Gangliosides, The Thyrotropin Receptor, and Autoimmune Thyroid Disease
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The interaction of thyrotropin (TSH)* with a specific receptor on the thyroid cell surface induces changes in adenylate cyclase activity which result in enhanced iodide uptake, thyroglobulin biosynthesis, iodination of thyroglobulin, degradation of iodinated thyroglobulin to form thyroid hormone, and the release of thyroid hormone (T3 and T4) into the blood stream. Although changes in all of the above activities have been and can be used to define receptor function, definition of the structure of the TSH receptor on a molecular level, has required the identification of specific membrane components using binding studies and 125I-labeled hormone.
KeywordsCholera Toxin Adenylate Cyclase Activity Thyroid Cell Thyrotropin Receptor Iodide Uptake
- FRTL-5 cells
functioning rat thyroid cells derived from normal Fisher rat thyroid glands
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