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Effects of Gangliosides on the Functional Recovery of Damaged Brain

  • G. Toffano
  • G. Savoini
  • C. Aldinio
  • G. Valenti
  • R. Dal Toso
  • A. Leon
  • L. Calza
  • I. Zini
  • L. F. Agnati
  • K. Fuxe
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 174)

Abstract

Treatment of brain and spinal cord injuries is usually undertaken with the tacit assumption that anatomical repair is not possible. This view implies serious limitations for the comprehension of phenomena such as neuronal plasticity and functional recovery of mature CNS. Currently however neuronal circuitries are envisaged as highly adaptable structures, intrinsically capable of remodeling and establishing new functional connections not only during development but also in the mature brain in response to perturbations such as lesions,1,2The failure of regeneration in the mature central nervous tissues may then rather be due to the incapability of growing axon sprouts to elongate and find a pathway to the denervated target.3

Keywords

Tyrosine Hydroxylase Substantia Nigra Dopaminergic Neuron Septal Lesion Striatal Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • G. Toffano
    • 1
  • G. Savoini
    • 1
  • C. Aldinio
    • 1
  • G. Valenti
    • 1
  • R. Dal Toso
    • 1
  • A. Leon
    • 1
  • L. Calza
    • 2
  • I. Zini
    • 2
  • L. F. Agnati
    • 2
  • K. Fuxe
    • 3
  1. 1.Department of BiochemistryFidia Research LaboratoriesAbano TermeItaly
  2. 2.Institute of Human PhysiologyUniversity of ModenaModenaItaly
  3. 3.Department of HistologyKarolinska InstitutetStockholmSweden

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