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An Outline of Ganglioside Metabolism

  • Chapter
Ganglioside Structure, Function, and Biomedical Potential

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 174))

Abstract

Gangliosides are mainly located in the cell plasma membrane and are asymmetrically disposed on the outer membrane leaflet. Their hydrophobic portion (the ceramide) is inserted into the membrane layer and the oligosaccharide moiety protrudes on the membrane surface. Very small amounts of ganglioside are also present in intracellular structures and compartments. These gangliosides are likely the expression of the transient forms moving from the site of biosynthesis to the plasma membrane or migrating from the plasma membrane to the site of degradation. They constitute a small “metabolic” pool as compared to the large “final residence” pool.

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Authors and Affiliations

  1. Department of Biological Chemistry, The Medical School University of Milan, Via Saldini 50, 20133, Milan, Italy

    G. Tettamanti

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  1. G. Tettamanti
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Editors and Affiliations

  1. Albert Einstein College of Medicine, Bronx, New York, USA

    Robert W. Ledeen  & Kunihiko Suzuki  & 

  2. Yale University School of Medicine, New Haven, Connecticut, USA

    Robert K. Yu

  3. New York State Psychiatric Institute, New York, New York, USA

    Maurice M. Rapport

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© 1984 Plenum Press, New York

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Tettamanti, G. (1984). An Outline of Ganglioside Metabolism. In: Ledeen, R.W., Yu, R.K., Rapport, M.M., Suzuki, K. (eds) Ganglioside Structure, Function, and Biomedical Potential. Advances in Experimental Medicine and Biology, vol 174. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1200-0_17

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  • DOI: https://doi.org/10.1007/978-1-4684-1200-0_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1202-4

  • Online ISBN: 978-1-4684-1200-0

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