Focal Epicerebral Ischemia: Post-Ischemic Tissue Oxygenation with and without Recirculation
According to statistical analyses of stroke cases in intensive care units, about 70% of cerebrovascular accidents are the results of vascular occlusive diseases of various origins (mainly embolic or thrombotic) (Hachinski and Norris, 1981). The majority of brain infarcts occur in the territory of the middle cerebral artery (MCA), the pathological consequences being found in the insular cortex and basal ganglia. Whereas it is commonly accepted that the primary ischemic focus is irreversibly damaged, increasing interest is being devoted to the surrounding tissue, which is still viable. In fact, maintaining the collateral circulation should be of benefit to the infarct area and restrict the extension of ischemia into adjoining tissue.
KeywordsMiddle Cerebral Artery Infarcted Area Cortical Tissue Brain Infarct Focal Ischemia
Unable to display preview. Download preview PDF.
- Blöink, M., Hossmann, V., and Hossmann, K.A., 1980, Treatment of experimental infarcts following middle cerebral artery occlusion in cats, in; “Circulation Cérébrale”, Proc. Congrès International de Circulation Cérébrale, 1979, A. Bès, C. Géraud, eds., Toulouse.Google Scholar
- Cahn, R., Poncin, J.F., and Pawelec, C., 1980, Brain cortical Po2, EEG activity, cerebral (A-V) lactate and ultrastructural changes in temporary middle cerebral artery occlusion in chloralose anaesthetized mongrel dogs, in: “Pathophysiology and Pharmacotherapy of Cerebrovascular Disorders”, A. Betz, J. Grote, D. Heuser, R. Wüllenweber, eds., Witzstrock, Baden-Baden, p. 187.Google Scholar
- Hachinski, V., and Norris, J.W., 1981, Intensive care of stroke, in: “Drugs and Methods in CVD”, Pergamon Press, Paris, p. 375.Google Scholar
- Ingvar, M.C., Feustel, P.J., Brenneman, L., and Severinghaus, J.W., 1980, Local cerebral blood flow and oxygen availability measured with the same 25 micron electrodes in cat cortex before and during middle cerebral artery ligation at altered Pco2 levels, in: “Cerebral Blood Flow and Metabolism”, F. Gotoh, H. Nagai, Y. Tazaki, eds., Munksgaard, Copenhagen, pp. 5–7.Google Scholar
- Ravvin, L.J., Feindel, W., Yamamoto, Y.L., and Hodge, C.P., 1977, Epicerebral arterial occlusion in the dog, in: “Cerebral Function, Metabolism and Circulation”, D.H. Ingvar, N.A. Lassen, eds., Munksgaard, Copenhagen, p. 363.Google Scholar
- Tamura, A., and Teasdale, G., 1980, Effects of perivascular micro-application of Nifedipine on cat pial arteriolar and venular caliber, in: “Pathophysiology and Pharmacotherapy of Cerebrovascular Disorders”, E. Betz, J. Grote, D. Heuser, R. Wüllen-weber, eds., Witzstrock, Baden-Baden, p. 19.Google Scholar
- Theodore, D., and Abraham, J., 1980, A sequentious study of capillaries in the infarcted area of primate brain, Ind. J. Med. Res., 71: 821–828.Google Scholar