Incorporation Rate of GM1 Ganglioside into Mouse Brain Myelin: Effect of Aging and Modification by Hormones and other Compounds
- 92 Downloads
Myelin formation in the rat brain is activated at a particular postnatal age of between two to five weeks, and the rate is remarkably reduced to very low level in adulthood.1 Hence, myelin once formed had been considered to be metabolically inactive or stable. However, it has been found that considerable incorporation of newly synthesized material into myelin still occurs after the active myelinogenesis period.2 Structural features of myelin membranes may limit the replacement of the constituents or the remodeling of the membranes, and indeed, the turnover of myelin components was reported to be much slower than those of the corresponding molecules in microsomes.2, 3 The metabolic activity of GM1 ganglioside in myelin of young rat brain was compared with the activity in the whole brain by Suzuki,4 who demonstrated that the labeled GM1 accumulated at a slower rate in myelin for the first one month after the injection of radioactive glucosamine.
KeywordsSialic Acid Incorporation Rate Deuterium Oxide High Performance Liquid Chroma Neuraminic Acid
Unable to display preview. Download preview PDF.
- 2.J. A. Benjamins and M. E. Smith, Metabolism of myelin, in: “Myelin,” P. Morell, ed., Plenum Press, N.Y. (1977).Google Scholar
- 6.Y. Tanaka and S. Ando, Increased stearate formation by chain elongation in streptozotocin diabetic mice: Compensation for decreased de novo fatty acid synthesis, Biomed. Res. 2:404 (1981).Google Scholar
- 18.Y. Ono, S. Ando, Y. Tanaka, and R. W. Ledeen, Myelin metabolism and aging, Proc. Jap. Conf. Biochem. Lipids 24:353 (1982).Google Scholar