Oxygen Supply to the Brain Cortex in SHR and Normotensive Rats
It is postulated that there is a structural adaptation of the brain blood vessels to high blood pressure and that therefore spontaneously hypertensive stroke-resistant rats (SHR-SR) are less prone to develop blood-brain barrier (BBB) disturbances than strokeprone rats (SHR-SP). As previously reported there is evidence that also in SHR-SR the early stage of hypertension is accompanied by very early signs of BBB disorder such as dislocation of ATPase and CTPase inside the endothelial cytoplasm of brain capillaries. In the well-established phase of hypertension further changes such as an increased number of empty pinocytic vesicles or floculent dense material in the astrocyte processes were reported (Skolasinska et al., 1981).
KeywordsOxygen Supply Mean Arterial Blood Pressure Brain Cortex Scan Electron Microscopic Examination Brain Capillary
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