Abstract
The determination of plasma proteins in cerebrospinal fluid (CSF) enables us to assess the filtration process through the blood-brain barrier. Their increase generally indicates the existence of an inflammatory reaction in neurological tissues. Particular attention has been paid to IgG because of its possible local origin and its determination is now fairly common. On a theoretical basis, the determination of IgM in CSF should be more useful than that of IgG. Because IgM is less liable to gain access to CSF by mere transsudation on account of its large molecular size, an increase in IgM concentration should be a better index of the local immune response. Moreover, IgM should become detectable at earlier stages of the immune process as it is generally the first antibody to be produced. However, in practice, the determination of IgM in CSF is not easy as it requires very sensitive methods.
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Aspirant at the “Fonts National de la Recherche Scientifique”, Brussels.
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© 1979 Plenum Press, New York
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Sindic, C., Cambiaso, C., Masson, P.L., Laterre, E.C. (1979). Determination of IgM in the Cerebrospinal Fluid by Particle Counting Immunoassay (PACIA). In: Karcher, D., Lowenthal, A., Strosberg, A.D. (eds) Humoral Immunity in Neurological Diseases. NATO ASI Series, vol 24. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1003-7_31
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DOI: https://doi.org/10.1007/978-1-4684-1003-7_31
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