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Surface Carbohydrate Alterations of Mutant Mammalian Cells Selected for Resistance to Plant Lectins

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The Biochemistry of Glycoproteins and Proteoglycans

Abstract

In recent years it has become possible to select mutants of mammalian cells which exhibit structural alterations in the carbohydrate moieties of cell surface glycoproteins and glycolipids. The selective agents which have enabled the isolation of these mutants are the cytotoxic plant lectins. These include the phytohemagglutinin from Phaseolus vulgaris (PHA), agglutinins from wheat germ (WGA), concanavalin A from jack beans (Con A), toxin from Ricinus communis (RIC), and agglutinins from Lens culinaris (LCA).

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  1. Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, 10461, USA

    Pamela Stanley

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  1. Pamela Stanley
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  1. The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    William J. Lennarz

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© 1980 Plenum Press, New York

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Stanley, P. (1980). Surface Carbohydrate Alterations of Mutant Mammalian Cells Selected for Resistance to Plant Lectins. In: Lennarz, W.J. (eds) The Biochemistry of Glycoproteins and Proteoglycans. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1006-8_4

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  • DOI: https://doi.org/10.1007/978-1-4684-1006-8_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1008-2

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