Abstract
Restricted heterogeneity of the cerebrospinal fluid (CSF) γ globulins was discovered through the use of agar gel electrophoresis. That discovery came at the end of an extensive procedure which was technical as well as theoretical. Many problems had to be tackled, only some were solved. First, we shall refer to the technical problems, then to the neurological diseases in which restricted heterogeneity is found, then deal with physio-pathological problems and finally make a suggestion regarding terminology.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Kerenyi, L. and Pallyas F. A highly sensitive method for demonstrating proteins in electrophoretic, immunoelectrophoretic and immunodiffusion preparation. Clin. Chim. Acta 38, 465, 1972.
Delmotte, P. Comparative results of agar electrophoresis and isoelectric focusing examination of the y globulins of the cerebrospinal fluid. Acta Neurol. Belg. 72, 226, 1972.
Glasner, H. Die diagnostische Bedeutung der Mikrozonenelektro-phorese des nicht eingeengten Liquor cerebrospinalis. Dtsch. med. Wschr. 103, 1173, 1978.
Kabat, E.A., Landow, H. and Moore, D.H. Cerebrospinal Fluid Electrophoresis. Proc. Soc. exp. Biol. 49, 260, 1942.
Kabat, E.A., Moore, D.H. and Landow, H. Electrophoretic study of proteins in CSF and their relationship to the serum proteins. J. Clin. Invest. 21, 7571, 1942.
Karcher, D., van Sande, M. and Lowenthal, A. Microelectrophoresis in agar gel of the proteins of the cerebrospinal fluid and central nervous system. J. Neurochem. 4, 135, 1959.
Lowenthal, A. The problem of cerebrospinal studies in multiple sclerosis. In Multiple Sclerosis, a clinical conspectus. Ed. E.J. Field, MTT Press Ltd. p. 207, 1977.
Sigurdsson, B., Karcher, D., van Sande, M. and Lowenthal, A. Electrophoresis of the serum and the CSF proteins in sheep neurological diseases. Protides of the Biological Fluids, 8th Colloquium, Bruges, 1960. Elsevier, Amsterdam, p. 110, 1961.
Janssens, J. Homogene konijnen antilichamen tegen Micrococus Lysodeikticus. V.U.B. Faculteit Wetenschappen. Proefschrift licentiaat in de scheikundige wetenschappen, Sept. 1972.
Strosberg, A.D., Karcher, D. and Lowenthal, A. Structure and idiotype of human homogeneous antibodies. Fed. Proc. (abstr.) 969, 1975.
Prineas, J.W., Raine, C.S., Connell, F.. and Wright, R.G. Bound immunoglobulin G in chronic multiple sclerosis plaques. 11th World Congress of Neurology, Excerpta Medica, Amsterdam, 300, 1977.
Link, H. and Muller, R. Arch. Neurol. 25, 326, 1971.
Vandvik, B. and E. Norrby. Oligoclonal IgG antibody response with central nervous system to different measles virus antigens in SSPE. Proc. Nat. Sci. USA Vol. 70, pp 1060, 1973.
Vandvik, B. Gel-precipitating measles virus antibodies in SSPE Relation to oligoclonal IgG proteins in the CSF and serum, and the occurrence of two separate fractions of antibody to virus nucleocapsids. Acta Path. Microbiol. Scand. Sect. C. 85: 324, 1977
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1979 Plenum Press, New York
About this chapter
Cite this chapter
Lowenthal, A. (1979). Restricted Heterogeneity of the IgG in Neurology. In: Karcher, D., Lowenthal, A., Strosberg, A.D. (eds) Humoral Immunity in Neurological Diseases. NATO ASI Series, vol 24. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1003-7_37
Download citation
DOI: https://doi.org/10.1007/978-1-4684-1003-7_37
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-1005-1
Online ISBN: 978-1-4684-1003-7
eBook Packages: Springer Book Archive