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Nematode Infections of Man: Extraintestinal Infections

  • Chapter
Chemotherapy of Parasitic Diseases

Abstract

Despite a plethora of anthelmintics active against the nematodes parasitizing the human gut, as illustrated in Chapter 12, far fewer drugs have been or can be used in the treatment of those nematodes that parasitize other organs. This chapter deals with the chemotherapy of diseases caused by such nematodes.

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References

  • Abdel-Hamfeed, A.A., 1984, Effect of thiabendazole on the migration of Toxocara cants larvae in the mouse, Parasitol. 70:226–231.

    Article  Google Scholar 

  • Abo-Shehada, M.N., and Herbert, I.V., 1984, Anthelmintic effect of levamisole, ivermectin, albendazole and fenbendazole on larval Toxocara canis infection in mice, Res. Vet. Sci. 36:87–91.

    PubMed  CAS  Google Scholar 

  • Ambu, S., Kwa, B.H., and Mak, J.W., 1982, Studies on the experimental chemotherapy of Angiostrongylus malaysiensis infection in rats with mebendazole and levamisole, Trans. R. Soc. Trop. Med. Hyg. 76:458–462.

    Article  PubMed  CAS  Google Scholar 

  • Anderson, J., and Fuglsang, H., 1976, Ocular onchocerciasis: “At risk” patients and their treatment, Tropenmed. Parasitol. 26:13.

    Google Scholar 

  • Anderson, J., and Fuglsang, H., 1978, Further studies on the treatment of ocular onchocerciasis with diethylcarbamazine and suramin, Br. J. Ophthalmol. 62:450–457.

    Article  PubMed  CAS  Google Scholar 

  • Ash, L.R., and Riley, J.M., 1970, Development of Brugia pahangi in the jird, Meriones unguiculatus, with notes on infections in other rodents, J. Parasitol. 56:962–968.

    Article  PubMed  CAS  Google Scholar 

  • Awadzi, K., and Gilles, H.M., 1980, The chemotherapy of onchocerciasis. III. Comparative study of diethylcarbamazine (DEC) and metrifonate, Ann. Trop. Med. Hyg. 74:199–210.

    CAS  Google Scholar 

  • Aziz, M.A., Diallo, S., Diop, I.M., Larivere, M., and Porta, M., 1982, Efficacy of ivermectin in human onchocerciasis, Lancet 2:171–173.

    Article  PubMed  CAS  Google Scholar 

  • Barrett, J., 1983, Biochemistry of filarial worms, Helm. Abst. A. 52:1–18.

    Google Scholar 

  • Battistini, F., 1969, Treatment of creeping eruption with topical thiabendazole, Tex. Rep. Biol. Med. 27:645.

    PubMed  Google Scholar 

  • Bekhti, A., 1984, Mebendazole in toxocariasis, (letter), Ann. Int. Med. 100:463.

    PubMed  CAS  Google Scholar 

  • Bianco, A.E., and Denham, D.A., 1984, The action of diethylcarbamazine on the skin-dwelling microfilariae of Monanema globulosa (Nematoda: Filarioidae) in rodents, Tropenmed. Parasitol. 35:55–57.

    Google Scholar 

  • Bonnin, H., and Moretti, G.F., 1950, Preuves cliniques et biopsiques de l’action léthale d’un dérivé de la piperazine sur la filaire Loa loa adulte, Bull. Soc. Pathol. Exot. 43:279–282.

    Google Scholar 

  • Burren, C.H., 1968, Experimental toxocariasis. II. Toxocara canis in the mouse as a system for testing compounds of potential anthelmintic activity, Z. Parasitaikd. 30:162–170.

    Article  CAS  Google Scholar 

  • Campbell, W.C., 1982, Efficacy of the avermectins against filarial parasites: A short review, Vet. Res. Commun. 5:251–262.

    Article  PubMed  CAS  Google Scholar 

  • Campbell, W.C., and Denham, D.A., 1983, Chemotherapy, in: Trichinella and Trichinosis (W. C. Campbell, ed.), pp. 335–366, Plenum Press, New York.

    Chapter  Google Scholar 

  • Ch’en, T.T., 1964, Demonstration of macrofilaricidal action of hetrazan, antimony and arsenic preparations in man, Chinese Med. J. 83:625–640.

    CAS  Google Scholar 

  • Copeman, D.B., 1979, An evaluation of the bovine — Onchocerca gibsoni, Onchocerca gutturosa model as a tertiary screen for drugs against Onchocerca volvulus in man, Tropenmed. Parasitol. 30:469–474.

