Skip to main content
SpringerLink
Log in
Book cover

Ganglioside Structure, Function, and Biomedical Potential pp 601–606Cite as

Multicentre Trial on Gangliosides in Diabetic Peripheral Neuropathy

  • Chapter

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 174))

Abstract

In spite of the reports on the therapy with pyridoxine, aldose reductase inhibitors,2–4 and myoinositol, 5,6; at present no specific treatment is available for diabetic peripheral neuropathy, the most frequent long-term complication of diabetes mellitus.

The trial has been carried out in collaboration with: A. Tiengo, P. Negrin (Padova), G. Pozza, N. Canal, G. C. Comi (Milano), G. F. Lenti, G. F. Pagano, L. Bergamini, W. Troni (Torino), F. Frigato, C. Ravenna, C. Mezzina (Mestre-Venezia), D. Massari, R. Gallato, M. Massarotti, R. Matano (Abano Terme), F. Grigoletto (Padova), H. Davis (Rochester), and M. Klein (New Jersey).

This is a preview of subscription content, log in via an institution.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. E. R. Levin, T. A. Hanscom, M. Fisher, W. A. Laustad, A. Lui, A. Ryan, D. Glokner, and S. R. Levin, The influence of pyridoxine in diabetic peripheral neuropathy, Diabetes Care 4:606 (1981).

    Article  PubMed  CAS  Google Scholar 

  2. K. H. Gabbay, N. Spack, S. Loo, J. L. Hirsh, and A. A. Ackil, Aldose reductase inhibition: studies with alrestatin, Metabolism 28(Suppl):471 (1979).

    Article  PubMed  CAS  Google Scholar 

  3. A. Culebras, J. Alio, and J. L. Herrera, Effect of aldose reductase inhibitor on diabetic peripheral neuropathy, Arch. Neurol. 38:133 (1981).

    Article  PubMed  CAS  Google Scholar 

  4. R. G. Judzerwitsch, J. B. Jaspan, K. S. Polonsky et al., Aldose reductase inhibition improves nerve conduction velocity in diabetic patients, New Engl. J. Med. 308:119 (1983).

    Article  Google Scholar 

  5. D. A. Greene, P. V. De Jesus, and A. I. Winegrad, Effects of insulin and dietary myoinositol on impaired peripheral motor nerve conduction velocity in acute streptozotocin diabetes, J. Clin. Invest. 55:1326 (1975).

    Article  PubMed  CAS  Google Scholar 

  6. R. S. Clements, Jr., B. Vaurganti, T. Kuba, S. J. Oh, and B. Darnell, Dietary myoinositol intake and peripheral nerve function in diabetic neuropathy, Metabolism 28:477 (1979).

    Article  PubMed  Google Scholar 

  7. A. Mingione, M. Monteleone, G. Paruzzi, O. Soragni, G. Cristiani, C. Moretti, W. Mega, and F. Scanabissi, Research in the cerebral gangliosides in neurolyses of the upper limb, Clin. Neurophysiol. 19:353 (1979).

    CAS  Google Scholar 

  8. S. Bassi, M. G. Albizzati, and L. Frattola, Electromyographic study of diabetic and alcoholic Polyneuropathic patients treated with gangliosides, Muscle & Nerve 5:351 (1982).

    Article  CAS  Google Scholar 

  9. B. Ceccarelli, F. Aporti, and M. Finesso, Effects of brain gangliosides on functional recovery in experimental regeneration and reinnervation, in: “Ganglioside Function,” G. Porcellati, B. Ceccarelli, and G. Tettamanti, eds., Plenum Press, New York and London (1976).

    Google Scholar 

  10. A. Gorio, G. Carmignoto, L. Facci, and M. Finesso, Motor nerve sprouting induced by gangliosides treatment. Possible indications for gangliosides on neuronal growth, Brain Res. 197:236 (1980).

    Article  PubMed  CAS  Google Scholar 

  11. A. Gorio, G. Carmignoto, and G. Ferrari, Axon sprouting stimulated by gangliosides. A new model for elongation and sprouting, in: “Gangliosides in Neurological and Neuromuscular Function, Development and Repair,” M. M. Rapport and A. Gorio, eds., Raven Press, New York (1981).

    Google Scholar 

  12. F. Norido, R. Canella, and F. Aporti, Acceleration of nerve regeneration by gangliosides estimated by the somatosensory evoked potentials, Experientia (Basel) 37:301 (1981).

    Article  CAS  Google Scholar 

  13. A. Gorio, P. Marini, and R. Zanoni, Muscle reinnervation III. Motoneuron sprouting capacity, enhancement by exogenous gangliosides, Neuroscience 8:417 (1983).

    Article  PubMed  CAS  Google Scholar 

  14. A. Gorio, F. Aporti, and F. Norido, Ganglioside treatment in experimental diabetic neuropathy, in: “Gangliosides in Neurological and Neuromuscular Function, Development and Repair,” M. M. Rapport and A. Gorio, eds., Raven Press, New York (1981).

    Google Scholar 

  15. A. Gorio, G. Carmignoto, G. Ferrari, F. Norido, M. G. Nunzi, R. Rubini, and R. Zanoni, Pharmacological aspects of experimental peripheral neuropathy, in: “International Conference on Peripheral Neuropathies,” S. Refsum, C. L. Bolis, and Portera-Sanchez, eds., Excerpta Medica, Amsterdam, Oxford-Princeton (1982).

    Google Scholar 

  16. F. Norido, R. Canella, and A. Gorio, Ganglioside treatment of neuropathy in diabetic mice, Muscle & Nerve 5:107 (1982).

    Article  CAS  Google Scholar 

  17. G. Pozza, V. Saibene, G. Comi, and N. Canal, The effect of ganglioside administration in human diabetic peripheral neuropathy, in: “Gangliosides in Neurological and Neuromuscular Function, Development and Repair,” M. M. Rapport and A. Gorio, eds., Raven Press, New York (1981).

    Google Scholar 

  18. J. W. Daly, The effect of gangliosides on activity of adenylate cyclase and phosphodiesterase from rat cerebral cortex, in: “Gangliosides in Neurological and Neuromuscular Function, Development and Repair,” M. M. Rapport and A. Gorio, eds., Raven Press, New York (1981).

    Google Scholar 

  19. A. Leon, L. Facci, G. Toffano, S. Sonnino, and G. Tettamanti, Activation of (Na+K+)ATPase by nanomolar concentrations of GM1 ganglioside, J. Neurochem. 37:350 (1981).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Internal Medicine, University of Padova, Italy

    Domenico Fedele & Gaetano Crepaldi

  2. Institute of Neurology, University of Padova, Italy

    Leontino Battistin

Authors
  1. Domenico Fedele
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gaetano Crepaldi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Leontino Battistin
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Albert Einstein College of Medicine, Bronx, New York, USA

    Robert W. Ledeen  & Kunihiko Suzuki  & 

  2. Yale University School of Medicine, New Haven, Connecticut, USA

    Robert K. Yu

  3. New York State Psychiatric Institute, New York, New York, USA

    Maurice M. Rapport

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Plenum Press, New York

About this chapter

Cite this chapter

Fedele, D., Crepaldi, G., Battistin, L. (1984). Multicentre Trial on Gangliosides in Diabetic Peripheral Neuropathy. In: Ledeen, R.W., Yu, R.K., Rapport, M.M., Suzuki, K. (eds) Ganglioside Structure, Function, and Biomedical Potential. Advances in Experimental Medicine and Biology, vol 174. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1200-0_51

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-1200-0_51

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1202-4

  • Online ISBN: 978-1-4684-1200-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation