Incorporation Rate of GM1 Ganglioside into Mouse Brain Myelin: Effect of Aging and Modification by Hormones and other Compounds

  • Susumu Ando
  • Yasukazu Tanaka
  • Yuriko Ono
  • Kazuo Kon
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 174)


Myelin formation in the rat brain is activated at a particular postnatal age of between two to five weeks, and the rate is remarkably reduced to very low level in adulthood.1 Hence, myelin once formed had been considered to be metabolically inactive or stable. However, it has been found that considerable incorporation of newly synthesized material into myelin still occurs after the active myelinogenesis period.2 Structural features of myelin membranes may limit the replacement of the constituents or the remodeling of the membranes, and indeed, the turnover of myelin components was reported to be much slower than those of the corresponding molecules in microsomes.2, 3 The metabolic activity of GM1 ganglioside in myelin of young rat brain was compared with the activity in the whole brain by Suzuki,4 who demonstrated that the labeled GM1 accumulated at a slower rate in myelin for the first one month after the injection of radioactive glucosamine.


Sialic Acid Incorporation Rate Deuterium Oxide High Performance Liquid Chroma Neuraminic Acid 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Susumu Ando
    • 1
  • Yasukazu Tanaka
    • 1
  • Yuriko Ono
    • 1
  • Kazuo Kon
    • 1
  1. 1.Department of BiochemistryTokyo Metropolitan Institute of GerontologyItabashi-ku, TokyoJapan

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