    Google Scholar 

  • Coulaud, J.P., Binet, D., Voyer, C., Samson, C., Moreau, G., Rossignol, J.F., 1982, Traitement du syndrome de larva migrans cutane “Larbish” par l’albendazole, Bull. Soc. Pathol. Exot. 75:534–537.

    CAS  Google Scholar 

  • Coulaud, J.P., Larivière, M., Gervais, M.C., Gaxotte, P., Aziz, A., Deluol, A.M., and Cenac, J., 1983, Traitement de l’onchocercose humaine par l’ivermectine, Bull. Soc. Pathol. Exot. 76:681–688.

    CAS  Google Scholar 

  • Coulaud, J.P., Larivière, M., Aziz, M.A., Gervais, M.C., Gaxotte, P., Deluol, A.M., and Cenas, J., 1984, Invermectin in onchocerciasis, Lancet 1:526–527.

    Article  Google Scholar 

  • Cuckler, A.C., Egerton, J.R., and Alicata, J.E., 1965, Therapeutic effect of thiabendazole on Angiostrongylus cantonensis infection in rats, J. Parasitol. 51:392–396.

    Article  PubMed  CAS  Google Scholar 

  • Denham, D.A., 1979, A review of methods for testing compounds for filaricidal activity, J. Helminthol. 53:175–187.

    Article  PubMed  CAS  Google Scholar 

  • Denham, D.A., 1980, Anthelmintic properties of flubendazole against Dipetalonema viteae in jirds, Trans. R. Soc. Trop. Med. Hyg. 74:829.

    Article  PubMed  CAS  Google Scholar 

  • Denham, D.A., 1982a, The effects of some avermectins on the growth of Brugia pahangi, Methods Findings Exp. Clin. Pharmacol. 4:347–350.

    CAS  Google Scholar 

  • Denham, D.A., 1982b, The methodology of screening for filarial activity using Brugia pahangi, in: Animal Models in Parasitology (D. Owen, ed.), pp. 93–104, Macmillan, London.

    Google Scholar 

  • Denham, D.A., and Mellor, P., 1976, The anthelmintic effects of a new compound “E” (Freidheim) on Onchocerca gutturosa in the cow — A possible tertiary screening system for drug action against O. volvulus in man, J Helminthol. 50:49–52.

    Article  PubMed  CAS  Google Scholar 

  • Denham, D.A., Suswillo, R.R., and Rogers, R., 1978, Studies with Brugia pahangi. 19. Anthelmintic effects of mebendazole, Trans. R. Soc. Trop. Med. Hyg. 72:546–641.

    Article  PubMed  CAS  Google Scholar 

  • Denham, D.A., Samad, R., Cho, S-Y., Suswillo, R.R., and Skippins, S.C., 1979, The anthelmintic effects of flubendazole on Brugia pahangi, Trans. R. Soc. Trop. Med. Hyg. 73:673–676.

    Article  PubMed  CAS  Google Scholar 

  • Denham, D.A., Liron, D.A., and Brandt, E., 1980, The anthelmintic effects of albendazole on Brugia pahangi, J. Helminthol. 54:199–200.

    Article  PubMed  CAS  Google Scholar 

  • Denham, D.A., Brandt, E., and Liron, D.A. 1981, Anthelmintic effects of oxibendazole on Brugia pahangi, J. Parasitol. 67:123

    Article  PubMed  CAS  Google Scholar 

  • Denham, D.A., Suswillo, R.R., and Chusattayanond, W., 1984, Parasitological observations on Meriones unguiculatus singly or multiply infected Brugia pahangi, Parasitology 88:295–301.

    PubMed  Google Scholar 

  • Dubey, J.P., 1979, Effect of fenbendazoie on Toxocara canis larvae in tissues of infected dogs, Am.J. Vet. Res. 40:698–699.

    PubMed  CAS  Google Scholar 

  • Duke, B.O.L., 1962, Experimental transmission of Onchocerca volvulus from man to a chimpanzee, Trans. R. Soc. Trop. Med. Hyg. 56:271.

    Google Scholar 

  • Duke, B.O.L., 1964, Studies on loiasis in monkey. IV. Experimental hybridization of the human and simian strains of Loa, Ann. Trop. Med. Parasitol. 58:390–408.

    PubMed  CAS  Google Scholar 

  • Duke, B.O.L., 1968, The effect of drugs on Onchocerca volvulus. 3. Trials of suramin at different dosages and a comparison of the brands Antrypol, Moramyl and Naganol, Bull. WHO 39:157–167.

    PubMed  CAS  Google Scholar 

  • Duke, B.O.L., 1970, The effects of drugs on Onchocerca volvulus. A trial of Malarsonyl potassium. Bulletin of the World Health Organization 42:115–117.

