F., Southcott, W.H., and Dash, K.M., 1978b, Effectiveness of broad spectrum anthelmintics against selected strains of Trichostrongylus colubriformis, Aust. Vet. J. 54:570–574.

    Article  PubMed  Google Scholar 

  • Le Jambre, L.F., Royal, W.M., and Martin, P.J., 1979, The inheritance of thiabendazole resistance in Haemonchus contortus, Parasitology 78:107–119.

    Article  PubMed  Google Scholar 

  • Lewis, J.A., Wu, C.H., Levine, J.H., and Berg, H., 1980, Levamisole-resistant mutants of the nematode Caenorhabditis elegans appear to lack pharmacological acetylcholine receptors, Neuroscience 5:967–989.

    Article  PubMed  CAS  Google Scholar 

  • Lyons, E.T., Tolliver, S.C., Drudge, J.H., Hemken, R.W., and Button, F.S., 1981, Efficacy of levamisole against abomasal nematodes and lungworms in dairy calves: Preliminary tests indicating reduced activity for Ostertagia ostertagi, Am. J. Vet. Res. 42:1228–1230.

    Google Scholar 

  • Malkin, M.F., and Camacho, R.M., 1972, The effect of thiabendazole on fumarate reductase from thiabendazole-sensitive and resistant Haemonchus contortus, J. Parasitol. 58:845–846.

    Article  PubMed  CAS  Google Scholar 

  • Martin, P.J., and Le Jambre, L.F., 1979, Larval paralysis as an in vitro assay of levamisole and morantel tartrate resistance in Ostertagia, Vet. Sci. Commun. 3:159–164.

    Article  Google Scholar 

  • Martin, P.J., Le Jambre, L.F., and Claxton, J.H., 1981, The impact of refugia on the development of thiabendazole resistance in Haemonchus contortus, Int. J. Parasitol. 11:35–41.

    Article  PubMed  CAS  Google Scholar 

  • Martin, P.J., Anderson, N., Jarrett, R.G., Brown, T.H., and Ford, G.E., 1982, Effects of a preventive and a suppressive control scheme on the development of thiabendazole resistance in Ostertagia spp., Aust. Vet. J. 58:185–190.

    Article  PubMed  CAS  Google Scholar 

  • McKenzie, J.A., Dearn, J.M., and Whitten, M.J., 1980, Genetic basis of resistance to diazinon in Victorian populations of the Australian sheep blowfly, Lucilia cuprina, Aust. J. Biol. Sci. 33:85–95.

    PubMed  CAS  Google Scholar 

  • Michel, J.F., 1963, The phenomena of host resistance and the course of infection of Ostertagia ostertagi in calves, Parasitology 53:63–84.

    Article  Google Scholar 

  • Michel, J.F., 1969, Some observations on the worm burdens of calves infected daily with Ostertagia ostertagi, Parasitology 59:575–595.

    Article  PubMed  CAS  Google Scholar 

  • Michel, J.F., Cawthorne, R.J.G., Anderson, R.M., Armour, J., Clarkson, M.J., and Thomas, R.J., 1983, Resistance to anthelmintics in Britain: husbandry practices and selective pressure, in: Facts and Reflections. IV. Resistance of Parasites to Anthelmintics (F. H. M. Borgsteede, Sv. Aa. Henriksen, and H. J. Over, eds.), pp. 41–59, Central Veterinary Institute, Lelystad, The Netherlands.

    Google Scholar 

  • Middleberg, A., and McKenna, P.B., 1983, Oxfendazole resistance in Nematodirus spathiger, N. Z. Vet. J. 31:65–66.

    Article  Google Scholar 

  • Miller, J.A., Chamberlain, W.F., Beadles, M.L., Pickens, M.O., and Gingrich, A.R., 1976, Methoprene for control of horn flies: Application to drinking water of cattle via a tablet formulation, J. Econ. Entomol. 69:330–332.

    PubMed  CAS  Google Scholar 

  • Miller, J.A., Beadles, M.L., Palmer, J.S., and Pickens, M.O., 1977, Methoprene for control of the horn fly: A sustained-release bolus formulation for cattle, J. Econ. Entomol. 70:589–591.

    PubMed  CAS  Google Scholar 

  • Powers, K.G., Wood, I.B., Eckert, J., Gibson, T., and Smith, H.J., 1982, World Association for the Advancement of Veterinary Parasitology. Guidelines for evaluating the efficacy of anthelmintics in ruminants (Bovine and ovine), Vet. Parasitol. 10:265–284.

