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Gangliosides, The Thyrotropin Receptor, and Autoimmune Thyroid Disease

  • Paolo Lacetti
  • Donatella Tombaccini
  • Salvatore Aloj
  • Evelyn F. Grollman
  • Leonard D. Kohn
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 174)

Abstract

The interaction of thyrotropin (TSH)* with a specific receptor on the thyroid cell surface induces changes in adenylate cyclase activity which result in enhanced iodide uptake, thyroglobulin biosynthesis, iodination of thyroglobulin, degradation of iodinated thyroglobulin to form thyroid hormone, and the release of thyroid hormone (T3 and T4) into the blood stream. Although changes in all of the above activities have been and can be used to define receptor function, definition of the structure of the TSH receptor on a molecular level, has required the identification of specific membrane components using binding studies and 125I-labeled hormone.

Keywords

Cholera Toxin Adenylate Cyclase Activity Thyroid Cell Thyrotropin Receptor Iodide Uptake 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

TSH

thyrotropin

FRTL-5 cells

functioning rat thyroid cells derived from normal Fisher rat thyroid glands

T3

triiodothyronine

T4

thyroxine

CBA

cytochemical bioassay

TSAb

thyroid-stimulating antibody

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References

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Paolo Lacetti
    • 1
  • Donatella Tombaccini
    • 1
  • Salvatore Aloj
    • 1
  • Evelyn F. Grollman
    • 1
  • Leonard D. Kohn
    • 1
  1. 1.Section on Biochemistry of Cell Regulation, Laboratory of Biochemical PharmacologyNational Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases National Institutes of HealthBethesdaUSA

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