    PubMed  CAS  Google Scholar 

  • Duke, B.O.L., 1977, The effects of some drugs — Pentamidine, Stibocaptate, Hoechst 33258, F151, Compound “E” and Nifurtimox — on Onchocerca volvulus in chimpanzees, Tropenmed. Parasitol. 28:447–455.

    PubMed  CAS  Google Scholar 

  • Goodwin, L.G., 1984, Chemotherapy, Trans. R. Soc. Trop. Med. Hyg. (Suppl.) 78:1–8.

    Article  PubMed  CAS  Google Scholar 

  • Hawking, F., and Denham, D.A., 1976, The distribution of human filariasis throughout the world. Part 1. The pacific region; including New Guinea, Trop. Dis. Bull. 73:348–373.

    Google Scholar 

  • Hewitt, R.I., Kushner, S., Stewart, H.W., White, E., Wallace, W.S., and Subbarow, Y., 1947, Experimental chemotherapy of filariasis. III. Effect of l-diethyl-carbamyl-4-methylpiperazine hydrochloride against naturally acquired filarial infections in cotton rats and dogs, J. Lab. Clin. Med. 32:1314–1329.

    PubMed  CAS  Google Scholar 

  • Holt, P.E., Clarkson, M.J., and Kerslake, M., 1981, Anthelmintic tests on Toxocaris canis infection in mice, Vet. Rec. 108:308–309.

    Article  PubMed  CAS  Google Scholar 

  • Ishii, A.I., Terada, M., Kino, H., Hayashi, M., and Sano, M., 1983, Studies on chemotherapy of parasitic helminths: Effects of avermectin Bla on Angiostrongylus cantonensis in rats, Int. J. Parasitol. 13:491–498.

    Article  PubMed  CAS  Google Scholar 

  • Jenkins, D.C., and Carrington, T.S., 1981, An in vitro screening test for compounds active against the parenteral stages of Trichinella spiralis, Tropenmed. Parasitol. 32:31–34.

    PubMed  CAS  Google Scholar 

  • Kliks, M.M., Kroenke, K., and Hardman, J.M., 1982, Eosinophilic radiculomyeloencephalitis: An angiostrongyliasis outbreak in American Samoa related to ingestion of Achatina fulica snails, Am. J. Trop. Med. Hyg. 31:1114–1122.

    PubMed  CAS  Google Scholar 

  • McCracken, R.O., 1978, Efficacy of mebendazole and albendazole against Trichinella spiralis in mice, J. Parasitol. 64:214–219.

    Article  PubMed  CAS  Google Scholar 

  • Mazzoti, L., 1948, Posibilidad de utilizar como medio diagnostico auxiliar en la oncocercosis, las reacciones allergicas consecutivas a la administracion del “Hetrazan,” Rev. Inst. Sal. Enferm. Trop. 9:235–237.

    Google Scholar 

  • Muller, R., 1971, The possible mode of action of some chemotherapeutic agents in guinea worm disease, Trans. R. Soc. Trop. Med. Hyg. 65:843–844.

    Article  PubMed  CAS  Google Scholar 

  • Muller, R., 1979, Guinea worm disease: Epidemiology, control, and treatment, Bull. WHO 57:683–689.

    PubMed  CAS  Google Scholar 

  • Muller, R.L., and Nelson, G.S., 1975, Ackertia globulosa sp.n. (Nematoda: Filarioidea) from rodents in Kenya, J. Parasitol. 61:606–609.

    Article  PubMed  CAS  Google Scholar 

  • Narasimham, M.V.V.L., Roychowdhury, S.P., Das, M., and Rao, C.K., 1978, Levamisole and mebendazole in the treatment of Bancroftian infection, Southeast Asian J. Trop. Med. Publ. Health 9:571–575.

    CAS  Google Scholar 

  • Nicholas, W.L., and Stewart, A.C., 1979, The action of benzimidazoles on the larval stages of Toxocara canis in the mouse, Ann. Trop. Med. Parasitol. 73:57–62.

    PubMed  CAS  Google Scholar 

  • Ottesen, E. A., 1984, The action of diethylcarbamazine on adult worms of the lymphatic-dwelling filariae Wuchereria bancrofit, Brugia malayi and Brugia timori in man, WHO/FIL/84.174 pp. 1-24. (WHO document described as “not formal publication” but can be obtained from Geneva on request.)

    Google Scholar 

  • Partono, F., 1984, Filariasis in Indonesia: Clinical manifestations and basic concepts of treatment and control. Trans. R. Soc. Trop. Med. Hygi. 78:9–12.

