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Ganglioside Structure, Function, and Biomedical Potential pp 489–497Cite as

Exogenous Gangliosides Enhance Recovery from CNS Injury

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 174))

Abstract

Since gangliosides are found in high concentration in the CNS1,2 and are topographically localized to the outer surface of neuronal membranes3,4, they have been implicated as receptor molecules. Some hypotheses suggest that gangliosides participate in the regulation of neurogenesis,5synaptogenesis,6 regeneration7 as well as cell-cell interaction.8 Reports that antibody to ganglioside can inhibit neurite outgrowth in vitro9,10 and can interfere with synaptogenesis and neurogenesis in vivo indirectly support these hypotheses.

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Author information

Authors and Affiliations

  1. Division of Neuroscience, New York State Psychiatric Institute and the Dept. of Psychiatry, College of Physicians & Surgeons, Columbia Univ., N.Y., N.Y., USA

    Stephen E. Karpiak

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  1. Stephen E. Karpiak
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Editors and Affiliations

  1. Albert Einstein College of Medicine, Bronx, New York, USA

    Robert W. Ledeen  & Kunihiko Suzuki  & 

  2. Yale University School of Medicine, New Haven, Connecticut, USA

    Robert K. Yu

  3. New York State Psychiatric Institute, New York, New York, USA

    Maurice M. Rapport

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© 1984 Plenum Press, New York

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Karpiak, S.E. (1984). Exogenous Gangliosides Enhance Recovery from CNS Injury. In: Ledeen, R.W., Yu, R.K., Rapport, M.M., Suzuki, K. (eds) Ganglioside Structure, Function, and Biomedical Potential. Advances in Experimental Medicine and Biology, vol 174. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1200-0_41

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  • DOI: https://doi.org/10.1007/978-1-4684-1200-0_41

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1202-4

  • Online ISBN: 978-1-4684-1200-0

  • eBook Packages: Springer Book Archive

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