Antibodies to Glycosphingolipids in Patients with Multiple Sclerosis and SLE
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Antibodies against gangliosides and neutral glycosphingolipids (GSLs) have been reported previously in the sera of patients with multiple sclerosis (MS)1-5 and systemic lupus erythematosus (SLE). The specificity of these antibodies has not been examined in detail, and in studies in which a liposome lysis assay was used the lytic factor in serum was not clearly identified as an immunoglobulin. The long term objectives of this study are to characterize the specificity of anti-GSL antibodies, to determine their incidence in immunological and non-immunological diseases that affect the nervous system, and to examine the temporal fluctuation of antibody levels in relation to disease activity. In this report we present our initial findings on the incidence and specificity of anti-GSL antibodies.
KeywordsMultiple Sclerosis Systemic Lupus Erythematosus Multiple Sclerosis Patient Systemic Lupus Erythematosus Patient Brain Ganglioside
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