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Focal Epicerebral Ischemia: Post-Ischemic Tissue Oxygenation with and without Recirculation

  • N. Wiernsperger
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 169)

Abstract

According to statistical analyses of stroke cases in intensive care units, about 70% of cerebrovascular accidents are the results of vascular occlusive diseases of various origins (mainly embolic or thrombotic) (Hachinski and Norris, 1981). The majority of brain infarcts occur in the territory of the middle cerebral artery (MCA), the pathological consequences being found in the insular cortex and basal ganglia. Whereas it is commonly accepted that the primary ischemic focus is irreversibly damaged, increasing interest is being devoted to the surrounding tissue, which is still viable. In fact, maintaining the collateral circulation should be of benefit to the infarct area and restrict the extension of ischemia into adjoining tissue.

Keywords

Middle Cerebral Artery Infarcted Area Cortical Tissue Brain Infarct Focal Ischemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Blöink, M., Hossmann, V., and Hossmann, K.A., 1980, Treatment of experimental infarcts following middle cerebral artery occlusion in cats, in; “Circulation Cérébrale”, Proc. Congrès International de Circulation Cérébrale, 1979, A. Bès, C. Géraud, eds., Toulouse.Google Scholar
  2. Bremer, A., West, C.R., and Yamada, K., 1979, Alterations in cortical oxygen tension during the development of ischemic cerebral edema in primates, Neurosurgery, 4: 233.PubMedCrossRefGoogle Scholar
  3. Cahn, R., Poncin, J.F., and Pawelec, C., 1980, Brain cortical Po2, EEG activity, cerebral (A-V) lactate and ultrastructural changes in temporary middle cerebral artery occlusion in chloralose anaesthetized mongrel dogs, in: “Pathophysiology and Pharmacotherapy of Cerebrovascular Disorders”, A. Betz, J. Grote, D. Heuser, R. Wüllenweber, eds., Witzstrock, Baden-Baden, p. 187.Google Scholar
  4. Crockard, H.A., Symon, L., Branston, N.M., and Juhasz, J., 1976, Changes in regional cortical tissue oxygen tension and cerebral blood flow during temporary middle cerebral artery occlusion in baboons, J. Neurol. Sci., 27: 29.PubMedCrossRefGoogle Scholar
  5. Crowell, R.M., and Olsson, Y., 1972, Impaired microvascular filling after focal cerebral ischemia in the monkey. Modification by treatment, Neurology, 22: 500.PubMedCrossRefGoogle Scholar
  6. Hachinski, V., and Norris, J.W., 1981, Intensive care of stroke, in: “Drugs and Methods in CVD”, Pergamon Press, Paris, p. 375.Google Scholar
  7. Harris, R.J., Symon, L., Branston, N.M., and Bayhan, M., 1981, Changes in extracellular calcium activity in cerebral ischemia, J. Cereb. Blood Flow Metab., 1: 203.PubMedCrossRefGoogle Scholar
  8. Ingvar, M.C., Feustel, P.J., Brenneman, L., and Severinghaus, J.W., 1980, Local cerebral blood flow and oxygen availability measured with the same 25 micron electrodes in cat cortex before and during middle cerebral artery ligation at altered Pco2 levels, in: “Cerebral Blood Flow and Metabolism”, F. Gotoh, H. Nagai, Y. Tazaki, eds., Munksgaard, Copenhagen, pp. 5–7.Google Scholar
  9. Kamijyo, Y., Garcia, J.H., and Cooper, J., 1977, Temporary regional cerebral ischemia in the cat, J. Neuropathol. Exp. Neurol., 36: 337.CrossRefGoogle Scholar
  10. Little, J.R., Cook, A., Cook, S.A., and McIntyre, W.J., 1981, Micro-circulatory obstruction in focal cerebral ischemia: albumin and erythrocyte transit, Stroke, 12: 218.PubMedCrossRefGoogle Scholar
  11. Little, J.R., and O’Shaughnessy, D., 1979, Treatment of acute focal ischemia with continuous CSF drainage and mannitol, Stroke, 10: 446.PubMedCrossRefGoogle Scholar
  12. Peerless, S.J., Ishikawa, R., Hunter, I.G., and Peerless, M.J., 1981, Protective effect of Fluosol-DA in acute cerebral ischemia, Stroke, 12: 558.PubMedCrossRefGoogle Scholar
  13. Ravvin, L.J., Feindel, W., Yamamoto, Y.L., and Hodge, C.P., 1977, Epicerebral arterial occlusion in the dog, in: “Cerebral Function, Metabolism and Circulation”, D.H. Ingvar, N.A. Lassen, eds., Munksgaard, Copenhagen, p. 363.Google Scholar
  14. Schuier, F.J., and Hossmann, K.A., 1980, Experimental brain infarcts in cats. II. Ischemic brain edema, Stroke, 11: 593.PubMedCrossRefGoogle Scholar
  15. Sundt, T.M., and Waltz, A.G., 1967, Hemodilution and anticoagulation. Effects on the microvasculature and microcirculation of the cerebral cortex after arterial occlusion, Neurology, 17: 230.PubMedCrossRefGoogle Scholar
  16. Tamura, A., and Teasdale, G., 1980, Effects of perivascular micro-application of Nifedipine on cat pial arteriolar and venular caliber, in: “Pathophysiology and Pharmacotherapy of Cerebrovascular Disorders”, E. Betz, J. Grote, D. Heuser, R. Wüllen-weber, eds., Witzstrock, Baden-Baden, p. 19.Google Scholar
  17. Theodore, D., and Abraham, J., 1980, A sequentious study of capillaries in the infarcted area of primate brain, Ind. J. Med. Res., 71: 821–828.Google Scholar
  18. Wiernsperger, N., and Gygax, P., 1981, Determination of tissular Po2 in brain microvascular research, Eur. Neurol, 20: 200.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • N. Wiernsperger
    • 1
  1. 1.Sandoz Ltd.Preclinical ResearchBasleSwitzerland

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