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Alcohol-Induced Encephalopathy

  • Chapter
Cerebral Energy Metabolism and Metabolic Encephalopathy

Abstract

Ethyl alcohol through its effects on cerebral function has been a source of recreation to mankind for centuries and this has changed little over recent years. Despite a major effort, an understanding of the mechanism(s) by which ethanol exerts its central nervous system effects eludes medical research. This probably relates more to the complexity and inaccessibility of the human brain than to the nature of ethanol and its actions. The heterogeneity of the brain in terms of both macroanatomy and microanatomy confounds efforts at understanding the effects of agents such as ethanol. Are the changes observed in a given anatomical location following ethanol administration a direct consequence of ethanol effect, a change in electrical input to the region as a consequence of remote effects of ethanol, an effect of metabolites of ethanol, or a consequence of some more generalized effect such as altered blood flow, oxygen supply, or temperature change (Kalant, 1975)? Are any effects seen specific for ethanol or common to various neurodepressants? Are the changes seen causal or consequences of some other more basic effect? Questions such as these render research in this area both challenging and frustrating.

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Authors and Affiliations

  1. Departments of Medicine and Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78284, USA

    Roderick K. Roberts, Anastacio M. Hoyumpa Jr., George I. Henderson & Steven Schenker

  2. Research Service, Audie L. Murphy Memorial Veterans’ Hospital, San Antonio, Texas, 78284, USA

    Roderick K. Roberts, Anastacio M. Hoyumpa Jr., George I. Henderson & Steven Schenker

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  1. Roderick K. Roberts
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  2. Anastacio M. Hoyumpa Jr.
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  3. George I. Henderson
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  1. Department of Neurobiology and Anatomy, University of Texas Medical School at Houston, 77025, Houston, Texas, USA

    David W. McCandless

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Roberts, R.K., Hoyumpa, A.M., Henderson, G.I., Schenker, S. (1985). Alcohol-Induced Encephalopathy. In: McCandless, D.W. (eds) Cerebral Energy Metabolism and Metabolic Encephalopathy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1209-3_16

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