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A Role for Opioid Peptides in Attentional Functioning Clinical Implications

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Endorphins and Opiate Antagonists in Psychiatric Research

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Abstract

The discovery of endogenous opiatelike peptides brought to neuroscience research new techniques for studying behavior and the hope of increasing the responsiveness of some aspects of psychopathology to pharmacological manipulation. In addition, the similarity of opiate effects to the symptoms of several behavioral disorders raises the possibility that these disorders are associated with abnormalities in endorphin production, metabolism, or receptor function. The 20-year search for a role of catecholamines in affective illness and schizophrenia has been recapitulated in 5 short years of endorphin research.

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References

  • Belluzzi, J. D., and Stein, L., 1977, Enkephalin may mediate euphoria and drive-reduction reward, Nature (London) 266: 556.

    Article  Google Scholar 

  • Buchsbaum, M. S., 1977, The middle evoked response components and schizophrenia, Schizophrenia Bull. 3: 93.

    Google Scholar 

  • Buchsbaum, M. S., Davis, G. C., and Bunney, W. E., Jr., 1977, Naloxone alteration of pain perception and somatosensory evoked potentials in normal subjects, Nature (London) 270: 620.

    Article  Google Scholar 

  • Buchsbaum, M. S., Davis, G. C., Goodwin, F. K., Murphy, D. L., and Post, R. M., 1980, Psychophysical pain judgments and somatosensory evoked potentials in patients with affective illness and in normal adults, in: Clinical Neurophysiological Aspects of Psychopathological Conditions ( C. Perris, L. von Knörring, and D. Kemali, eds.), pp. 63–72, Karger, Basel.

    Google Scholar 

  • Davis, G. C., Bunney, W. E., Jr., DeFraites, E. G., Kleinman, J. E., van Kammen, D. P., Post, R. M., and Wyatt, R. J., 1977, Intravenous naloxone administration in schizophrenia and affective illness, Science 197: 74.

    Article  Google Scholar 

  • Davis, G. C., Buchsbaum, M. S., and Bunney, W. E., Jr., 1979a, Analgesia to painful stimuli in affective illness, Am. J. Psychiatry 136: 1148.

    Google Scholar 

  • Davis, G. C., Buchsbaum, M. S., and Bunney, W. E., Jr., 1979b, Research in endorphins and schizophrenia, Schizophrenia Bull. 5: 244.

    Google Scholar 

  • Davis, G. C., Bunney, W. E., Jr., Buchsbaum, M. S., DeFraites, E. G., Duncan, W., Gillin, J. C., van Kammen, D. P., Kleinman, J., Murphy, D. L. Post, R. M., Reus, V., and Wyatt, R. J., 1979c, Use of narcotic antagonists to study the role of endorphins in normal and psychiatric patients, in: Endorphins in Mental Health Research ( E. Usdin, W. E. Bunney, Jr., and N. S. Kline, eds.), pp. 393–406, Oxford University Press, London.

    Google Scholar 

  • Davis, G. C., Buchsbaum, M. S., van Kammen, D. P., and Bunney, W. E., Jr., 1979d, Analgesia to pain stimuli in schizophrenics and its reversal by naltrexone, Psychiatry Res. 1: 61.

    Article  Google Scholar 

  • Davis, G. C., Buchsbaum, M. S., and Bunney, W. E., Jr., 1980, Alteration of evoked potentials link research in attention dysfunction to peptide responsive symptoms of schizophrenia, in: Neural Peptides and Neuronal Communications (E. Costa and M. Trabucchi, eds.),pp. 473–478, Raven Press, New York.

    Google Scholar 

  • Desmedt, J. E., and Robertson, D., 1977, Differential enhancement of early and late components of the cerebral somatosensory evoked potentials during forced-paced cognitive tasks in man, J. Psychol. 271: 761.

    Google Scholar 

  • de Wied, D., Bohus, B., van Ree, J. M., and Urban, I., 1978a, Behavioral and electrophysiological effects of peptides related to lipotropin (â-LPH), J. Pharmacol. Exp. Ther. 204: 570.

    Google Scholar 

  • de Wied, D., Kovacs, G. L., Bohus, B., van Ree, J. M., and Greven, H. M., 1978b, Neuroleptic activity of th neuropeptide â-LPH62–77 ([des-Tyr1]-γ-endorphin; DTyE), Eur. J. Pharmacol. 49: 427.

