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Internal pH and K+ Channel Rate Constants

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Developments in Biophysical Research

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Abstract

The effects of changing the proton content of solutions bathing excitable membranes has been the subject of many reports in the jpast. (1-7). Two main effects were commonly observed although they differed quantitatively upon changing the nerve preparation: a) a shift on the voltage axis of the parameters characterizing nerve excitability (similar to the action of divalent ions (8)), b) a variation of the steady-state maximum conductance of the open channels selective for sodium and potassium ions. A third type of effects concerns phenomena such as the voltage-dependent block of Na+-channels observed by Woodhull (9) in the node of Ranvier.

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References

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Authors and Affiliations

  1. Laboratorio di Cibernetica e Biofisica, Consiglio Nazionale delle Ricerche, 16032, Camogli, Italy

    P. L. Testa, E. Carbone & E. Wanke

Authors
  1. P. L. Testa
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  2. E. Carbone
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  3. E. Wanke
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Editor information

Editors and Affiliations

  1. University of Genoa, Genoa, Italy

    Antonio Borsellino

  2. University of Padua, Padua, Italy

    Pietro Omodeo

  3. University of Rome, Rome, Italy

    Roberto Strom

  4. University of Parma, Parma, Italy

    Arnaldo Vecli

  5. CNR Laboratory of Cybernetics and Biophysics, Camogli (Genoa), Italy

    Enzo Wanke

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© 1980 Plenum Press, New York

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Testa, P.L., Carbone, E., Wanke, E. (1980). Internal pH and K+ Channel Rate Constants. In: Borsellino, A., Omodeo, P., Strom, R., Vecli, A., Wanke, E. (eds) Developments in Biophysical Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1077-8_2

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  • DOI: https://doi.org/10.1007/978-1-4684-1077-8_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1079-2

  • Online ISBN: 978-1-4684-1077-8

  • eBook Packages: Springer Book Archive

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