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Immunology of Neisseria meningitidis

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Immunology of Human Infection

Part of the book series: Comprehensive Immunology ((COMIMUN,volume 8))

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Abstract

Meningococcal disease has been a worldwide problem for many centuries. The meningococcus, Neisseria meningitidis, first described by Weichselbaum in 1887, is a gram-negative, kidney-bean-shaped organism found both intraand extracellularly.

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References

  • Amato Neto, V., Finger, H., Gotschlich, E.C, Feldman, R.A., Avila, C.A. de, Konicki, S.R., and Laus, W.C., 1974, Serologic response to serogroup C meningococcal vaccine in Brazilian preschool children, Rev. Inst. Med. Trop. Sao Paulo 16:149–153.

    PubMed  CAS  Google Scholar 

  • Ammann, A.J., Addiego, J., Wara, D.W., Lubin, B., Smith, W.B., and Mentzer, W.C., 1977, Polyvalent pneumococcal-polysaccharide immunization of patients with sickle-cell anemia and patients with splenectomy, N. Engl. J. Med. 297:897–900.

    Article  PubMed  CAS  Google Scholar 

  • Anderson, P., and Smith, D.H., 1977, Immunogenicity in weanling rabbits of a polyribophosphate complex from Haemophilus influenzae Type b, J. Infect. Dis. 136:S63–S70.

    Article  PubMed  Google Scholar 

  • Apicella, M.A., 1974, Identification of a subgroup antigen on the Neisseria meningitidis group C capsular Polysaccharide, J. Infect. Dis. 129:147–153.

    Article  PubMed  CAS  Google Scholar 

  • Artenstein, M.S., 1971, Meningococcal infections. 5. Duration of Polysaccharide-vaccine-induced antibody. Bull. WHO 45:291–293.

    CAS  Google Scholar 

  • Artenstein, M.S., and Brandt, B.L., 1975, Immunologic hyporesponsiveness in man to group C meningococcal Polysaccharide, J. Immunol. 115:5–7.

    PubMed  CAS  Google Scholar 

  • Artenstein, M.S., Rust, J.H., Hunter, D.H., Lamson, T.H., and Buescher, E.L., 1967, Acute respiratory disease and meningococcal infection in Army recruits, JAMA 201:1004–1008.

    Article  PubMed  CAS  Google Scholar 

  • Artenstein, M.S., Gold, R., Zimmerly, J.G., Wyle, F.A., Branche, W.C., Jr., and Harkins, C., 1970a, Cutaneous reactions and antibody responses to meningococcal group C vaccines in man, J. Infect. Dis. 121:372–377.

    Article  PubMed  CAS  Google Scholar 

  • Artenstein, M.S., Gold, R., Zimmerly, J.G., Wyle, F., Schneider, H., and Harkin, C., 1970b, Prevention of meningococcal disease by group C Polysaccharide vaccine, N. Engl. J. Med. 282:417–420.

    Article  PubMed  CAS  Google Scholar 

  • Artenstein, M.S., Schneider, H., and Tingley, M.D., 1971a, Meningococcal infections. 1. Prevalence of serogroups causing disease in U.S. Army personnel in 1964–1970, Bull. WHO 45:275–278.

    PubMed  CAS  Google Scholar 

  • Artenstein, M.S., Branche, W.C., Jr., Zimmerly, J.G., Cohen, R.L., Tramont, E.C., Kasper, D.L., and Harkins, C, 1971b, Meningococcal infections. 3. Studies of the group A Polysaccharide vaccines, Bull. WHO 45:283–286.

    PubMed  CAS  Google Scholar 

  • Artenstein, M.S., Brandt, B.L., Tramont, E.C., Branche, W.C., Jr., Fleet, H.D., and Cohen, R.L., 1971c, Serologie studies of meningococcal infection and Polysaccharide vaccination, J. Infect. Dis. 124:277–288.

