Muscle O2 Gradients from Hemoglobin to Cytochrome: New Concepts, New Complexities

  • C. R. Honig
  • T. E. J. Gayeski
  • W. Federspiel
  • A. ClarkJr.
  • P. Clark
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 169)


The purpose of this paper is to reappraise the sequential barriers to O2 transport from red cells to mitochondria in light of a more accurate model of intracapillary O2 transport, and measurements of myoglobin (Mb) saturation in subcellular volumes. We find that transcapillary gradients are larger and tissue gradients smaller than predicted by existing models of O2 diffusion. During exercise the principal “resistance” to O2 transport resides in the capillary and extracellular space; the limiting variables are rate of O2 release and red cell transit time. Mb plays a major role in overcoming “resistance” at the capillary by buffering Po2 well below capillary Po2 (Pcapo2). These findings are incompatible with classical concepts of O2 delivery to red muscle. Alternatives to Kroghian tinking are proposed.


Transit Time Resistance Layer Functional Capillary Density Capillary Transport PTo2 Approach 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • C. R. Honig
    • 1
  • T. E. J. Gayeski
    • 1
  • W. Federspiel
    • 2
  • A. ClarkJr.
    • 2
  • P. Clark
    • 3
  1. 1.School of Medicine and DentistryThe University of RochesterUSA
  2. 2.College of Engineering and Applied ScienceRochesterUSA
  3. 3.Rochester Institute of TechnologyUSA

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