    Article  Google Scholar 

  • Emrich, H. M., Cording, C., Pirée, S., Kölling, A., von Zerssen, D., and Herz, A., 1977, Indication of an antipsychotic action of the opiate antagonist naloxone, Pharmakopsychiatr. Neuro-Psychopharmakol. 10: 265.

    Google Scholar 

  • Buchsbaum, M. S., 1977, The middle evoked response components and schizophrenia, Schizophrenia Bull. 3: 93.

    Google Scholar 

  • Gessa, G. L., Paglietti, E., and Quarantotti, B. P., 1979, Induction of copulatory behavior in sexually inactive rats by naloxone, Science 204: 203.

    Article  Google Scholar 

  • Gispen, W. H., Wiegant, V. M., Bradbury, A. F., Holme, E. C., Smyth, D. G., Snell, C. R., and de Wied, D., 1976, Induction of excessive grooming in the rat by fragments of lipotropin, Nature (London) 264: 796

    Article  Google Scholar 

  • Gritz, E. R., Shiffman, S. M., Jarvik, M. E., Schlesinger, J., and Charuvastra, V. C., 1976, Naltrexone: Physiological and psychological effects of single doses, Clin. Pharmacol. Ther. 19: 773.

    Google Scholar 

  • Gunne, L. M., Lindström, L., and Terenius, L., 1977, Naloxone-induced reversal of schizophrenic hallucinations, J. Neural Transm. 40: 13.

    Article  Google Scholar 

  • Hall, K. R. L., and Stride, E., 1954, The varying response to pain in psychiatric disorders: A study in abnormal psychology, Br. J. Med. Psychol. 27: 48.

    Article  Google Scholar 

  • Hillyard, S. A., Picton, T. W., and Regan, D., 1978, Sensation, perception and attention: Analysis using ERPs, in Event-Related Brain Potentials in Man ( E. Callaway, P. Tueting, and S. H. Koslow, eds.), pp. 223–320, Academic Press, New York.

    Google Scholar 

  • Holtzman, S. G., 1975, Effects of narcotic antagonists on fluid intake in the rat, Life Sci. 16: 1456.

    Article  Google Scholar 

  • Janowsky, D., Judd, L., Huey, L., Roitman, N., Parker, D., and Segal, D., 1978, Naloxone effects on manic symptoms and growth hormone levels, Lancet 2: 320.

    Article  Google Scholar 

  • Kastin, A. J., Miller, L. H., Gonzalez-Barcena, D., Hawley, W. D., Dyster-Aas, K., Schally, A. V., and Velasco de Panra, M. L., 1971, Psychophysiologic correlates of MSH activity in man, Physiol. Behay. 7: 893.

    Article  Google Scholar 

  • Kyriakides, M., Silverstone, T., Jeffcoate, W., and Laurence, B., 1980, Effect of naloxone on hyperphagia in Prader—Willi syndrome, Lancet 1: 876.

    Article  Google Scholar 

  • Lipinski, J., Meyer, R., Kornetsky, C., and Cohen, B. M., 1979, Naloxone in schizophrenia: Negative result Lancet 1: 1292.

    Article  Google Scholar 

  • McCloy, J., and McCloy, R. F., 1979, Enkephalins, hunger, and obesity, Lancet 2: 156.

    Article  Google Scholar 

  • Malmo, R. B., and Shagass, C., 1949, Physiologic studies of reaction to stress in anxiety and early schizophrenia, Psychosom. Med. 11: 9.

    Google Scholar 

  • Malmo, R. B., Shagass, C., and Smith, A. A., 1951, Responsiveness in chronic schizophrenia, J. Pers. 19: 359.

    Article  Google Scholar 

  • Marchand, W. E., 1955, Occurrence of painless myocardial infarction in psychotic patients, N. Engl. J. Med. 253: 51.

    Article  Google Scholar 

  • Marchand, W. E., Sarota, B., Marble, H. C., Leay, T. M., Burbank, C. B., and Bellinger, M. J., 1969, Occurrence of painless acute surgical disorders in psychotic patients, N. Engl. J. Med. 206: 580.

    Google Scholar 

  • Mednick, S. A., 1974, Breakdown in individuals at high risk for schizophrenia: Possible predispositional perinatal factors, in: Genetics, Environment and Psychopathology ( S. A. Mednick, F. Schulsinger, J. Higgins, and B. Bell, eds.), pp. 89–102, Elsevier/NorthHolland, Amsterdam.