    Article  PubMed  CAS  Google Scholar 

  • Artenstein, M.S., Winter, P.E., Gold, R., and Smith, C.D., 1974, Immunoprophylaxis of meningococcal infection, Milit. Med. 139:91–95.

    CAS  Google Scholar 

  • Baltimore, R.S., and Hammerschlag, M., 1977, Meningococcal bacteremia — Clinical and serologie studies of infants with mild illness, Am. J. Dis. Child. 131:1001–1004.

    PubMed  CAS  Google Scholar 

  • Bertram, M.A., Griffiss, J.M., and Brand, D.D., 1976, Response to antigenic determinants on Neisseria meningitidis lipopolysaccharide investigated with a new radioactive antigen-binding assay, J. Immunol. 116:842–846.

    PubMed  CAS  Google Scholar 

  • Bhattacharjee, A.K., Jennings, H.J., and Kenny, C.P., 1974, Characterization of 3-deoxy-D-manno octulosonic acid as a component of the capsular Polysaccharide antigen from Neisseria meningitidis serogroup 29E, Biochem. Biophys. Res. Commun. 61:489–493.

    Article  PubMed  CAS  Google Scholar 

  • Bhattacharjee, A.K., Jennings, H.J., Kenny, C.P., Martin, A., and Smith, I.C.P., 1975, Structural determinations of the sialic acid Polysaccharide antigens of Neisseria meningitidis serogroups B and C with carbon 13 nuclear magnetic resonance, J. Biol. Chem. 250:1926–1932.

    PubMed  CAS  Google Scholar 

  • Bhattacharjee, A.K., Jennings, H.J., Kenny, C.P., Martin, A., and Smith I.C.P., 1976, Structural determination of the Polysaccharide antigens of Neisseria meningitidis serogroups Y, W-135, and BO, Can. J. Biochem. 54:1–8.

    PubMed  CAS  Google Scholar 

  • Brandt, B.L., and Artenstein, M.S., 1975, Duration of antibody responses after immunization with Group C Neisseria meningitidis Polysaccharide, J. Infect. Dis. 131:S69–S75.

    Article  PubMed  Google Scholar 

  • Brandt, B.L., Wyle, F.A., and Artenstein, M.S., 1972, A radioactive antigen-binding assay for Neisseria meningitidis Polysaccharide antibody, J. Immunol. 108:913–920.

    PubMed  CAS  Google Scholar 

  • Branham, S.E., 1956, Milestones in the history of the meningococcus, Can. J. Microsec. 2:175–188.

    Article  CAS  Google Scholar 

  • Bundle, D.R., Smith, I.C.P., and Jennings, H.J., 1974, Determination of the structure and conformation of bacterial Polysaccharides by C13 nuclear magnetic resonance: Studies on the group-specific antigens of Neisseria meningitis serogroups A and X, J. Biol. Chem. 249:2275–2281.

    PubMed  CAS  Google Scholar 

  • Carvalho, A., Giampaglia, C., Kimura, H., Pereira, O., Farhat, C., Neves, J., Prandini, R., Carvalho, E., and Zarvos, A.M., 1977, Maternal and infant antibody response to meningococcal vaccination in pregnancy, Lancet 2:809–811.

    Article  Google Scholar 

  • Chilcote, R.R., Baehner, R.L., and Hammond, D., 1976, Septicemia and meningitis in children splenectomized for Hodgkin’s disease, N. Engl. J. Med. 295:798–800.

    Article  PubMed  CAS  Google Scholar 

  • Davis, C.E., and Arnold, K., 1974, Role of meningococcal endotoxin in meningococcal purpura, J. Exp. Med. 140:159–171.

    Article  PubMed  CAS  Google Scholar 

  • DeMorais, J.S., Munford, R.S., Risi, J.B., Antezana, E., and Feldman, R.A., 1974, Epidemic disease due to serogroup C Neisseria meningtidis in Sao Paolo, Brazil, J. Infect. Dis. 129:568–571.

