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Diffusion-Perfusion Relationships in Skeletal Muscle: Models and Experimental Evidence from Inert Gas Washout

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Oxygen Transport to Tissue-V

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 169))

Abstract

The aim of the present research was to study the basic gas exchange mechanisms — diffusion and perfusion — and their interaction in order to better understand O2 and CO2 exchange in muscle tissue. Instead of the respiratory gases O2 and CO2, inert gases were used because their transfer behaviour is more easily analyzed due to absence of chemical combination and of comsumption or production.

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References

  • Aukland, K., 1967, Renal medullary heat clearance in the dog, Circ. Res., 20: 194–203.

    Article  PubMed  CAS  Google Scholar 

  • Bassingthwaighte, J.B., Strandell, T., and Yipintsoi, T., 1970, Flow limited washout of diffusible solutes from the heart, in: “Benzon Symposium II: Capillary Permeability”, C. Crone, N.A. Lassen, eds., Munksgaard, Copenhagen, pp.580–585.

    Google Scholar 

  • Bazett, H.C., Love, L., Newton, M., Eisenburg, L., Day, R., and Forster, R., 1948, Temperature changes in blood flowing in arteries and veins in man, J. Appl. Physiol., 1: 3–19.

    PubMed  CAS  Google Scholar 

  • Grunewald, W.A., and Sowa, W., 1977, Capillary structures and O2 supply to tissue, Rev. Physiol. Biochem. Pharmacol., 77: 149–209.

    Article  PubMed  CAS  Google Scholar 

  • Kety, S.S., 1951, Theory and applications of the exchange of inert gas at the lungs and tissues, Pharmacol. Rev., 3: 1–41.

    PubMed  CAS  Google Scholar 

  • Kruhøffer, P., 1970, Discussion remark, in: “Benzon Symposium II: Capillary Permeability”, C. Crone, N.A. Lassen, eds., Munksgaard, Copenhagen, pp.597-598.

    Google Scholar 

  • Ohta, Y., Song, S.H., Groom, A.C., and Farhi, L.E., 1978, Is inert gas washout from tissues limited by diffusion? J. Appl. Physiol., 45: 903–9O7.

    PubMed  CAS  Google Scholar 

  • Paradise, N.F., Swayze, C.R., Shin, D.H., and Fox, I.J., 1971, Perfusion heterogeneity in skeletal muscle using tritiated water, Am. J. Physiol., 220: 1107–1115.

    PubMed  CAS  Google Scholar 

  • Pendergast, D., Cerretelli, P., Heisler, N., Marconi, C., Meyer, M., and Piiper, J., 1982, Muscle blood flow distribution in resting and exercising dog gastrocnemius, Fed. Proc., 41: 168O.

    Google Scholar 

  • Piiper, J., 1959, Durchblutung der arterio-venösen Anastomosen und Wärmeaustausch an der Hundeextremität, Pflügers Arch. Ges. Physiol., 268: 242–253.

    Article  CAS  Google Scholar 

  • Sejrsen, P., 1970, Convection and diffusion of inert gases in cutaneous,subcutaneous, and skeletal muscle tissue, in: “Benzon Symposium II: Capillary Permeability”, C. Crone, N.A. Lassen, eds., Munksgaard, Copenhagen, pp. 586–596.

    Google Scholar 

  • Sejrsen, P., and Tønnesen, K.H., 1968, Inert gas diffusion method for measurement of blood flow using saturation technique: comparison with directly measured blood flow in isolated gastrocnemius muscle of the cat, Circ. Res., 22: 679–693.

    Article  PubMed  CAS  Google Scholar 

  • Sparks, H.V., and Mohrman, D.E., 1977, Heterogeneity of flow as an explanation of the multiexponential washout of inert gas from skeletal muscle, Microvasc. Res., 13: 181–184.

    Article  Google Scholar 

  • Tønnesen, K.H., and Sejrsen, P., 1967, Inert gas diffusion method for measurement of blood flow: comparison of bolus injection to directly measured blood flow in the isolated gastrocnemius muscle, Circ. Res., 20: 552–564.

    Article  PubMed  Google Scholar 

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© 1984 Plenum Press, New York

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Piiper, J., Meyer, M. (1984). Diffusion-Perfusion Relationships in Skeletal Muscle: Models and Experimental Evidence from Inert Gas Washout. In: Lübbers, D.W., Acker, H., Leniger-Follert, E., Goldstrick, T.K. (eds) Oxygen Transport to Tissue-V. Advances in Experimental Medicine and Biology, vol 169. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1188-1_40

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  • DOI: https://doi.org/10.1007/978-1-4684-1188-1_40

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1190-4

  • Online ISBN: 978-1-4684-1188-1

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