Functional Alteration of Membrane Integrity During Global Ischemia in Perfused Working Rabbit Hearts

  • H. Rhee
  • J. Cooper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 169)


Ischemic myocardial injury is certainly reversible following an early reperfusion of the ischemic region. A prolonged ischemic insult however, produces irreversible myocardial injury leading to permanent cell death and myocardial infarction. We now have an impressive body of knowledge about the characteristics of myocardial ischemic injury and cell death in terms of cardiac biochemistry (Allison et al., 1977; Idell-Wenger and Neely, 1977; Jennings et al., 1978; Chua et al., 1979), pathophysiology (Jennings et al., 1969; Neely et al., 1973; Lucchesi et al., 1976), and histology (Jennings et al., 1975; Schaper et al., 1979).


ATPase Activity Rabbit Heart Adenosine Triphosphatase Control Heart Ouabain Binding 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • H. Rhee
    • 1
  • J. Cooper
    • 1
  1. 1.Department of PharmacologyOral Roberts University School of MedicineTulsaUSA

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