Response of Gerbil Cerebral Unit Activity to Slowly Declining Tissue Po2
Within the central nervous system, regional differences may exist in oxygen tension due to the variation in such factors as blood flow, capillary density, and rates of tissue respiration. Also, cells located near the venous portion of a capillary should be exposed to a lower oxygen tension than cells at the arterial end as suggested by modeling based on the Krogh cylinder (Krogh, 1919). Such Po2 differences, in fact, have been demonstrated experimentally (Silver, 1965; Metzger and Heuber, 1977). During an ischemic or hypoxic insult, certain cells may be the first casualties in that the Po2 may reach zero more quickly for those cells normally existing in low Po2 areas.
KeywordsSpike Frequency Lower Oxygen Tension Tissue Respiration Hypoxic Insult Cerebral Grey Matter
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