    Article  Google Scholar 

  • Devine, L.F., Pierce, W.E., Floyd, T.M., Rhode, S.L., Edwards, E.A., Siess, E.E., and Peckingpaugh, R.O., 1970, Evaluation of group C meningococcal Polysaccharide vaccine in marine recruits, San Diego, California, Am. J. Epidemiol. 92:25–32.

    PubMed  CAS  Google Scholar 

  • Dickerman, J.D., 1976, Bacterial infection and the asplenic host: A review, J. Trauma 16:662–668.

    Article  PubMed  CAS  Google Scholar 

  • Eickhoff, T.C., 1971, Sero-epidemiologic studies of meningococcal infections with the indirect hemagglutination test, J. Infect. Dis. 123:519–526.

    Article  PubMed  CAS  Google Scholar 

  • Eraklis, A.J., and Filler, R.M., 1972, Splenectomy in childhood: A review of 1413 cases, J. Pediatr. Surg. 7:382–388.

    Article  PubMed  CAS  Google Scholar 

  • Erwa, H.H., Satti, M.H., and Abbas, A.M., 1971, Cerebrospinal meningitis in the Sudan, Sudan Notes Rec. 52:101–109.

    Google Scholar 

  • Erwa, H.H., Haseeb, M.A., Idris, A.A., Lapeyssonie, L., Sanborn, W.R., and Sippel, J.E., 1973, A serogroup A meningococcal Polysaccharide vaccine, Bull. WHO 49:301–305.

    PubMed  CAS  Google Scholar 

  • Evans-Jones, L.G., Whittle, H.C., Onyewotu, I.L, Egler, L.J., and Greenwood, B.M., 1977, Comparative study of group A and group C meningococcal infection, Arch. Dis. Child. 52:320–323.

    Article  PubMed  CAS  Google Scholar 

  • Farquhar, J.D., Hankens, W.A., DeSanctis, A.N., DeMeio, J.L., and Metzgar, D.P., 1977, Clinical and serological evaluation of purified Polysaccharide vaccines prepared from Neisseria meningitidis group Y (39828), Proc. Soc. Exp. Biol. Med. 155:453–455.

    PubMed  CAS  Google Scholar 

  • Fass, R.J., and Saslaw, S., 1972, Chronic meningococcemia: Possible pathogenic role of IgM deficiency, Arch. Intern. Med. 130:943–946.

    Article  PubMed  CAS  Google Scholar 

  • Feldman, R.A., Koehler, R.E., and Fraser, D.W., 1976, Race-specific differences in bacterial meningitis death rates in the United States 1962–1968, Am. J. Publ. Health 66:392–396.

    Article  CAS  Google Scholar 

  • Flexner, S., 1913, The results of the serum treatment in 1300 cases of epidemic meningitis, J. Exp. Med. 17:553–576.

    Article  PubMed  CAS  Google Scholar 

  • Frasch, C.E., 1977, Role of protein serotype antigens in protection against disease due to Neisseria meningitidis, J. Infect. Dis. 136:S84–S90.

    Article  PubMed  Google Scholar 

  • Frasch, C.E., and Chapman, S.S., 1972a, Classification of Neisseria meningitidis group B into distinct serotypes. I. Serological typing by a microbacterial method, Infect. Immun. 5:98–102.

    PubMed  CAS  Google Scholar 

  • Frasch, C.E., and Chapman, S.S., 1972b, Classification of Neisseria group B into distinct serotypes. II. Extraction of type-specific antigens for serotyping by precipitin techniques, Infect. Immunol. 6:127–133.

    CAS  Google Scholar 

  • Frasch, C.E., and Chapman, S.S., 1973, Classification of Neisseria meningitidis group B into distinct serotypes. III. Application of a new bactericidal inhibition technique to distribution of serotypes among cases and carriers, J. Infect. Dis. 127:149–154.

    Article  PubMed  CAS  Google Scholar 

  • Frasch, C.E., and Gotschlich, E.C., 1974, An outer membrane protein of Neisseria meningitidis group B responsible for serotype specificity, J. Exp. Med. 140:87–104.