    Article  CAS  Google Scholar 

  • Partono, F., Purnomo, and Soewarta, A., 1979, A simple method to control Brugia timori by diethylcarbamazine administration, Trans. R. Soc. Trop. Med. Hyg. 73:536–542.

    Article  PubMed  CAS  Google Scholar 

  • Partono, F., Purnomo, Soewarta, A., and Sri Oemijati, 1984, Low dosage diethylcarbamazine administered by villagers for the control of timorian filariasis, Trans. R. Soc. Trop. Med. Hyg. 78:370–372.

    Article  PubMed  CAS  Google Scholar 

  • Pawlowski, Z.S., 1983, Clinical aspects in man, in: Trichinella and Trichinosis (W. C. Campbell, ed.), pp. 367–401, Plenum Press, New York.

    Chapter  Google Scholar 

  • Rew, R.S., and Saz, J.F., 1977, The carbohydrate metabolism of Brugia pahangi micorilariae, J. Parasitol. 63:123–129.

    Article  PubMed  CAS  Google Scholar 

  • Rivas-Alcala, R., Mackenzie, C.D., Gomez-Rojo, E., Greene, B.M., and Taylor, H.R., 1984, The effects of diethylcarbamazine, mebendazole and levamisole on Onchocerca volvulus in vivo and in vitro, Tropenmed. Parasitol. 35:71–77.

    PubMed  CAS  Google Scholar 

  • Saeed, A.A., Green, P.J., Naoroz, M., Lee, H.A., and Venkat Ramon, G., 1984, Loa loa: the use of a blood cell separator to reduce microfilaraemia before specific chemotherapy, J. Infection 9:161–166.

    Article  CAS  Google Scholar 

  • Salazar-Mallen, M., Gonzalez-Barranco, D., and Del Carmen Moutes, H., 1971, Quinaoterapia de la oncocercosis con metrifonate, Rev. Inst. Med. Trop. Sao Paulo 13:363–368.

    PubMed  CAS  Google Scholar 

  • Santiago-Stevenson, D., Oliver-Gonzalez, J., and Hewitt, R.I., 1947, Treatment of filariasis bancrofti with l-diethylcarbamazine-4-methylpiperazine hydrochloride (“hetrazan”), J.A.M.A. 135:708–712.

    Article  CAS  Google Scholar 

  • Sastry, S.C., Kumar, J.K., and Lakshminarayana, V., 1978, The treatment of drancontiasis with thiabendazole, J. Trop. Med. Hyg. 81:32–35.

    PubMed  CAS  Google Scholar 

  • Shafei, A.Z., 1976, Preliminary report on the therapeutic effect of mebendazole in guinea worm infection, J. Trop. Med. Hyg. 79:197–200.

    PubMed  CAS  Google Scholar 

  • Stone, O.J., and Mullins, J.F., 1963, First use of thiabendazole in creeping eruption, Tex. Rep. Biol. Med. 21:422–424.

    PubMed  CAS  Google Scholar 

  • Suswillo, R.R., and Denham, D.A., 1977, A new system of testing for filaricidal activity using transplanted adult Brugia in the jird, J. Parasitol. 63:591–592.

    Article  PubMed  CAS  Google Scholar 

  • Suswillo, R.R., Nelson, G.S., Muller, R., McGreevy, P.B., Duke, B.O.L., and Denham, D.A., 1976, Attempts to infect jirds (Meriones unguiculatus) with Wuchereria bancrofti, Onchocerca volvulus, Loa loa and Mansonella ozzardi, J. Helminthol. 50:132–133.

    Google Scholar 

  • Thooris, G.C., 1956, Le traitement expérimental de la filariose a Wuchereria bancrofti en Oceanie Française par la suramine, Bull. Soc. Pathol. Exot. 49:1138–1157.

    CAS  Google Scholar 

  • Wilson, T., 1950, Hetrazan in the treatment of filariasis due to Wuchereria malayi, Trans. R. Soc. Trop. Med. Hyg. 44:49–66.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. London School of Hygiene & Tropical Medicine, London, WC1E 7HT, England

    David A. Denham

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  1. David A. Denham
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Editors and Affiliations

  1. Merck Institute for Therapeutic Research, Rahway, New Jersey, USA

    William C. Campbell

  2. Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey, USA

    Robert S. Rew

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© 1986 Plenum Press, New York

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Denham, D.A. (1986). Nematode Infections of Man: Extraintestinal Infections. In: Campbell, W.C., Rew, R.S. (eds) Chemotherapy of Parasitic Diseases. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1233-8_13

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  • DOI: https://doi.org/10.1007/978-1-4684-1233-8_13

  • Publisher Name: Springer, Boston, MA

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