Wonders in Glycolipids — A Historical View

  • Tamio Yamakawa
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 174)


It is my great privilege to present the opening lecture at this very exciting meeting. The organizer, Dr. Ledeen, suggested a historical outline of glycolipid research as an introduction, and I hope you will allow me to talk freely as I outline some of the thoughts and questions that have occured to me during my 30 years of research in this field.


Sialic Acid Neuraminic Acid Neutral Glycolipid Opening Lecture Bovine Submaxillary Mucin 
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  1. 1.
    J. L. W. Thudichum, A treatise on the chemical constitution of the brain, Bailliere, Tindall and Cox, London (1884).Google Scholar
  2. 2.
    T. Uchida, K. Takahashi, H. Yamaguchi, and Y. Nagai, Localization of galactocerebroside in oligodendrocytes, myelin sheath and choroid plexus, Japan J. Exp. Med. 51:29 (1981).Google Scholar
  3. 3.
    K. Sakakibara, T. Momoi, T. Uchida, and Y. Nagai, Evidence for association of glycosphingolipid with a colchicine-sensitive microtubule-like cytoskeletal structure of cultured cells, Nature 293:76 (1981).PubMedCrossRefGoogle Scholar
  4. 4.
    S. Abrahamsson, B. Dahlen, H. Lofgren, I. Pascher, and S. Sundell, Molecular arrangement and conformation of lipids of relevance to membrane structure, in: “Structure of Biological Membranes”, S. Abrahamsson and I. Pascher, eds., Plenum Press, New York and London (1977).CrossRefGoogle Scholar
  5. 5.
    W. Koch, Zur kenntnis der schwefelverbindugen des nerven systems, Z. Physiol. Chem. 53:496 (1907).CrossRefGoogle Scholar
  6. 6.
    G. Blix, Zur kenntnis der schwefelhaltigen lipoidstoffe des gehirns. Uber cerebronschwefelsaure, Z. Physiol. Chem. 219:82 (1933).CrossRefGoogle Scholar
  7. 7.
    T. Nakayama, Studies on the conjugated lipids. II. On cerebron sulphuric acid, J. Biochem. 38:157 (1951).Google Scholar
  8. 8.
    S. J. Thannhauser, J. Fellig, and G. Schmidt, The structure of cerebroside sulfuric ester of beef brain, J. Biol. Chem. 215:211 (1955).PubMedGoogle Scholar
  9. 9.
    T. Yamakawa, N. Kiso, S. Handa, A. Makita, and S. Yokoyama, On the structure of brain cerebroside sulfuric ester and ceramide dihexoside of erythrocytes, J. Biochem. 52:226 (1962).PubMedGoogle Scholar
  10. 10.
    P. J. Stoffyn and A. Stoffyn, Structure of sulfatides, Biochim. Biophys. Acta 70:218 (1963).PubMedCrossRefGoogle Scholar
  11. 11.
    I. Ishizuka, A. Suzuki, and T. Yamakawa, Isolation and characterization of a novel sulfoglycolipid, “Seminolipid”, from boar testis and spermatozoa, J. Biochem. 73:77 (1973).PubMedGoogle Scholar
  12. 12.
    M. Kates, B. Palamenta, M. B. Perry, and G. A. Adams, A new glycolipid sulfate ester in Halobacterium cutirubrum, Biochim. Biophys. Acta 137:213 (1967).PubMedGoogle Scholar
  13. 13.
    E. Klenk, Uber die natur der phosphatide und anderer lipoide des gehirns und der leber bei der Niemann-Pickschen Krankheit (12. Mitteilung uber phosphatide), Z. Physiol. Chem. 235:24 (1935).CrossRefGoogle Scholar
  14. 14.
    E. Walz, Uber das vorkommen von kerasin in der normalen rindermilz, Z. Physiol. Chem. 166:210 (1927).CrossRefGoogle Scholar
  15. 15.
    P. A. Levene and K. Landsteiner, On some new lipids, J. Biol. Chem. 75:607 (1927).Google Scholar
  16. 16.
    E. Klenk, Beitrage zur chemie der lipoidosen (3. Mitteilung) Niemann-Picksche Krankheit und amaurotische Idiotie, Z. Physiol. Chem. 262:128 (1939).CrossRefGoogle Scholar