    Article  PubMed  CAS  Google Scholar 

  • Frasch, C.E., McNelis, R.M., and Gotschlich, E.C., 1976, Strain specific variation in the protein and lipopolysaccharide composition of the group B meningococcal outer membrane, J. Bacteriol. 127:973–981.

    PubMed  CAS  Google Scholar 

  • Fraser, D.W., Darby, C.P., Koehler, R.E., Jacobs, C.F., and Feldman, R.A., 1973, Risk factors in bacterial meningitis: Charleston County, South Carolina, J. Infect. Dis. 127:271–277.

    Article  PubMed  CAS  Google Scholar 

  • Gavrilis, P., Rothenberg, S.P., and Guy, R., 1974, Correlation of low serum IgM levels with absence of functional splenic tissue in sickle cell disease syndromes, Am. J. Med. 57:542–545.

    Article  PubMed  CAS  Google Scholar 

  • Gold, R., and Artenstein, M.S., 1971, Meningococcal infections. 2. Field trial of group C meningoccocal Polysaccharide vaccine in 1969–70, Bull WHO 45:279–282.

    PubMed  CAS  Google Scholar 

  • Gold, R., and Lepow, M.L., 1976, Present status of Polysaccharide vaccines in the prevention of meningococcal disease, Adv. Pediatr. 23:71–93.

    PubMed  CAS  Google Scholar 

  • Gold, R., and McLean, R. H., 1978, Absence of the sixth component of complement in a child with chronic meningococcemia, Pediatr. Res. 12:480 (abstr.).

    Article  Google Scholar 

  • Gold, R., and Wyle, F.A., 1970, New classification of N. meningiditis by means of bactericidal reactions, Infect. Immun. 1:479–484.

    PubMed  CAS  Google Scholar 

  • Gold, R., Winklehake, J.L., Mars, R.S., and Artenstein, M.S., 1971, Identification of an epidemic strain of group C Neisseria meningitidis by bactericidal serotyping, J. Infect. Dis. 124:593–597.

    Article  PubMed  CAS  Google Scholar 

  • Gold, R., Lepow, M.L., Goldschneider, I., Draper, T.L., and Gotschlich, E.C., 1976, Clinical evaluation of group A and group C meningococcal Polysaccharide vaccines in infants, J. Clin. Invest. 56:1536–1547.

    Article  Google Scholar 

  • Gold, R., Lepow, M.L., Goldschneider, I., Gotschlich, E.C, DeSanctis, A.N., and Metzgar, D.P., 1977a, Immunogenicity of groups A and C meningococcal polysaccharides of differing molecular weights, Pediatr. Res. 11:500.

    Google Scholar 

  • Gold, R., Lepow, M.L., Goldschneider, I., and Gotschlich, E.C., 1977b, Immune response of human infants to Polysaccharide vaccines of groups A and C Neisseria meningitidis, J. Infect. Dis. 136:S31–S35.

    Article  PubMed  Google Scholar 

  • Gold, R., Goldschneider, I., Lepow, M.L., Draper, T.F., and Randolph, M., 1978a, Carriage of Neisseria meningitidis and Neisseria lactamica in infants and children, J. Infect. Dis. 137:112–121.

    Article  PubMed  CAS  Google Scholar 

  • Gold, R., Lepow, M.L., Goldschneider, I., and Gotschlich, E.C., 1978b, Antibody responses of human infants to 3 doses of group A meningococcal Polysaccharide vaccine administered at 3, 4 and 6 months of age, J. Infect. Dis. 138:731–735.

    Article  PubMed  CAS  Google Scholar 

  • Gold, R., Lepow, M. L., and Randolph, M., 1978c, Natural immunity to pyogenic bacteria, Pediatr. Res. 12:492 (abstr.).