    Article  PubMed  CAS  Google Scholar 

  • Prichard, R.K., 1973, The fumarate reductase reaction of Haemonchus contortus and the mode of action of some anthelmintics, Int. J. Parasitol. 3:409–417.

    Article  PubMed  CAS  Google Scholar 

  • Prichard, R.K., 1978, Sheep anthelmintics, in: The Epidemiology and Control of Gastrointestinal Parasites of Sheep in Australia (A. D. Donald, W. H. Southcott, and J. K. Dineen, eds.), pp. 75–107, C.S.I.R.O. Division of Animal Health, Melbourne, Australia.

    Google Scholar 

  • Prichard, R.K., Kelly, J.D., and Thompson, H.G., 1978, The effects of benzimidazole resistance and route of administration on the uptake of fenbendazole and thiabendazole by Haemonchus contortus and Trichostrongylus colubriformis in sheep, Vet. Parasitol. 4:243–255.

    Article  CAS  Google Scholar 

  • Prichard, R.K., Hall, C.A., Kelly, J.D., Martin, I.C.A., and Donald, A.D., 1980, The problem of anthelmintic resistance in nematodes, Aust. Vet. J. 56:239–251.

    Article  PubMed  CAS  Google Scholar 

  • Rew, R.S., Smith, C., and Colglazier, M.L., 1982, Glucose metabolism of Haemonchus contortus adults: Effects of thiabendazole on susceptible versus resistant strain, J. Parasitol. 68:845–850.

    Article  PubMed  CAS  Google Scholar 

  • Rogers, W.P., 1973, Juvenile and moulting hormones from nematodes, Parasitology 67:105–113.

    Article  Google Scholar 

  • Rogers, W.P., 1978, The inhibitory action of insect juvenile hormone on the hatching of nematode eggs, Comp. Biochem. Physiol. 6lA:187–190.

    Article  Google Scholar 

  • Romanowski, R.D., Rhoads, M.L., Colglazier, M.L., and Kates, K.C., 1975, Effect of cambendazole, thiabendazole and levamisole on fumarate reductase in cambendazole-resistant and sensitive strains of Haemonchus contortus, J. Parasitol. 61:777–778.

    Article  PubMed  CAS  Google Scholar 

  • Round, M.C., Simpson, D.J., Haselden, C.S., Glendenning, E.S.A., and Barkerville, R.E., 1974, Horse strongyles’ tolerance to anthelmintics, Vet. Rec. 95:517–518.

    Article  PubMed  CAS  Google Scholar 

  • Sangster, N.C., and Prichard, R.K., 1984, Uptake of thiabendazole and its effects on glucose uptake and carbohydrate levels in thiabendazole-resistant and susceptible Trichostrongylus colubriformis, Int. J. Parasitol. 14:121–126.

    Article  PubMed  CAS  Google Scholar 

  • Sangster, N.C., Whitlock, H.V., Russ, I.G., Gunawan, M., Griffin, D.L., and Kelly, J.D., 1979, Trichostrongylus colubriformis and Ostertagia circumcincta resistant to levamisole, morantel tartrate and thiabendazole: Occurrence of field strains, Res. Vet. Sci. 27:106–110.

    PubMed  CAS  Google Scholar 

  • Sangster, N.C., Kelly, J.D., Whitlock, H.V., Gunawan, M., and Porter, C.J., 1980, Trichostrongylus colubriformis and Ostertagia sp. resistant to levamisole, morantel tartrate and thiabendazole: Infectivity, pathogenicity and drug efficacy in two breeds of sheep, Res. Vet. Sci. 29:26–30.

    PubMed  CAS  Google Scholar 

  • Sangster, N. C., Pritchard, R. K., and Lacey, E., 1985, Tubulin and benzimidazole-resistance in Trichostrongylus colubriformis (Nematoda), J. Parasitol. (in press).

    Google Scholar 

  • Santiago, M.A.M., da Costa, U., and Benevenga, S.F., 1978, Anthelmintic activity of dl-Tetramisole and thiabendazole on a levamisole resistant strain of Trichostrongylus colubriformis, Rev. Centro Ciencias Rurais 8:257–261.

