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Role of a “Critical” Fatty Acid Concentration on Phospholipid Exchange and Size Enlargement of Sonicated Vesicles

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Developments in Biophysical Research
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Abstract

In recent times fatty acids were used not only as probes for the phospholipid bilayer structure, but also as inducers of important biological processes such as membrane fusion (1), membrane permeability changes (2), phospholipid exchange (3,4) and phospholipid vesicle size enlargement (3–7). These observations point out that fatty acids, having a higher concentration in heart and brain than in other tissues, may play an important role in regulating many biological functions. In the present work the role of fatty acids in phospholipid exchange and in vesicle size enlargement is investigated.

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References

  1. J. I. Howell, D. Fisher, A. H. Goodall, M. Verrinder and J. A. Lucy, Interactions of membrane phospholipids with fusogenic lipids, Biochim. Biophys. Acta 332:1–10 (1973).

    Google Scholar 

  2. R. Hori, Y. Kagimoto, K. Kamiya and K. J. luni. Effects of free fatty acids as membrane components on permeability of drugs across bilayer lipid membranes. A mechanism for intestinal absorption of acidic drugs, Biochim. Biophys. Acta 509:510–518 (1978).

    Article  Google Scholar 

  3. J. M. H. Kremer and P. H. Wiersema, Exchange and aggregation in dispersions of dimiristoyl phosphatidylcholine vesicles containing myristic acid, Biochim. Biophys. Acta 471:348–360 (1977).

    Article  Google Scholar 

  4. D. Papahadjopoulos, S. Hui, W. J. Vail and G. Poste, Studies on membrane fusion. 1. Interaction of pure phospholipid membranes and the effect of myristic acid, lysolecithin, proteins and dimethylsulfoxide, Biochim. Biophys. Acta 448:245–264 (1976).

    Article  Google Scholar 

  5. H. L. Kantor and J. H. Prestegard, Fusion of fatty acid containing lecithin vesicles, Biochemistry 14: 1790–1795 (1975).

    Article  Google Scholar 

  6. H. L. Kantor, S. Mabrey, J.H. Prestegard and J.M. Sturtevant, A calorimetric examination of stable and fusing lipid bilayer vesicles, Biochim. Biophys. Acta 466:402–410 (1977).

    Article  Google Scholar 

  7. H. L. Kantor and J. H. Prestegard, Fusion of phosphatidylcholine bilayer vesicles: role of free fatty acid, Biochemistry 17: 3592–3597 (1978).

    Article  Google Scholar 

  8. J. R. Usher, R. M. Epand and D. Papahadjopoulos, The effect of free fatty acids on the thermotropic phase transition of dimiristoylglicerophosphocholine, Chem. Phys. Lipids 22:245–253 (1978).

    Article  Google Scholar 

  9. F. Podo and J. K. Blasie, Proton magnetic relaxation studies of mixed phosphatidylcholine fatty acid and mixed phosphatidylcholine bimolecular bilayers, Biochim. Biophys. Acta 419:1–18 (1976).

    Article  Google Scholar 

  10. A.W. Eliasz, D. Chapman and D.F. Ewing, Phospholipid phase transitions. Effects of n-alcohols, n-monocarboxylic acids, phenylalkyl alcohols and quaternary ammonium compounds, Biochim. Biophys. Acta 448:220–230 (1976).

    Article  Google Scholar 

  11. A.C. Lee, Functional properties of biological membranes. A physical-chemical approach, Prog. Biophys. Molec. Biol. 29: 3–56 (1975).

    Article  Google Scholar 

  12. K. W. Butler, N. H. Tattrie and I. C. P. Smith, The location of spin probes in two phase mixed lipid systems, Biochim. Biophys. Acta 363:351–360 (1974).

    Article  Google Scholar 

  13. C. L. Bashford, C. G. Morgan and O. K. Radda, Measurement and interpretation of fluorescence polarizations in phospholipid dispersions, Biochim. Biophys. Acta 426:157–172 (1976).

    Article  Google Scholar 

  14. S. Mabrey and J.M. Sturtevant, Incorporation of saturated fatty acids into phosphatidylcholine bilayers, Biochim. Biophys. Acta 486:444–450 (1977).

    Google Scholar 

  15. D. M. LeNeveu, R. P. Rand and V. A. Parsegian, Measurement of forces between lecithin bilayers. Nature 259:601–603 (1976).

    Article  ADS  Google Scholar 

  16. W. L. Hubbell, J. C. Metcalfe, S. M. Metcalfe and H. M. McConnell, The interaction of small molecules with spin labelled erythrocyte membranes, Biochim. Biophys. Acta 219:415–427 (1970).

    Article  Google Scholar 

  17. D. Papahadjopoulos, K. Jacobson, G. Poste and G. Shepard, Effects of local anesthetics on membrane properties. 1. Changes in the fluidity of phospholipid bilayers, Biochim. Biophys. Acta 394: 504–519 (1975).

    Article  Google Scholar 

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© 1980 Plenum Press, New York

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Massari, S., Colonna, R. (1980). Role of a “Critical” Fatty Acid Concentration on Phospholipid Exchange and Size Enlargement of Sonicated Vesicles. In: Borsellino, A., Omodeo, P., Strom, R., Vecli, A., Wanke, E. (eds) Developments in Biophysical Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1077-8_19

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  • DOI: https://doi.org/10.1007/978-1-4684-1077-8_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1079-2

  • Online ISBN: 978-1-4684-1077-8

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