Abstract
The neuromuscular junction is the link between nerve and muscle. An action potential arriving at the nerve ending liberates a chemical transmitter substance, which diffuses across the synaptic cleft to interact with specific receptors in the postsynaptic membrane. This leads to the opening of ionic channels in this membrane. The resultant conductance increase depolarizes the muscle fiber, which in turn triggers an action potential and thereby initiates contraction (For a review article see Steinbach & Stevens (1976)).
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References
ADAMS, P.R. (1975) A study of desensitization using voltage clamp. Pfluegers Arch, ges. Physiol. 360, pp. 135–144.
ANDERSON, C.R. & STEVENS, C.F. (1973) Voltage clamp analysis of Acetylcholine produced end-plate current fluctuations at frog neuromuscular junction. J. Physiol. 235, pp. 655–691.
AXELSSON, J. & THESLEFF, S. (1959) A study of supersensitivity in denervated mammalian skeleton muscle. J. Physiol. 147, pp. 178–193.
COLQUHOUN, D. & HAWKES, A.G. (1977) Relaxation and fluctuations of membrane currents that flow through drug-operated channels. Proc. R. Soc. Lond. B 199, pp. 231–262.
DIONNE, V.E., STEINBACH, J.H., & STEVENS, C.F. (1978) An analysis of the dose-response relationship at voltage-clamped forg neuromuscular junctions. J. Physiol. 281, pp. 421–444.
DREYER, F., PEPER, J.H. & STERZ, R. (1978) Determination of dose-response curves by quantitative ionophoresis at the frog neuromuscular junction. J. Physiol. 281, pp. 395–419.
KATZ, B. & MILEDI, R. (1972) The statistical nature of the acetylcholine potential and its molecular components. J. Physiol. 224, pp. 665–669.
KATZ, B. & MILEDI, R. (1973) The characteristics of “end-plate noise” produced by different depolarizing drugs. J. Physiol. 230, pp. 707–717.
MAGLEBY, K.L. & STEVENS, C.F. (1972) A quantitative description of end-plate currents. J. Physiol. 223, pp. 705–729.
NEHER, E. & SAKMANN, B. (1976) Noise analysis of drug induced voltage clamp currents in denervated frog muscle fibers. J. Physiol. 258, pp. 705–729.
NEHER, E., SAKMANN, B. & STEINBACH, J.H. (1975) The extracellular patch clamp: A method for resolving currents through individual open channels in biological membranes. Pfluegers. Arch. 375, pp. 219–228.
SAKMANN, B., PATLAK, J. & NEHER, E. (1980) Single acetylcholine-activated channels show burst-kinetics in the presence of desensitizing agonist concentrations. Submitted.
STEINBACH, J.H. & STEVENS, C.F. (1976) Neuromuscular Transmission. In: “Frog Neurobiology, a handbook” (Llinas, R. and Precht, W. eds.) Springer-Verlag-Berlin-Heidelberg-New York, 1976, pp. 33–92.
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© 1980 Plenum Press, New York
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Neher, E. (1980). Single Channel Conductance Measurements at the Neuromuscular Junction. In: Borsellino, A., Omodeo, P., Strom, R., Vecli, A., Wanke, E. (eds) Developments in Biophysical Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1077-8_4
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DOI: https://doi.org/10.1007/978-1-4684-1077-8_4
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