Metabolic Rate and Microcirculation

  • W. Kuschinksky
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 169)


The first hypothesis about the dependency of microcirculation on the metabolic rate of the corresponding tissue was put forward more than a hundred years ago (Roy and Brown, 1879; Gaskell, 1880). “It is surely worth while to see whether it is not possible that the chemical changes going on in the organ itself may not directly bring about a dilation of the blood vessels of that organ, and so, without the intervention of the nervous system, regulate its own blood supply according to its own needs” (Gaskell, 1880). This hypothesis seemed reasonable, since this mechanism allows an adjustment of the blood flow to the actual demand of the tissue. This means an economical distribution of blood flow resulting in a low heart work and energy consumption. It also means a linkage between the blood flow and that parameter, which should be its final determinant, i.e. the metabolic rate of the tissue.


Cerebral Blood Flow Glucose Utilization Regional Cerebral Blood Flow Local Blood Flow Local Cerebral Blood Flow 
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© Plenum Press, New York 1984

Authors and Affiliations

  • W. Kuschinksky
    • 1
  1. 1.Department of PhysiologyUniversity of MunichMünchen 2Germany

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