Abstract
Facilitated diffusion of a permeant is transport with a rate faster than that according to the diffusive conditions of the permeant. This enhancement may be effected by a molecular carrier reversibly reacting with the permeant. The kind of facilitated transport where the permeant is transported both in free form and combined with a carrier (as pertains to oxygen) is called “carrier-mediated transport” (Schultz et al., 1974). Such a carrier shows saturation behavior due to the finite concentration of carrier and can be inhibited by molecules structurally similar to and thus competing with the carried species. The total transport is the sum of the two components, free diffusion and the permeant and the diffusion of the carrier loaded with the permeant. These two movements obey their respective concentration gradients which are not independent but related by the rates of chemical reactions between permeant and carrier. Carrier-mediated transport therefore belongs to the class of reaction-enhanced transport and is analyzed as a problem of diffusion coupled with reversible chemical reactions. After the establishment of facilitation of O2 diffusion in the presence of hemoglobin or myoglobin by Klug et al. (1956), Wittenberg (1959) and Scholander (1960), much experimental and theoretical work during the past two decades has clarified the mechanism and the conditions of this phenomenon.
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Kreuzer, F., Hoofd, L. (1984). Facilitated Diffusion of Oxygen: Possible Significance in Blood and Muscle. In: Lübbers, D.W., Acker, H., Leniger-Follert, E., Goldstrick, T.K. (eds) Oxygen Transport to Tissue-V. Advances in Experimental Medicine and Biology, vol 169. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1188-1_1
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