    Article  Google Scholar 

  • Goldschneider, I., Gotschlich, E.C., and Artenstein, M.S., 1969a, Human immunity to the meningococcus. I. Role of humoral antibodies, J. Exp. Med. 129:1307–1326.

    Article  PubMed  CAS  Google Scholar 

  • Goldschneider, I., Gotschlich, E.C., and Artenstein, M.S., 1969b, Human immunity to the meningococcus. II. Development of natural immunity, J. Exp. Med 129:1327–1348.

    Article  PubMed  CAS  Google Scholar 

  • Goldschneider, I., Lepow, M.L., and Gotschlich, E.C., 1972, Immunogenicity of the group A and group C meningococcal Polysaccharides in children, J. Infect. Dis. 125:509–519.

    Article  PubMed  CAS  Google Scholar 

  • Goldschneider, I., Lepow, M.L., Gotschlich, C., Mauck, F.T., Bachl, F., and Randolph, M., 1973, Immunogenicity of group A and group C meningococcal Polysaccharides in human infants, J. Infect. Dis. 128:769–776.

    Article  PubMed  CAS  Google Scholar 

  • Gotschlich, E.C., 1975, Development of Polysaccharide vaccines for the prevention of meningococcal diseases, Monogr. Allergy 9:245–248.

    PubMed  CAS  Google Scholar 

  • Gotschlich, E.C., Liu, T.Y., and Artenstein, M.S., 1969a, Human immunity to the meningococcus. III. Preparation and immunochemical properties of the group A, group B and group C meningococcal Polysaccharides, J. Exp. Med. 129:1349–1365.

    Article  PubMed  CAS  Google Scholar 

  • Gotschlich, E.C., Goldschneider, I., and Artenstein, M.S., 1969b, Human immunity to the meningococcus. IV. Immunogenicity of group A and group C meningococcal Polysaccharides in human volunteers, J. Exp. Med. 129:1367–1384.

    Article  PubMed  CAS  Google Scholar 

  • Gotschlich, E.C., Goldschneider, I., and Artenstein, M.S., 1969c, Human immunity to the meningococcus. V. The effect of immunization with meningococcal group C Polysaccharide on the carrier state, J. Exp. Med. 129:1385–1395.

    Article  PubMed  CAS  Google Scholar 

  • Gotschlich, E.C., Rey, M., Triau, R., and Sparks, K.J., 1972, Quantitative determination of the human immune response to immunization with meningococcal vaccines, J. Clin. Invest 51:89–96.

    Article  PubMed  CAS  Google Scholar 

  • Gotschlich, E. C., Goldschneider, I., Lepow, M. L., and Gold, R., 1976, Immune response to bacterial Polysaccharides in man, in: Antibodies in Human Diagnosis and Therapy (E. Habar and R. M. Krause, ed.), pp. 391–403, Raven Press, New York.

    Google Scholar 

  • Greenwood, B.M., Whittle, H.C., and Bryceson, A.D.M., 1973, Allergic complications of meningococcal disease. II. Immunological investigations, Br. Med. J. 2:737–740.

    Article  PubMed  CAS  Google Scholar 

  • Griffiss, J.M., Broud, D.M., Silver, C.A., and Artenstein, M.S., 1977, Immunoepidemiology of meningococcal disease in military recruits. I. A model for serogroup independency of epidemic potential as determined by serotyping, J. Infect. Dis. 136:176–186.

    Article  PubMed  CAS  Google Scholar 

  • Hobbs, J.R., Milner, R.D.G., and Watt, P.J., 1967, Gamma-M deficiency predisposing to meningococcal septicaemia, Br. Med. J. 4:583–586.

    Article  PubMed  CAS  Google Scholar 

  • Johnston, R.B., Jr., Newman, S.L., and Struth, A.G., 1973, An abnormality of the alternative pathway of complement activation in sickle cell disease, N. Engl. J. Med. 288:803–808.

    Article  PubMed  Google Scholar 

  • Kabat, E.A., and Bezer, A.E., 1958, The effect of variation in molecular weight in the antigenicity of dextran in man, Arch. Biochem. Biophys. 78:306–318.

