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Ganglioside Alterations in the Genetically-Determined Hypertrophic Neuropathy of the Murine Neurological Mutant Trembler

  • Marie-Luce Harpin
  • Jacques Portoukalian
  • Bernard Zalc
  • Nicole Baumann
Chapter
  • 86 Downloads
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 174)

Abstract

Hypertrophic neuropathy is a standard pathological reaction of peripheral nerve that occurs in different diseases. On transverse sections, it is characterized by onion-bulb disposition of proliferated Schwann cells around nerve fibers. These hypertrophic onion-bulb changes were first recognized in the hereditary neuropathies. Until recently, they were considered specific for Dejerine-Sottas disease, but from clinical and experimental studies they are known to be the non-specific consequence of Schwann cell proliferation resulting from repeated segmental demyelination and remyelination.1

Keywords

Peripheral Nerve Sciatic Nerve Schwann Cell Neuraminic Acid Hereditary Neuropathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Marie-Luce Harpin
    • 1
  • Jacques Portoukalian
    • 1
    • 2
  • Bernard Zalc
    • 1
  • Nicole Baumann
    • 1
  1. 1.Laboratoire de NeurochimieINSERM U. 134Paris Cedex 13France
  2. 2.Laboratoire d’Immunologie Centre Leon BerardLyonFrance

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