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Niacin-Nicotinamide Deficiency

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Cerebral Energy Metabolism and Metabolic Encephalopathy

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Abstract

Nicotinic acid (niacin) has been known for well over a century; however, the biological importance of this acid and its amide (nicotinamide) did not become apparent until the discovery of the pyridine nucleotides, NAD and NADP, and the recognition that this vitamin serves as a precursor of the pyridine nucleotide cofactors. The human disease caused by niacin deficiency is pellagra, a disease that filled insane asylums all over the world before its origin was discovered. The recognition of pellagra as an endemic disease in the United States dates from Searcy’s report in 1907 describing 88 cases of dementia in the Mount Vernon, Alabama, Insane Asylum. In spite of our extensive knowledge about the course of pellagra and our ability to eradicate this disease as a public health problem, there remain great gaps in our understanding of the exact relationship between niacin deficiency and specific pathological lesions in neural tissue.

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Authors and Affiliations

  1. Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland, 21201, USA

    Frederick C. Kauffman

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  1. Frederick C. Kauffman
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  1. Department of Neurobiology and Anatomy, University of Texas Medical School at Houston, 77025, Houston, Texas, USA

    David W. McCandless

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© 1985 Plenum Press, New York

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Kauffman, F.C. (1985). Niacin-Nicotinamide Deficiency. In: McCandless, D.W. (eds) Cerebral Energy Metabolism and Metabolic Encephalopathy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1209-3_13

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  • DOI: https://doi.org/10.1007/978-1-4684-1209-3_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1211-6

  • Online ISBN: 978-1-4684-1209-3

  • eBook Packages: Springer Book Archive

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