Relations Between Po2 and Neuronal Activity in Hippocampal Slices

  • D. Bingmann
  • G. Kolde
  • H. G. Lipinski
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 169)


It is well known that the oxygen supply of the brain is characterized by typical profiles of Po2 (PtO2) in the tissue (Lübbers, 1969) and that the function of the CNS widely depends on an adequate distribution of PtO2. Hyperoxic PtO2 values, on the one hand, can induce seizures (cf. Bean, 1945; Lehmenkühler et al., 1978). During hypoxia, on the other hand, Speckmann and Caspers (1974) observed a depolarization of neurons in the spinal cord and in the brain cortex which was accompanied by a transient rise of neuronal activity until spike generation was blocked. Different mechanisms may contribute to this dependency of neuronal functions on Po2. (i) Yamamoto and Kurokawa (1970) described that hypoxia modified the energy state of neurons in vitro, (ii) Vyskocil et al. (1972), Morris (1974), Silver (1977) and Lehmenkühler et al. (1981) have shown that the oxygen deficiency alters the ionic milieu of the extracellular space which may be due to neuronal and/or glial dysfunctions as well as to changes of transport rates of ions via microcirculation. (iii) Finally, synaptic inputs e.g. from chemoreceptors can alter the neuronal activity. As a whole, during changes of Po2 neurons in vivo are affected by a great number of factors which can hardly be controlled simultaneously.


Neuronal Activity Hippocampal Slice Rest Membrane Potential Membrane Resistance Potassium Activity 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • D. Bingmann
    • 1
  • G. Kolde
    • 2
  • H. G. Lipinski
    • 1
  1. 1.Institute of PhysiologyUniversity of MünsterGermany
  2. 2.Institute of CytobiologyUniversity of MünsterGermany

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