Specific Gangliosides are Receptors for Sendai Virus
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Sendai virus (also known as the Hemagglutinating Virus of Japan, HVJ) is a member of the family Paramyxoviridae. This virus along with select other members of the same family such as measles and Newcastle disease viruses have the remarkable ability to induce membrane fusion in the neutral to slightly alkaline pH range normally found at the cell surface. This ability is used by Sendai virus to initiate infection. Infectious viral particles (virions) recognize specific receptors on the host cell surface and, through interaction with these receptors, enable the viral membrane to fuse with the surface membrane of the host, thereby releasing the viral nucleocapsid directly into the cytoplasm to continue the infectious process.1 Noninfectious viral particles also bind and enter the cell, but do so by adsorptive endocytosis which results in their subsequent degradation.2
KeywordsNewcastle Disease Virus MDCK Cell Membrane Fusion Sendai Virus Roller Bottle
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