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Oxygen Supply to the Brain Cortex in SHR and Normotensive Rats

  • K. Skolasinska
  • H. Günther
  • J. Höper
  • R. Funk
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 169)

Abstract

It is postulated that there is a structural adaptation of the brain blood vessels to high blood pressure and that therefore spontaneously hypertensive stroke-resistant rats (SHR-SR) are less prone to develop blood-brain barrier (BBB) disturbances than strokeprone rats (SHR-SP). As previously reported there is evidence that also in SHR-SR the early stage of hypertension is accompanied by very early signs of BBB disorder such as dislocation of ATPase and CTPase inside the endothelial cytoplasm of brain capillaries. In the well-established phase of hypertension further changes such as an increased number of empty pinocytic vesicles or floculent dense material in the astrocyte processes were reported (Skolasinska et al., 1981).

Keywords

Oxygen Supply Mean Arterial Blood Pressure Brain Cortex Scan Electron Microscopic Examination Brain Capillary 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • K. Skolasinska
    • 1
  • H. Günther
    • 1
  • J. Höper
    • 1
  • R. Funk
    • 2
  1. 1.Institut für Physiologie und KardiologieUniversität Erlangen-NürnbergErlangenGermany
  2. 2.Institut für AnatomieUniversität Erlangen-NürnbergErlangenGermany

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