    Article  PubMed  CAS  Google Scholar 

  • Kabat, E.A., Kaiser, H., and Sikorski, H., 1944, Preparation of type-specific Polysaccharide of the type 1 meningococcus and a study of its effectiveness as an antigen in human beings, J. Exp. Med. 80:299–307.

    Article  PubMed  CAS  Google Scholar 

  • Kasper, D.L., Winkelhake, J.L., Brandt, B.L., and Artenstein, M.S., 1973, Antigenic specificity of bactericidal antibodies in antisera to Neisseria meningitides, J. Infect. Dis. 127:378–387.

    Article  PubMed  CAS  Google Scholar 

  • Kuronen, T., Peltola, H., Nors, T., Haque, H., and Makela, P.H., 1977, Adverse reactions and endotoxin content of Polysaccharide vaccines, Dev. Biol. Stand. 34:117–125.

    PubMed  CAS  Google Scholar 

  • Lepow, M.L., Goldschneider, I., Gold, R., Randolph, M., and Gotschlich, E.C., 1977, Persistence of antibody following immunization of children with groups A and C meningococcal Polysaccharide vaccines, Pediatrics 60:673–680.

    PubMed  CAS  Google Scholar 

  • Lim, D., Gewurz, A., Lint, T.F., Ghaze, M., Sepheri, B., and Gewurz, H., 1976, Absence of the sixth component of complement in a patient with repeated episodes of meningococcal meningitis, J. Pediatr. 89:42–47.

    Article  PubMed  CAS  Google Scholar 

  • Liu, T.Y., Gotschlich, E.C., Jonssen, E.K., and Wysocki, J.R., 1971a, Studies on the meningococcal polysaccharides. I. Composition and chemical properties of the group A Polysaccharide, J. Biol. Chem. 246:2849–2858.

    PubMed  CAS  Google Scholar 

  • Liu, T.Y., Gotschlich, E.C., Dunne, F.T., and Jonssen, E.K., 1971b, Studies on the meningococcal Polysaccharides. II. Composition and chemical properties of the group B and C Polysaccharides, J. Biol. Chem. 246:4703–4712.

    PubMed  CAS  Google Scholar 

  • Makela, P.H., Kayhty, H., Weckstrom, P., Sivonen, A., and Renkonen, O.-V., 1975, Effect of group A meningococcal vaccine in Army recruits in Finland, Lancet 2:883–886.

    Article  PubMed  CAS  Google Scholar 

  • Makela, P.H., Peltola, H., Kayhty, H., Jousimies, H., Pettay, O., Ruoslahti, E., Sivonen, A., and Renkonen, O.-V., 1977, Polysaccharide vaccines of group A Neisseria meningitidis and Haemophilus influenzae type b: A field trial in Finland, J. Infect. Dis. 136:S43–S50.

    Article  PubMed  Google Scholar 

  • McCormick, J.B., Weaver, R.E., Thornsberry, C., and Feldman, R.A., 1974, Trends in disease caused by Neisseria meningitidis: 1972 and 1973, J. Infect. Dis. 130:212–214.

    Article  PubMed  CAS  Google Scholar 

  • Meningococcal Surveillance Group, 1976, Analysis of endemic meningococcal disease by serogroup and evaluation of chemoprophylaxis, J. Infect. Dis. 134:201.

    Article  Google Scholar 

  • Millar, J.W., Siess, E.E., and Feldman, H.A., Silberman, C., and Frank, P., 1963, In vivo and in vitro resistance to sulfadiazine in strains of Neisseria meningitides, JAMA 186:139–141.

    Article  PubMed  CAS  Google Scholar 

  • Monto, A.S., Brandt, B.L., and Artenstein, M.S., 1973, Response of children to Neisseria meningitidis Polysaccharide vaccines, J. Infect. Dis. 127:394–400.

