Regulation of Microflow in the Cat Brain During Insulin Induced Hypoglycemia
It is well established that severe hypoglycemia is accompanied by changes in cerebral functional activity and by a decrease in the cerebral metabolism of glucose. The results published on cerebral blood flow (CBF) during hypoglycemia are, however, controversial. Whereas most authors reported constant CBF, Norberg and Siesjö (1976) demonstrated in rats that CBF increased significantly both when the EEG showed a pattern of slow waves and polyspikes and when electrical activity ceased.
KeywordsCerebral Blood Flow Brain Cortex Severe Hypoglycemia Measuring Electrode Insulin Induce Hypoglycemia
Unable to display preview. Download preview PDF.
- Astrup, J., Heuser, D., Lassen, N.A., Nilsson, B., Norberg, K., and Siesjö, B.K., 1978, Evidence against H+ and K+ as main factors for the control of cerebral blood flow: a microelec-trode study, in: “Cerebral Vascular Smooth Muscle and its Control”, Ciba Foundation Symposium 56 (new series), Elsevier/ Excerpta Medica/North Holland, Amsterdam, Oxford, New York.Google Scholar
- Gronczewski, J., and Leniger-Follert, E., 1982, Relationship between microflow, local tissue Po2 and extracellular activities of potassium and hydrogen ions in the cat during intra-arterial infusion of ammonium acetate, this volume.Google Scholar
- Kessler, M., Höper, J., and Simon, W., 1974, Methodology and application of multiple ion-selective surface electrode (pH, pK, pNa, pCa, pCl) for tissue measurements, Fed. Proc, 33: 279.Google Scholar
- Saito, Y., Baumgärtl, H., and Lübbers, D.W., 1976, The RF-sputtering technique as a method for manufacturing needle-shaped pH-micro-electrodes, in: “Ion and Enzyme Electrodes in Biology and Medicine”, M. Kessler, L.C. Clark Jr., D.W. Lübbers, I.A. Silver, eds., Urban & Schwarzenberg, München-Berlin-Wien, pp. 103–109.Google Scholar