Abstract
It is commonly accepted that the opiate drugs and the enkephalins and endorphins exert their effects by binding to stereospecific receptors on membranes. There appear to be several types of receptor and four main varieties have so far been claimed, κ, σ, δ, and µ (Martin et al., 1976; Lord et al., 1977). Relatively little attention has as yet been paid to what happens after receptor activation. It is usually assumed, although often not explicitly stated, that this activation involves modulation of ion fluxes across the membrane. However, some work suggests that cyclic AMP and prostaglandins may also be involved at the second-messenger level.
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Horrobin, D.F. (1982). Possible Roles of Prostaglandins in Mediating Opioid Actions. In: Shah, N.S., Donald, A.G. (eds) Endorphins and Opiate Antagonists in Psychiatric Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1119-5_5
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