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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 174))

Abstract

It is my great privilege to present the opening lecture at this very exciting meeting. The organizer, Dr. Ledeen, suggested a historical outline of glycolipid research as an introduction, and I hope you will allow me to talk freely as I outline some of the thoughts and questions that have occured to me during my 30 years of research in this field.

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References

  1. J. L. W. Thudichum, A treatise on the chemical constitution of the brain, Bailliere, Tindall and Cox, London (1884).

    Google Scholar 

  2. T. Uchida, K. Takahashi, H. Yamaguchi, and Y. Nagai, Localization of galactocerebroside in oligodendrocytes, myelin sheath and choroid plexus, Japan J. Exp. Med. 51:29 (1981).

    CAS  Google Scholar 

  3. K. Sakakibara, T. Momoi, T. Uchida, and Y. Nagai, Evidence for association of glycosphingolipid with a colchicine-sensitive microtubule-like cytoskeletal structure of cultured cells, Nature 293:76 (1981).

    Article  PubMed  CAS  Google Scholar 

  4. S. Abrahamsson, B. Dahlen, H. Lofgren, I. Pascher, and S. Sundell, Molecular arrangement and conformation of lipids of relevance to membrane structure, in: “Structure of Biological Membranes”, S. Abrahamsson and I. Pascher, eds., Plenum Press, New York and London (1977).

    Chapter  Google Scholar 

  5. W. Koch, Zur kenntnis der schwefelverbindugen des nerven systems, Z. Physiol. Chem. 53:496 (1907).

    Article  Google Scholar 

  6. G. Blix, Zur kenntnis der schwefelhaltigen lipoidstoffe des gehirns. Uber cerebronschwefelsaure, Z. Physiol. Chem. 219:82 (1933).

    Article  CAS  Google Scholar 

  7. T. Nakayama, Studies on the conjugated lipids. II. On cerebron sulphuric acid, J. Biochem. 38:157 (1951).

    CAS  Google Scholar 

  8. S. J. Thannhauser, J. Fellig, and G. Schmidt, The structure of cerebroside sulfuric ester of beef brain, J. Biol. Chem. 215:211 (1955).

    PubMed  CAS  Google Scholar 

  9. T. Yamakawa, N. Kiso, S. Handa, A. Makita, and S. Yokoyama, On the structure of brain cerebroside sulfuric ester and ceramide dihexoside of erythrocytes, J. Biochem. 52:226 (1962).

    PubMed  CAS  Google Scholar 

  10. P. J. Stoffyn and A. Stoffyn, Structure of sulfatides, Biochim. Biophys. Acta 70:218 (1963).

    Article  PubMed  CAS  Google Scholar 

  11. I. Ishizuka, A. Suzuki, and T. Yamakawa, Isolation and characterization of a novel sulfoglycolipid, “Seminolipid”, from boar testis and spermatozoa, J. Biochem. 73:77 (1973).

    PubMed  CAS  Google Scholar 

  12. M. Kates, B. Palamenta, M. B. Perry, and G. A. Adams, A new glycolipid sulfate ester in Halobacterium cutirubrum, Biochim. Biophys. Acta 137:213 (1967).

    PubMed  CAS  Google Scholar 

  13. E. Klenk, Uber die natur der phosphatide und anderer lipoide des gehirns und der leber bei der Niemann-Pickschen Krankheit (12. Mitteilung uber phosphatide), Z. Physiol. Chem. 235:24 (1935).

    Article  CAS  Google Scholar 

  14. E. Walz, Uber das vorkommen von kerasin in der normalen rindermilz, Z. Physiol. Chem. 166:210 (1927).

    Article  CAS  Google Scholar 

  15. P. A. Levene and K. Landsteiner, On some new lipids, J. Biol. Chem. 75:607 (1927).

    CAS  Google Scholar 

  16. E. Klenk, Beitrage zur chemie der lipoidosen (3. Mitteilung) Niemann-Picksche Krankheit und amaurotische Idiotie, Z. Physiol. Chem. 262:128 (1939).

    Article  CAS  Google Scholar 

  17. G. Blix, Einige beobachtungen uber eine hexosaminhaltige substanz in der protagonfraktion des gehirns, Skand. Arch. Physiol. 80:46 (1938).

