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Endorphins and Opiate Antagonists in Psychiatric Research pp 375–397Cite as

Endorphins and Affective Illness

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Abstract

The discovery of specific opiate receptors (Simon et al., 1973; Pert and Snyder, 1973) and the identification of naturally occurring peptides possessing opiatelike activity (endorphins) (Hughes et al., 1975; Li and Chung, 1976; Li et al., 1976; Bradbury et al., 1976; Chrétien et al., 1976) have led to considerable research and speculation regarding the relationship of the endorphin system to psychiatric illness (Usdin et al., 1979; Verebey et al., 1978). The mood-altering and calming effects of exogenous opiates (Jaffe and Martin, 1975), the regional brain distribution of opiate receptors (Goldstein, 1976; Goldstein and Cox, 1977), and the behavioral effects of administered endorphins to rats (Bloom et al., 1976) suggested potential relationships between the endogenous opioid systems and emotional behavior. Although initial endorphin-behavioral hypotheses focused on etiologic relevance to schizophrenia (Bloom et al., 1976; Segal et al., 1977), alterations in endorphin function have been hypothesized to be reflected in disorders of mood (Byck, 1976; Belluzzi and Stein, 1977; Gold and Byck, 1978).

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Authors and Affiliations

  1. Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, USA

    David Pickar & Dieter Naber

  2. Clinical Psychobiology Branch, National Institute of Mental Health, Bethesda, Maryland, USA

    Irl Extein, Philip W. Gold, Richard Summers & Frederick K. Goodwin

  3. Summit, Fair Oaks Hospital, New Jersey, USA

    Irl Extein

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  1. David Pickar
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  6. Frederick K. Goodwin
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Editors and Affiliations

  1. William S. Hall Psychiatric Institute, Department of Neuropsychiatry and Behavioral Sciences, Department of Pharmacology, University of South Carolina School of Medicine, Columbia, South Carolina, USA

    Nandkumar S. Shah Ph.D. (Chief of Research Services, Research Professor, Adjunct Professor) (Chief of Research Services, Research Professor, Adjunct Professor)

  2. William S. Hall Psychiatric Institute, Department of Neuropsychiatry and Behavioral Sciences, University of South Carolina School of Medicine, Columbia, South Carolina, USA

    Alexander G. Donald M.D. (Director, Professor and Chairman) (Director, Professor and Chairman)

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© 1982 Plenum Publishing Corporation

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Pickar, D., Extein, I., Gold, P.W., Summers, R., Naber, D., Goodwin, F.K. (1982). Endorphins and Affective Illness. In: Shah, N.S., Donald, A.G. (eds) Endorphins and Opiate Antagonists in Psychiatric Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1119-5_22

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  • DOI: https://doi.org/10.1007/978-1-4684-1119-5_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1121-8

  • Online ISBN: 978-1-4684-1119-5

  • eBook Packages: Springer Book Archive

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