    Google Scholar 

  • Miller, L. H., Kastin, A. J., Sandman, C. A., Fink, M., and van Vien, W. J., 1974, Polypeptide influences in attention, memory, and anxiety in man, Pharmacol. Biochem. Behay. 2: 663.

    Article  Google Scholar 

  • Mirin, S. M., Meyer, R. E., Mendelson, J. H., and Ellingboe, J., 1980, Opiate use and sexual function, Am. J. Psychiatry 137: 909.

    Google Scholar 

  • Pradalier, A., Willer, J. C., Boureau, F., and Dry, J., 1980, Pain and Obesity, Lancet 1: 1090.

    Article  Google Scholar 

  • Sandman, C. A., George, J. M., Nolan, J. D., Van Riezen, H., and Kastin, A. J., 1975, Enhancement of attention in man with ACTH/MSH 4–10, Physiol. Behay. 15: 427.

    Google Scholar 

  • Sappington, J., 1973, Thresholds of shock-induced discomfort in process and reactive schizophrenics, Percept. Mot. Skills 37: 489.

    Article  Google Scholar 

  • Spohn, H. E., Lacoursiere, B., Thompson, K., and Coyne, L., 1977, Phenothiazine effects on psychological and psychophysiological dysfunction in chronic schizophrenies, Arch. Gen. Psychiatry 34: 633.

    Article  Google Scholar 

  • Stein, L., and Belluzzi, J. D., 1978, Brain endorphins and the sense of well-being, in The Endorphins ( E. Costa and M. Trabucchi, eds.), pp. 299–311, Raven Press, New York.

    Google Scholar 

  • Stein, L., and Belluzzi, J. D., 1979, Brain endorphins: Possible mediators of pleasurable states, in Endorphins in Mental Health Research ( E. Usdin, W. E. Bunney, Jr., and N. S. Kline, eds.), pp. 375–389, Oxford University Press, London.

    Google Scholar 

  • Terenius, L., Wahlström, A., Lindström, L. H., and Widerlöv, E., 1976, Increased CSF levels of endorphin in chronic psychosis, Neurosci. Lett. 3: 157.

    Article  Google Scholar 

  • Terenius, L., Wahlström, A., and Johansson, F., 1979, Endorphins in human cerebrospinal fluid and their measurement, in: Endorphins in Mental Health Research ( E. Usdin, W. E. Bunney, Jr., and N. S. Kline, eds.), pp. 553–560, Oxford University Press, London.

    Google Scholar 

  • Van Riezen, H., Rigter, H., and de Wied, D., 1977, Possible significance of ACTH fragments for human mental performance, Behay. Biol. 20: 311.

    Article  Google Scholar 

  • Watson, S. J., Berger, P. A., Akil, H., Mills, M. J., and Barchas, J. D., 1978, Effects of naloxone on schizophrenia: Reduction in hallucinations in a subpopulation of subjects, Science 201: 73.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Psychiatry, Case Western Reserve School of Medicine and Cleveland VAMC, Cleveland, Ohio, USA

    Glenn C. Davis

  2. Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, USA

    Monte S. Buchsbaum & William E. Bunney Jr.

Authors
  1. Glenn C. Davis
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  2. Monte S. Buchsbaum
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  3. William E. Bunney Jr.
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Editor information

Editors and Affiliations

  1. William S. Hall Psychiatric Institute, Department of Neuropsychiatry and Behavioral Sciences, Department of Pharmacology, University of South Carolina School of Medicine, Columbia, South Carolina, USA

    Nandkumar S. Shah Ph.D. (Chief of Research Services, Research Professor, Adjunct Professor) (Chief of Research Services, Research Professor, Adjunct Professor)

  2. William S. Hall Psychiatric Institute, Department of Neuropsychiatry and Behavioral Sciences, University of South Carolina School of Medicine, Columbia, South Carolina, USA

    Alexander G. Donald M.D. (Director, Professor and Chairman) (Director, Professor and Chairman)

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© 1982 Plenum Publishing Corporation

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Davis, G.C., Buchsbaum, M.S., Bunney, W.E. (1982). A Role for Opioid Peptides in Attentional Functioning Clinical Implications. In: Shah, N.S., Donald, A.G. (eds) Endorphins and Opiate Antagonists in Psychiatric Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1119-5_27

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  • DOI: https://doi.org/10.1007/978-1-4684-1119-5_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1121-8

  • Online ISBN: 978-1-4684-1119-5

  • eBook Packages: Springer Book Archive

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