Abstract
In recent times fatty acids were used not only as probes for the phospholipid bilayer structure, but also as inducers of important biological processes such as membrane fusion (1), membrane permeability changes (2), phospholipid exchange (3,4) and phospholipid vesicle size enlargement (3–7). These observations point out that fatty acids, having a higher concentration in heart and brain than in other tissues, may play an important role in regulating many biological functions. In the present work the role of fatty acids in phospholipid exchange and in vesicle size enlargement is investigated.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
J. I. Howell, D. Fisher, A. H. Goodall, M. Verrinder and J. A. Lucy, Interactions of membrane phospholipids with fusogenic lipids, Biochim. Biophys. Acta 332:1–10 (1973).
R. Hori, Y. Kagimoto, K. Kamiya and K. J. luni. Effects of free fatty acids as membrane components on permeability of drugs across bilayer lipid membranes. A mechanism for intestinal absorption of acidic drugs, Biochim. Biophys. Acta 509:510–518 (1978).
J. M. H. Kremer and P. H. Wiersema, Exchange and aggregation in dispersions of dimiristoyl phosphatidylcholine vesicles containing myristic acid, Biochim. Biophys. Acta 471:348–360 (1977).
D. Papahadjopoulos, S. Hui, W. J. Vail and G. Poste, Studies on membrane fusion. 1. Interaction of pure phospholipid membranes and the effect of myristic acid, lysolecithin, proteins and dimethylsulfoxide, Biochim. Biophys. Acta 448:245–264 (1976).
H. L. Kantor and J. H. Prestegard, Fusion of fatty acid containing lecithin vesicles, Biochemistry 14: 1790–1795 (1975).
H. L. Kantor, S. Mabrey, J.H. Prestegard and J.M. Sturtevant, A calorimetric examination of stable and fusing lipid bilayer vesicles, Biochim. Biophys. Acta 466:402–410 (1977).
H. L. Kantor and J. H. Prestegard, Fusion of phosphatidylcholine bilayer vesicles: role of free fatty acid, Biochemistry 17: 3592–3597 (1978).
J. R. Usher, R. M. Epand and D. Papahadjopoulos, The effect of free fatty acids on the thermotropic phase transition of dimiristoylglicerophosphocholine, Chem. Phys. Lipids 22:245–253 (1978).
F. Podo and J. K. Blasie, Proton magnetic relaxation studies of mixed phosphatidylcholine fatty acid and mixed phosphatidylcholine bimolecular bilayers, Biochim. Biophys. Acta 419:1–18 (1976).
A.W. Eliasz, D. Chapman and D.F. Ewing, Phospholipid phase transitions. Effects of n-alcohols, n-monocarboxylic acids, phenylalkyl alcohols and quaternary ammonium compounds, Biochim. Biophys. Acta 448:220–230 (1976).
A.C. Lee, Functional properties of biological membranes. A physical-chemical approach, Prog. Biophys. Molec. Biol. 29: 3–56 (1975).
K. W. Butler, N. H. Tattrie and I. C. P. Smith, The location of spin probes in two phase mixed lipid systems, Biochim. Biophys. Acta 363:351–360 (1974).
C. L. Bashford, C. G. Morgan and O. K. Radda, Measurement and interpretation of fluorescence polarizations in phospholipid dispersions, Biochim. Biophys. Acta 426:157–172 (1976).
S. Mabrey and J.M. Sturtevant, Incorporation of saturated fatty acids into phosphatidylcholine bilayers, Biochim. Biophys. Acta 486:444–450 (1977).
D. M. LeNeveu, R. P. Rand and V. A. Parsegian, Measurement of forces between lecithin bilayers. Nature 259:601–603 (1976).
W. L. Hubbell, J. C. Metcalfe, S. M. Metcalfe and H. M. McConnell, The interaction of small molecules with spin labelled erythrocyte membranes, Biochim. Biophys. Acta 219:415–427 (1970).
D. Papahadjopoulos, K. Jacobson, G. Poste and G. Shepard, Effects of local anesthetics on membrane properties. 1. Changes in the fluidity of phospholipid bilayers, Biochim. Biophys. Acta 394: 504–519 (1975).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 Plenum Press, New York
About this chapter
Cite this chapter
Massari, S., Colonna, R. (1980). Role of a “Critical” Fatty Acid Concentration on Phospholipid Exchange and Size Enlargement of Sonicated Vesicles. In: Borsellino, A., Omodeo, P., Strom, R., Vecli, A., Wanke, E. (eds) Developments in Biophysical Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1077-8_19
Download citation
DOI: https://doi.org/10.1007/978-1-4684-1077-8_19
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-1079-2
Online ISBN: 978-1-4684-1077-8
eBook Packages: Springer Book Archive