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Immunological Expression of Gangliosides in Multiple Sclerosis and in a Demyelinating Model Disease in Rabbits

  • Ben-Ami Sela
  • Halina Offner
  • Gregory Konat
  • Varda Lev-Ram
  • Oded Cohen
  • Irun R. Cohen
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 174)

Abstract

Multiple sclerosis (MS) is a neurological disease of an unknown aetiology characterized by the destruction of myelin in the central nervous system (CNS). One possible mechanism implicated in the process of demyelination and plaque formation is an autoimmune response to a nervous system antigen(s), and the search continues to identify myelin components which might provoke such postulated autoimmune reactions. T-cell-dependent cellular immunity has been suggested as playing a role in the pathogenesis of MS,1,2 as shown in numerous reports on the specific sensitization of peripheral blood lymphocytes from MS patients to myelin basic protein. Similarly, a humoral (B cell) response against myelin glycolipid components, such as galactocerebroside3 and galactosyl digly-ceride,4 were also investigated. Studies on the possible involvement of myelin gangliosides as potential target antigens in the pathological autoimmune process in MS are presently summarized. These studies were initiated following reports on the emergence of anti-ganglioside antibodies in sera of MS patients5,6 and by the consideration that gangliosides are exclusively located on the external (intraperiod line) apposition of myelin, and are thus rendered accessible for an autoimmune attack.

Keywords

Multiple Sclerosis Multiple Sclerosis Patient Myelin Basic Protein Optic Neuritis Control Rabbit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Ben-Ami Sela
    • 1
  • Halina Offner
    • 2
  • Gregory Konat
    • 2
  • Varda Lev-Ram
    • 3
  • Oded Cohen
    • 3
  • Irun R. Cohen
    • 3
  1. 1.Departments of BiophysicsThe Weizmann Institute of ScienceRehovotIsrael
  2. 2.Cell BiologyThe Weizmann Institute of ScienceRehovotIsrael
  3. 3.The Neurochemical InstituteCopenhagenDenmark

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