Abstract
Within the central nervous system, regional differences may exist in oxygen tension due to the variation in such factors as blood flow, capillary density, and rates of tissue respiration. Also, cells located near the venous portion of a capillary should be exposed to a lower oxygen tension than cells at the arterial end as suggested by modeling based on the Krogh cylinder (Krogh, 1919). Such Po2 differences, in fact, have been demonstrated experimentally (Silver, 1965; Metzger and Heuber, 1977). During an ischemic or hypoxic insult, certain cells may be the first casualties in that the Po2 may reach zero more quickly for those cells normally existing in low Po2 areas.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Erdmann, W., Kunke, St., and Krell, W., 1973, Tissue Po2 and cell function — An experimental study with multimicroelectrodes in the rat brain, in.: “Oxygen Supply”, M. Kessler, D.F. Bruley, L.C. Clark, D.W. Lübbers, I.A. Silver, J. Strauss, eds., University Park Press, Baltimore.
Krogh, A., 1919, The number and distribution of capillaries in muscles with the calculation of the oxygen pressure head necessary for supplying the tissue, J. Physiol. (London), 52: 409–415.
Kunke, St., Erdmann, W., and Metzger, H., 1972, A new method for simultaneous Po2 and action potential measurements in microareas of tissue, J. Appl. Physiol., 32: 436–438.
Longmuir, I., and Pashko, L., 1977, The role of facilitated diffusion of oxygen in tissue hypoxia, Int. J. Biometeor., 21: 179–187.
Metzger, H., and Heuber, S., 1977, Local oxygen tension and spike activity of the cerebral grey matter of the rat and its response to short intervals of O2 deficiency or CO2 excess, Pflügers Arch., 370: 201–209.
Silver, I., 1965, Some observations in the cerebral cortex with an ultramicro, membrane-covered, oxygen electrode, Med. Electron. Biol. Engn., 3: 377–387.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Plenum Press, New York
About this chapter
Cite this chapter
Martin, R.M., Halsey, J.H. (1984). Response of Gerbil Cerebral Unit Activity to Slowly Declining Tissue Po2 . In: Lübbers, D.W., Acker, H., Leniger-Follert, E., Goldstrick, T.K. (eds) Oxygen Transport to Tissue-V. Advances in Experimental Medicine and Biology, vol 169. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1188-1_16
Download citation
DOI: https://doi.org/10.1007/978-1-4684-1188-1_16
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-1190-4
Online ISBN: 978-1-4684-1188-1
eBook Packages: Springer Book Archive