Abstract
A localized pulmonary hypercapnia can be produced by placing a small plastic ring chamber on an exposed lung surface of anesthetized bullfrogs and by introducing hypercapnic gas mixtures in it (Koyama and Horimoto, 1982). An introduction of 10% CO2 into the space formed by the ring chamber and the lung surface caused a reduction in the mean flow velocity in both arterioles and capillaries. A decrement in arteriolar diameter was observed at the same time. These results suggested a vasoconstriction of arterioles exposed to the hypercapnia. However, it remained unknown whether the reduction in capillary flow was primarily induced by a direct effect of CO2 on the capillary bed or secondarily by changes in arterioles. The present study was designed to study this aspect by reducing greatly the test area on the lung surface to such a diameter that the only vessels coming in contact with the gas are lung capillaries.
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References
Barer, G.R., and McCurrie, J.R., 1969, Pulmonary responses in the cat; The effects and interrelationship of drugs, hypoxia and hypercapnia, Quart. J. Exp. Physiol., 54: 156–172.
Borst, H.G., Whittenberger, J.L., Berglund, E., and McGregor, M., 1957, Effects of unilateral hypoxia and hypercapnia on pulmonary blood flow distribution in the dog, Am. J. Physiol., 191: 446–452.
Fishman, A.P., Fritts, H.W., and Cournand, A., 1960, Effects of breathing carbon dioxide upon the pulmonary circulation, Circulation, 22: 220–225.
Horimoto, M., Koyama, T., Kikuchi, Y., Kakiuchi, Y., and Murao, M., 1981, Effect of transpulmonary pressure on blood flow velocity in pulmonary microvessels, Respir. Physiol., 43: 31–41.
Hyman, A.L., and Kadowitz, P.J., 1957, Effects of alveolar and perfusion hypoxia and hypercapnia on pulmonary vascular resistance in the lamb, J. Appl. Physiol., 228: 397–403.
Kato, M., and Staub, N.C., 1966, Response of small pulmonary arteries to unilobular hypoxia and hypercapnia, Circ. Res., 19: 426–440.
Kikuchi, Y., Horimoto, M., and Koyama, T., 1979, Reduced deformability of erythrocytes exposed to hypercapnia, Experientia, 35: 343–344.
Koyama, T., Kikuchi, Y., Horimoto, M., Kakiuchi, Y., Tsushima, N., and Nitta, J., 1981, White blood cell adhesion to endothelium and rheological behavior in microvessels of over inflated frog’s lung, Biorheol., 19: 221–228.
Koyama, T., and Horimoto, M., 1982, Pulmonary microcirculatory response to localized hypercapnia, J. Appl. Physiol., in press.
Stroud, R.C., and Rahn, H., 1953, Effect of O2 and CO2 tensions upon the resistance of pulmonary blood vessels, Am. J. Physiol., 172: 211–220.
Viles, P.H., and Shepherd, J.T., 1968, Evidence for a dilator action of carbon dioxide on the pulmonary vessels of the cat, Circ. Res., 22: 325–333.
Weibel, E.R., 1964, Morphometrics of the lung, in: “Handbook of Physiology”, Sect. 3: “Respiration”, Vol. 1, pp. 285–307, W.O. Fenn, H. Rahn, eds., Am. Physiol. Society, Washington D.C.
Weigelt, H., 1982, Die spezialisierte Endothelzelle — erregbare Zelle und mechanischer Effektor der Mikrozirkulation, Funkt. Biol. Med., 1: 53–60.
Weigelt, H., Fujii, T., Lübbers, D.W., and Hauck, G., 1981, Specialized endothelial cells in the frog mesentery — attempt of an electrophysiological characterization, Biblthca. Anat., 20: 89–93.
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© 1984 Plenum Press, New York
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Koyama, T., Horimoto, M., Kikuchi, Y. (1984). Cessation of Capillary Blood Flow Induced by Localized Application of Carbon Dioxide. In: Lübbers, D.W., Acker, H., Leniger-Follert, E., Goldstrick, T.K. (eds) Oxygen Transport to Tissue-V. Advances in Experimental Medicine and Biology, vol 169. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1188-1_58
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DOI: https://doi.org/10.1007/978-1-4684-1188-1_58
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