    Article  PubMed  CAS  Google Scholar 

  • Morbidity Mortality Weekly Report, 1975, Meningococcal Polysaccharide vaccines, Morbid. Mortal. Wkly. Rep. 25:381–382.

    Google Scholar 

  • Morbidity Mortality Weekly Report, 1976, Reported morbidity and mortality in the United States, Morbid. Mortal. Wkly. Rep. 25(53):50.

    Google Scholar 

  • Morbidity Mortality Weekly Report, 1977, Follow-up on meningococcal disease — Alaska, Oregon, Washington, Morbid. Mortal. Wkly. Rep. 26:101–102.

    Google Scholar 

  • Munford, R.S., and Gorman, G.W., 1974, Serotyping Neisseria meningitidis, Lancet 2:177.

    Article  PubMed  CAS  Google Scholar 

  • Munford, R.S., Taunay, A. de E., deMorais, J.S., Fraser, D.W., and Feldman, R.A., 1974, Spread of meningococcal infection within households, Lancet 1:1275–1278.

    Article  PubMed  CAS  Google Scholar 

  • Munford, R.S., Patton, C.M., and Gorman, G.W., 1975, Epidemiological studies of antigens common to groups B and C Neisseria meningitidis, J. Infect. Dis. 131:286–290.

    Article  PubMed  CAS  Google Scholar 

  • Nicholson, A., and Lepow, J. H., 1978, Role of complement in defense against N. meningiditis, Clin. Res. 26:525A.

    Google Scholar 

  • Peltola, H., 1977, Group A meningococcal and Haemophilus influenzae type b capsular Polysaccharide vaccines in infants and children under school age, Ph.D. thesis, 72 pp., Helsinki, Finland.

    Google Scholar 

  • Peltola, H., Makela, P.H., Kayhty, H., Jousimies, H., Herva, E., Hallstrom, H., Sivonen, A., Renkonen, O.-V., Pettay, O., Karanko, V., Ahvonen, P., and Sarna, S., 1977, Clinical efficacy of meningococcus group A capsular Polysaccharide vaccine in children 3 months to 5 years of age, N. Engl. J. Med. 297:686–691.

    Article  PubMed  CAS  Google Scholar 

  • Petersen, B.H., Graham, J.A., and Brooks, G.E., 1976, Human deficiency of the eighth component of complement: The requirement for C8 for serum Neisseria gonorrhoeae bactericidal activity, J. Clin. Invest. 57:283–290.

    Article  PubMed  CAS  Google Scholar 

  • Pfair, J. J., 1958, Meningococcal meningitis, in: Preventive Medicine in World War II, Vol. IV: Communicable Diseases Transmitted Chiefly through Respiratory and Alimentary Tracts (J. B. Coates, Jr., ed.), pp. 191–209, Office of the Surgeon General Department of the Army, Washington, D.C.

    Google Scholar 

  • Relier, L.B., MacGregor, R.R., and Beaty, H.N., 1973, Bactericidal antibody after colonization with Neisseria meningitidis, J. Infect. Dis. 127:56–62.

    Article  Google Scholar 

  • Robbins, J.B., Schneerson, R., Glode, M.P., Vann, W., Schiffer, M.S., Liu, T.Y., Parke, J.C., and Huntley, C., 1975, Cross-reactive antigens and immunity to diseases caused by encapsulated bacteria, J. Allergy Clin. Immunol. 56:141–151.

    Article  PubMed  CAS  Google Scholar 

  • Roberts, R.B., 1970, The relationship between group A and C meningococcal Polysaccharides and serum opsonins in man, J. Exp. Med. 131:499–513.

    Article  PubMed  CAS  Google Scholar 

  • Rosen, F.S., and Janeway, C.A., 1966, The gammaglobulins. III. The antibody deficiency syndromes, N. Engl. J. Med. 275:709–715, 769-775.