  17. 17.
    G. Blix, Einige beobachtungen uber eine hexosaminhaltige substanz in der protagonfraktion des gehirns, Skand. Arch. Physiol. 80:46 (1938).Google Scholar
  18. 18.
    E. Klenk, Uber die ganglioside, eine neue gruppe von zukerhaltigen gehirnlipoiden, Z. Physiol. Chem. 273:76 (1941).CrossRefGoogle Scholar
  19. 19.
    E. Klenk, Neuraminsaure, das spaltprodukt eines neuen gehirnlipoids, Z. Physiol. Chem. 268:50 (1942).CrossRefGoogle Scholar
  20. 20.
    G. Blix, Uber die kohlenhydratgruppen des submaxillarismucins, Z. Physiol. Chem. 240:43 (1936).CrossRefGoogle Scholar
  21. 21.
    T. Yamakawa and S. Suzuki, The chemistry of the lipids of posthemolytic residue or stroma of erythrocytes. III. On the structure of hemataminic acid, J. Biochem. 39:175 (1952).Google Scholar
  22. 22.
    E. Klenk, H. Faillard, F. Weygand, and H. H. Schone, Untersuchungen uber die konstitution der neuraminsaure, Z. Physiol. Chem. 304:35 (1956).CrossRefGoogle Scholar
  23. 23.
    A. Gottshalk, Structural relationship between sialic acid, neuraminic acid and 2-carboxy-pyrrole, Nature (London) 176:881 (1955).CrossRefGoogle Scholar
  24. 24.
    L. Svennerholm, Partition chromatography of brain in gangliosides on cellulose, Acta Chem. Scand. 8:1108 (1954).CrossRefGoogle Scholar
  25. 25.
    R. Kuhn and H. Wiegandt, Die konstitution der ganglioside GII, GIII und GIV, Z. Naturforsch. 18b:541 (1963).Google Scholar
  26. 26.
    T. Yamakawa and S. Suzuki, The chemistry of the lipids of posthemolytic residue or stroma of erythrocytes. I. Concerning the ether-insoluble lipids of lyophilized horse blood stroma, J. Biochem. 38:199 (1951).Google Scholar
  27. 27.
    E. Klenk and K. Lauenstein, Uber die zuckerhaltigen lipoid der formbestandteile des menschlichen blutes, Z. Physiol. Chem. 288:220 (1951).Google Scholar
  28. 28.
    T. Yamakawa and S. Suzuki, The chemistry of the lipids of posthemolytic residue or stroma of erythrocytes. III. Globosides, the sugar-containing lipid of human blood stroma, J. Biochem. 39:393 (1952).Google Scholar
  29. 29.
    T. Yamakawa, Glycolipids of mammalian red blood cells, in: “Lipoide” Shutte, ed., 16. Colloquium der Gesell. Physiol. Chem. in Mosbach. (1965).Google Scholar
  30. 30.
    T. Yamakawa and Y. Nagai, Glycolipid at the cell surface and their biological functions, Trends Biochem. Sci. 3:128 (1978).CrossRefGoogle Scholar
  31. 31.
    T. Yamakawa and T. Iida, Immunological study on the red blood cells. I. Globoside as the agglutinogen of the ABO system on erythrocytes, Japan J. Exp. Med. 23:327 (1953).Google Scholar
  32. 32.
    B. Siddiqui and S. Hakomori, A revised structure for the Forssman glycolipid hapten, J. Biol. Chem. 246:5766 (1971).PubMedGoogle Scholar
  33. 33.
    M. Naiki and D. M. Marcus, An immunochemical study of the human blood group Il, P, and Pk glycosphingolipid antigens, Biochemistry 14:4837 (1975).PubMedCrossRefGoogle Scholar
  34. 34.
    T. Feizi, E. A. Kabat, G. Vicari, B. Anderson, and W. L. Marsh, Immunological studies on blood groups, XIX. The I antigen complex: Specificity differences among anti-I sera revealed by quantitative precipitin studies; Partial structure of the I determinant specific for one anti-I serum, J. Immunol. 106:1578 (1971).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Tamio Yamakawa
    • 1
  1. 1.Tokyo Metropolitan Institute of Medical Science HonkomagomeBunkyo-ku, TokyoJapan

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