Effect of DMSO and Barbiturates on Brain Oxygen Distribution
Brain oxygen distribution in the anesthetized cat’s brain was determined using oxygen ultramicroelectrodes. The animals were anesthetized using Ketalar. Vein, artery and tracheal cannulation were performed. Oxygen distribution was expressed in histogram fashion for brain cortex, white matter and nucleus caudatus. The average Pto2 distribution was higher in cortex and nucleus caudatus than in the white matter. There was no difference between right or left side of the brain.
Three different groups of 12 cats each were experimented upon. Group I was control, anesthesia only. Group II received Thiopental, 30 mg/kg bolus followed by 30 mg/kg the second and third hours to a total of 90 mg/kg. Group III received DMSO 2 mg/kg, in addition to the procedures of Group II.
There was no difference in the histograms for cortex, white matter or nucleus caudatus between groups I and II. There was, however, a significant increase in Pto2 in Group III, especially at the level of the nucleus caudatus.