Focal Epicerebral Ischemia: Post-Ischemic Tissue Oxygenation with and without Recirculation

  • N. Wiernsperger
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 169)


According to statistical analyses of stroke cases in intensive care units, about 70% of cerebrovascular accidents are the results of vascular occlusive diseases of various origins (mainly embolic or thrombotic) (Hachinski and Norris, 1981). The majority of brain infarcts occur in the territory of the middle cerebral artery (MCA), the pathological consequences being found in the insular cortex and basal ganglia. Whereas it is commonly accepted that the primary ischemic focus is irreversibly damaged, increasing interest is being devoted to the surrounding tissue, which is still viable. In fact, maintaining the collateral circulation should be of benefit to the infarct area and restrict the extension of ischemia into adjoining tissue.


Middle Cerebral Artery Infarcted Area Cortical Tissue Brain Infarct Focal Ischemia 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • N. Wiernsperger
    • 1
  1. 1.Sandoz Ltd.Preclinical ResearchBasleSwitzerland

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