Skip to main content

Restricted Heterogeneity of the IgG in Neurology

  • Chapter
Humoral Immunity in Neurological Diseases

Part of the book series: NATO ASI Series ((NSSA,volume 24))

Abstract

Restricted heterogeneity of the cerebrospinal fluid (CSF) γ globulins was discovered through the use of agar gel electrophoresis. That discovery came at the end of an extensive procedure which was technical as well as theoretical. Many problems had to be tackled, only some were solved. First, we shall refer to the technical problems, then to the neurological diseases in which restricted heterogeneity is found, then deal with physio-pathological problems and finally make a suggestion regarding terminology.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Kerenyi, L. and Pallyas F. A highly sensitive method for demonstrating proteins in electrophoretic, immunoelectrophoretic and immunodiffusion preparation. Clin. Chim. Acta 38, 465, 1972.

    Article  PubMed  CAS  Google Scholar 

  2. Delmotte, P. Comparative results of agar electrophoresis and isoelectric focusing examination of the y globulins of the cerebrospinal fluid. Acta Neurol. Belg. 72, 226, 1972.

    PubMed  CAS  Google Scholar 

  3. Glasner, H. Die diagnostische Bedeutung der Mikrozonenelektro-phorese des nicht eingeengten Liquor cerebrospinalis. Dtsch. med. Wschr. 103, 1173, 1978.

    Article  PubMed  CAS  Google Scholar 

  4. Kabat, E.A., Landow, H. and Moore, D.H. Cerebrospinal Fluid Electrophoresis. Proc. Soc. exp. Biol. 49, 260, 1942.

    CAS  Google Scholar 

  5. Kabat, E.A., Moore, D.H. and Landow, H. Electrophoretic study of proteins in CSF and their relationship to the serum proteins. J. Clin. Invest. 21, 7571, 1942.

    Article  Google Scholar 

  6. Karcher, D., van Sande, M. and Lowenthal, A. Microelectrophoresis in agar gel of the proteins of the cerebrospinal fluid and central nervous system. J. Neurochem. 4, 135, 1959.

    Article  PubMed  CAS  Google Scholar 

  7. Lowenthal, A. The problem of cerebrospinal studies in multiple sclerosis. In Multiple Sclerosis, a clinical conspectus. Ed. E.J. Field, MTT Press Ltd. p. 207, 1977.

    Google Scholar 

  8. Sigurdsson, B., Karcher, D., van Sande, M. and Lowenthal, A. Electrophoresis of the serum and the CSF proteins in sheep neurological diseases. Protides of the Biological Fluids, 8th Colloquium, Bruges, 1960. Elsevier, Amsterdam, p. 110, 1961.

    Google Scholar 

  9. Janssens, J. Homogene konijnen antilichamen tegen Micrococus Lysodeikticus. V.U.B. Faculteit Wetenschappen. Proefschrift licentiaat in de scheikundige wetenschappen, Sept. 1972.

    Google Scholar 

  10. Strosberg, A.D., Karcher, D. and Lowenthal, A. Structure and idiotype of human homogeneous antibodies. Fed. Proc. (abstr.) 969, 1975.

    Google Scholar 

  11. Prineas, J.W., Raine, C.S., Connell, F.. and Wright, R.G. Bound immunoglobulin G in chronic multiple sclerosis plaques. 11th World Congress of Neurology, Excerpta Medica, Amsterdam, 300, 1977.

    Google Scholar 

  12. Link, H. and Muller, R. Arch. Neurol. 25, 326, 1971.

    Article  PubMed  CAS  Google Scholar 

  13. Vandvik, B. and E. Norrby. Oligoclonal IgG antibody response with central nervous system to different measles virus antigens in SSPE. Proc. Nat. Sci. USA Vol. 70, pp 1060, 1973.

    Article  CAS  Google Scholar 

  14. Vandvik, B. Gel-precipitating measles virus antibodies in SSPE Relation to oligoclonal IgG proteins in the CSF and serum, and the occurrence of two separate fractions of antibody to virus nucleocapsids. Acta Path. Microbiol. Scand. Sect. C. 85: 324, 1977

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1979 Plenum Press, New York

About this chapter

Cite this chapter

Lowenthal, A. (1979). Restricted Heterogeneity of the IgG in Neurology. In: Karcher, D., Lowenthal, A., Strosberg, A.D. (eds) Humoral Immunity in Neurological Diseases. NATO ASI Series, vol 24. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1003-7_37

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-1003-7_37

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1005-1

  • Online ISBN: 978-1-4684-1003-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics