Abstract
It has been observed that blood flow to the hindlimb was maintained or even increased in proportion to cardiac output during isovolemic hemodilution of anesthetized dogs with dextran (Grupp et al., 1972; Cain and Chapler, 1978; 1981). This was true even when the decrease in total O2 transport limited whole body O2 uptake. In one study, we infused norepinephrine to increase vasoconstrictor tone. The results suggested that the reduction in viscosity prevented any measurable increase in hindlimb resistance during anemia so that blood flow could not be redistributed to areas more essential than resting skeletal muscle. In these new experiments we have used a more physiologic cardiovascular challenge, clamping of the carotid arteries, to see if lowered blood viscosity alters the response to baroreceptor stimulation. As will be shown, the buffering effect of aortic baroreceptors prevented much change in the peripheral resistance but carotid clamping did alter O2 uptake.
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References
Cain, S.M., and Chapler, C.K., 1978, O2 extraction by hindlimb versus whole dog during anemic hypoxia, J. Appl. Physiol.: Respir. Environ. Exercise Physiol., 45: 966.
Cain, S.M., and Chapler, CK., 1981, Effects of norepinephrine and α-block on O2 uptake and blood flow in dog hindlimb, J. Appl. Physiol.: Respir. Environ. Exercise Physiol., 51: 1245.
Carswell, F., Hainsworth, R., and Ledsome, J.R., 1968, The effects of varying pressures in the aortic arch on limb resistance and heart rate, J. Physiol. (London), 196: 38P.
Chapler, C.K., and Cain, S.M., 1981, Blood flow and O2 uptake in dog hindlimb with anemia, norepinephrine, and propranolol, J. Appl. Physiol.: Respir. Environ. Exercise Physiol., 51: 565.
Donald, D.E., and Edis, A.J., 1971, Comparison of aortic and carotid baroreflexes in the dog, J. Physiol. (London), 215: 521.
Fan, F.-C., Chen, R.Y.Z., Schuessler, G.B., and Chien, S., 1980, Effects of hematocrit variations on regional hemodynamics and oxygen transport in the dog, Am. J. Physiol., 238 (Heart Circ. Physiol., 7): H545.
Grupp, I., Grupp, G., Holmes, J.C., and Fowler, N.O., 1972, Regional blood flow in anemia, J. Appl. Physiol., 33: 15.
Restorff, W. v., Höfling, B., Holtz, J., and Bassenge, E., 1975, Effect of increased blood fluidity through hemodilution on coronary circulation at rest and during exercise in dogs, Pflügers Arch., 357: 15.
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© 1984 Plenum Press, New York
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Cain, S.M., Chapler, C.K. (1984). Cardiovascular and Metabolic Responses to Carotid Clamping in Anemic Dogs. In: Lübbers, D.W., Acker, H., Leniger-Follert, E., Goldstrick, T.K. (eds) Oxygen Transport to Tissue-V. Advances in Experimental Medicine and Biology, vol 169. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1188-1_33
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DOI: https://doi.org/10.1007/978-1-4684-1188-1_33
Publisher Name: Springer, Boston, MA
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