    Article  PubMed  CAS  Google Scholar 

  • Seeler, R.A., Metzger, W., and Mufson, M.A., 1972, Diplococcus pneumoniae infections in children with sickle cell anemia, Am. J. Dis. Child. 123:8–10.

    PubMed  CAS  Google Scholar 

  • Taunay, A. de E., Galvao, P.A., deMorais, J.A., Gotschlich, E.C., and Feldman, R.A., 1974, Disease prevention by meningococcal serogroup C Polysaccharide vaccine in preschool children, Pediatr. Res. 8:429.

    Article  Google Scholar 

  • Vassiliades, P., Kanellakis, A., and Papadakis, J., 1969, Sulfadiazine-resistant group A meningococci isolated during the 1968 meningitis epidemic in Greece, J. Hyg. 67:279–288.

    Article  Google Scholar 

  • Wahdan, M.H., Rizk, F., El-Akkad, A.M., El-Ghoroury, A.A., Hablas, R., Girgis, N.I., Amer, A., Boctar, W., Sippel, J.E., Gotschlich, E.C., Triau, R., Sanborn, W.R., and Cvjetanovic, B., 1973, A controlled field trial of a serogroup A meningococcal Polysaccharide vaccine, Bull. WHO 48:667–673.

    PubMed  CAS  Google Scholar 

  • Weekly Epidemiological Record, 1975, Meningitis, Argentina, Wkly. Epidemiol. Rec. 50:161.

    Google Scholar 

  • Weekly Epidemiological Record, 1976, Meningococcal meningitis, Wkly. Epidemiol. Rec. 51:333–334.

    Google Scholar 

  • Whittle, H.C., and Greenwood, B.M., 1976, Meningococcal meningitis in the norther savannah of Africa, Trop. Doc. 6:99–104.

    CAS  Google Scholar 

  • Whittle, H.C., Abdullahi, M.T., Fakunle, F.A., Greenwood, B.M., Bryceson, A.D.M., Parry, E.H.O., and Turk, J.L., 1973, Allergic complications of meningococcal disease. I. Clinical aspects, Br. Med. J. 2:733–737.

    Article  PubMed  CAS  Google Scholar 

  • Winkestein, J.A., and Drachman, R.H., 1968, Deficiency of pneumococcal serum opsonizing activity in sicklecell disease. N. Engl. J. Med. 279:459–466.

    Article  Google Scholar 

  • Wong, H.H., Barrera, O., Sutton, A., May, J., Hochstein, D.H., Robbins, J.D., Robbins, J.B., Parkman, P.D., and Seligman, E.B., Jr., 1977, Standardization and control of meningococcal vaccines, group A and group C Polysaccharides, J. Biol. Stand. 5:197–215.

    Article  PubMed  CAS  Google Scholar 

  • Wyle, F.A., Artenstein, M.S., Brandt, B.L., Tramont, E.C., Kasper, D.L., Altieri, P.L., Berman, S.L., and Lowenthal, L.P., 1972, Immunologic response of man to group B meningococcal Polysaccharide vaccines, J. Infect. Dis. 126:514–522.

    Article  PubMed  CAS  Google Scholar 

  • Young, L.S., LaForce, F.M., Head, J.J., Feely, J.C., and Bennett, J.V., 1972, A simultaneous outbreak of meningococcal and influenzae infections, N. Engl. J. Med. 287:5–9.

    Article  PubMed  CAS  Google Scholar 

  • Zollinger, W.D., Pennington, C.L., and Artenstein, M.S., 1974, Human antibody response to three meningococcal outer membrane antigens: Comparison by specific hemagglutination assays, Infect. Immun. 10:975–984.

    PubMed  CAS  Google Scholar 

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© 1981 Plenum Publishing Corporation

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Lepow, M.L., Gold, R. (1981). Immunology of Neisseria meningitidis . In: Nahmias, A.J., O’Reilly, R.J. (eds) Immunology of Human Infection. Comprehensive Immunology, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1009-9_6

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  • DOI: https://doi.org/10.1007/978-1-4684-1009-9_6

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