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Ganglioside Structure, Function, and Biomedical Potential pp 273–284Cite as

New Approaches in the Study of Ganglioside Metabolism

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 174))

Abstract

It is generally accepted that gangliosides are biosynthesized in the Golgi apparatus and then move to the plasma membrane which is the main site of their cellular location. 1–3 The process of ganglioside biosynthesis consists of sequential additions of monosaccharide units to a starting precursor (ceramide or psychosine) catalyzed by specific glycosyltransferases.1, 2, 4, 5 Gangliosides are degraded in the lysosomes, where several glycohydrolases remove sequentially the individual saccharide units and the formed ceramide is split by ceramidase into sphingosine and fatty acid.6–8 In the case of nerve cells the process of both biosynthesis and degradation of gangliosides is assumed to occur primarily in the perikaryon.7–9 Transport of gangliosides to and from the plasma membranes is mediated by fast axonal flow.9, 10

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Abbreviations

DDQ:

2,3-dichloro-5,6-dicyanobenzoquinone

TLC:

thin layer chromatography

HPTLC:

high performance thin layer chromatography

GLC:

gas-liquid chromatography

HPLC:

high performance liquid chromatography

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Author information

Authors and Affiliations

  1. Dept. of Biological Chemistry, the Medical School University of Milan, Milan, Italy

    G. Tettamanti, R. Ghidoni, S. Sonnino, V. Chigorno, B. Venerando, A. Giuliani & A. Fiorilli

Authors
  1. G. Tettamanti
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  2. R. Ghidoni
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  3. S. Sonnino
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  4. V. Chigorno
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  5. B. Venerando
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  6. A. Giuliani
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  7. A. Fiorilli
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Editor information

Editors and Affiliations

  1. Albert Einstein College of Medicine, Bronx, New York, USA

    Robert W. Ledeen  & Kunihiko Suzuki  & 

  2. Yale University School of Medicine, New Haven, Connecticut, USA

    Robert K. Yu

  3. New York State Psychiatric Institute, New York, New York, USA

    Maurice M. Rapport

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© 1984 Plenum Press, New York

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Tettamanti, G. et al. (1984). New Approaches in the Study of Ganglioside Metabolism. In: Ledeen, R.W., Yu, R.K., Rapport, M.M., Suzuki, K. (eds) Ganglioside Structure, Function, and Biomedical Potential. Advances in Experimental Medicine and Biology, vol 174. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1200-0_23

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  • DOI: https://doi.org/10.1007/978-1-4684-1200-0_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1202-4

  • Online ISBN: 978-1-4684-1200-0

  • eBook Packages: Springer Book Archive

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