    CAS  Google Scholar 

  18. E. Klenk, Uber die ganglioside, eine neue gruppe von zukerhaltigen gehirnlipoiden, Z. Physiol. Chem. 273:76 (1941).

    Article  Google Scholar 

  19. E. Klenk, Neuraminsaure, das spaltprodukt eines neuen gehirnlipoids, Z. Physiol. Chem. 268:50 (1942).

    Article  Google Scholar 

  20. G. Blix, Uber die kohlenhydratgruppen des submaxillarismucins, Z. Physiol. Chem. 240:43 (1936).

    Article  CAS  Google Scholar 

  21. T. Yamakawa and S. Suzuki, The chemistry of the lipids of posthemolytic residue or stroma of erythrocytes. III. On the structure of hemataminic acid, J. Biochem. 39:175 (1952).

    CAS  Google Scholar 

  22. E. Klenk, H. Faillard, F. Weygand, and H. H. Schone, Untersuchungen uber die konstitution der neuraminsaure, Z. Physiol. Chem. 304:35 (1956).

    Article  CAS  Google Scholar 

  23. A. Gottshalk, Structural relationship between sialic acid, neuraminic acid and 2-carboxy-pyrrole, Nature (London) 176:881 (1955).

    Article  Google Scholar 

  24. L. Svennerholm, Partition chromatography of brain in gangliosides on cellulose, Acta Chem. Scand. 8:1108 (1954).

    Article  Google Scholar 

  25. R. Kuhn and H. Wiegandt, Die konstitution der ganglioside GII, GIII und GIV, Z. Naturforsch. 18b:541 (1963).

    CAS  Google Scholar 

  26. T. Yamakawa and S. Suzuki, The chemistry of the lipids of posthemolytic residue or stroma of erythrocytes. I. Concerning the ether-insoluble lipids of lyophilized horse blood stroma, J. Biochem. 38:199 (1951).

    CAS  Google Scholar 

  27. E. Klenk and K. Lauenstein, Uber die zuckerhaltigen lipoid der formbestandteile des menschlichen blutes, Z. Physiol. Chem. 288:220 (1951).

    CAS  Google Scholar 

  28. T. Yamakawa and S. Suzuki, The chemistry of the lipids of posthemolytic residue or stroma of erythrocytes. III. Globosides, the sugar-containing lipid of human blood stroma, J. Biochem. 39:393 (1952).

    CAS  Google Scholar 

  29. T. Yamakawa, Glycolipids of mammalian red blood cells, in: “Lipoide” Shutte, ed., 16. Colloquium der Gesell. Physiol. Chem. in Mosbach. (1965).

    Google Scholar 

  30. T. Yamakawa and Y. Nagai, Glycolipid at the cell surface and their biological functions, Trends Biochem. Sci. 3:128 (1978).

    Article  CAS  Google Scholar 

  31. T. Yamakawa and T. Iida, Immunological study on the red blood cells. I. Globoside as the agglutinogen of the ABO system on erythrocytes, Japan J. Exp. Med. 23:327 (1953).

    CAS  Google Scholar 

  32. B. Siddiqui and S. Hakomori, A revised structure for the Forssman glycolipid hapten, J. Biol. Chem. 246:5766 (1971).

    PubMed  CAS  Google Scholar 

  33. M. Naiki and D. M. Marcus, An immunochemical study of the human blood group Il, P, and Pk glycosphingolipid antigens, Biochemistry 14:4837 (1975).

    Article  PubMed  CAS  Google Scholar 

  34. T. Feizi, E. A. Kabat, G. Vicari, B. Anderson, and W. L. Marsh, Immunological studies on blood groups, XIX. The I antigen complex: Specificity differences among anti-I sera revealed by quantitative precipitin studies; Partial structure of the I determinant specific for one anti-I serum, J. Immunol. 106:1578 (1971).

    PubMed  CAS  Google Scholar 

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© 1984 Plenum Press, New York

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Yamakawa, T. (1984). Wonders in Glycolipids — A Historical View. In: Ledeen, R.W., Yu, R.K., Rapport, M.M., Suzuki, K. (eds) Ganglioside Structure, Function, and Biomedical Potential. Advances in Experimental Medicine and Biology, vol 174. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1200-0_1

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  • DOI: https://doi.org/10.1007/978-1-4684-1200-0_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1202-4

  • Online ISBN: 978-1-4684-1200-0

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