Abstract
The speed of sound in mammalian (canine) tissue was measured as a function of temperature to determine whether these measurements have the stability, repeatability and freedom from artifact to qualify speed as a scan parameter in a CT ultrasounc thermal mapping system. This system would provide thermal dosimetry for the treatment of cancer by hyperthermia; a modality which is receiving acceptance by the medical community, but has been hampered by inadequate dosimetry. Measurements were made of the speed of sound as a function of temperature using a 5 MHz pulse transmission velocimeter on a number of canine tissues both in vitro and in vivo. Measurements were also made in vivo on extracorporeal blood and on a number of malignant tumors. Biochemical fractions were taken from the insonified volumes, and speed fit to a multiple regression model involving these fractions and temperature. Conclusions are: (1) the speed of sound as a function of temperature can be measured in vivo with stability and freedom from artifact, (2) relatively large variation from tissue to tissue makes speed an improbable thermal scan parameter; however, (3) the temperature coefficient of ultrasound may have possible use in thermal dosimetry.
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Nasoni, R.L., Bowen, T., Dewhirst, M.W., Roth, H.B., Premovich, R. (1982). The Speed of Sound as a Thermal Image CT Scan Parameter. In: Powers, J.P. (eds) Acoustical Imaging. Acoustical Imaging, vol 11. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1137-9_37
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DOI: https://doi.org/10.1007/978-1-4684-1137-9_37
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