    CAS  Google Scholar 

  • dos Santos, V. T., and Franco, E. B. O., 1967, A parecimento de Haemonchus resistene AO radical benzimidazole EM Uruguaiana, Proceedings of the First Latin-American Congress of Parasitology, Santiago, Chile, p. 105.

    Google Scholar 

  • Slocombe, J.O.D., and Cote, J.F., 1977, Small strongyles of horses with cross-resistance to benzimidazole anthelmintics and susceptibility to unrelated compounds, Can. Vet. J. 18:212–217.

    PubMed  CAS  Google Scholar 

  • Suthurst, R.W., and Comins, H.N., 1979, The management of acaricide resistance in the cattle tick, Boophilus microplus (Canestrini) (Acari:Ixodidae), in Australia, Bull. Entomol. Res. 69:519–537.

    Article  Google Scholar 

  • Turton, J.A., and Clark, C.J., 1974, The effect of natural worm loss on the estimate of anthelmintic activity in an anthelmintic test with Haemonchus contortus, Parasitology 69:191–196.

    Article  PubMed  CAS  Google Scholar 

  • van Wyck, J.A., and Gerber, H.M., 1980, A field strain of Haemonchus contortus showing slight resistance to rafoxanide, Onderstepoort J. Vet. Res. 47:137–142.

    Google Scholar 

  • Waller, P.J., Dobson, R.J., and Donald, A.D., 1983, Further studies of the effect of selection with levamisole on a benzimidazole resistant population of Ostertagia spp. of sheep, Int. J. Parasitol. 13:463–468.

    Article  PubMed  CAS  Google Scholar 

  • Waller, P. J., Dobson, R. J., Donald, A. D., Griffiths, D. A., and Smith, E. F., 1985, Selection studies on anthelmintic resistant and susceptable populations of Trichostrongylus colubriformis of sheep, International Journal of Parasitology (in press).

    Google Scholar 

  • Webb, R.F., McCully, C.H., Clarke, F.L., Greentree, P., and Honey, P., 1979, The incidence of thiabendazole resistance in field populations of Haemonchus contortus on the Northern Tablelands of New South Wales, Aust. Vet. J. 55:422–426.

    Article  PubMed  CAS  Google Scholar 

  • Weston, K.M., O’Brien, R.W., and Prichard, R.K., 1984, Respiratory metabolism and thiabendazole susceptibility in developing eggs of Haemonchus contortus, Int. J. Parasitol. 14:159–164.

    Article  PubMed  CAS  Google Scholar 

  • Whitlock, H.V., Sangster, N.C., Gunawan, M., Porter, C.J., and Kelly, J.D., 1980a, Trichostrongylus colubriformis and Ostertagia sp. resistant to levamisole, morantel tartrate and thiabendazole: Isolation into pure strain anthelmintic titration, Res. Vet. Sci. 29:31–35.

    PubMed  CAS  Google Scholar 

  • Whitlock, H.V., Kelly, J.D., Porter, C.J., Griffin, D.L., and Martin, I.C.A., 1980b, In vitro field screening for anthelmintic resistance in strongyles of sheep and horses, Vet. Parasitol. 7:215–232.

    Article  Google Scholar 

  • Whitten, M.J., Dearn, J.M., and McKenzie, J.A., 1980, Field studies on insecticide resistance in the Australian sheep blowfly, Lucilia cuprina, Aust. J. Biol. Sci. 33:725–735.

    CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Animal Health, McMaster Laboratory, CSIRO, Glebe, New South Wales, 2037, Australia

    Peter J. Waller

  2. Institute of Parasitology, McGill University, Macdonald College, Ste. Anne-de-Bellevue, Quebec, H9X 1CO, Canada

    Roger K. Prichard

Authors
  1. Peter J. Waller
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  2. Roger K. Prichard
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Editor information

Editors and Affiliations

  1. Merck Institute for Therapeutic Research, Rahway, New Jersey, USA

    William C. Campbell

  2. Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey, USA

    Robert S. Rew

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© 1986 Plenum Press, New York

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Waller, P.J., Prichard, R.K. (1986). Drug Resistance in Nematodes. In: Campbell, W.C., Rew, R.S. (eds) Chemotherapy of Parasitic Diseases. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1233-8_17

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  • DOI: https://doi.org/10.1007/978-1-4684-1233-8_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1235-2

  • Online ISBN: 978-1-4684-1233-8

  • eBook Packages: Springer Book Archive

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