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The Role of Initiation Factors in the Shut-Off of Protein Synthesis

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Book cover The Molecular Biology of Picornaviruses

Part of the book series: NATO Advanced Study Institutes Series ((NSSA,volume 23))

Abstract

The shut-off of protein simthesis in virus-infected cells is a phenomenon that has attracted the attention of several investigators. In an attempt to provide an explanation at the molecular level for the mechanism of shut-off, studies were initially carried out with virus-infected cells. Since the results of this kind of studies are extensively discussed in the proceeding chapter of this book, we will concentrate on a particular aspect, namely the role of initiation factors on the virus-induced inhibition of host protein synthesis.

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References

  1. BALTIMORE, D. In Biochemistry of Viruses (1969), Levy, H.B. ed. pp. 101–176, Marcel Dekker, New York.

    Google Scholar 

  2. LEIBOWITZ, E. and PENMAN, S. J. Virol. (1971), 8, 661–668.

    PubMed  CAS  Google Scholar 

  3. FERNANDEZ-MUNOZ, E. and DARNELL, J.E. J. Virol. (1976), 126, 719–726.

    Google Scholar 

  4. SABORIO, J.L., PONG, S.S. and KOCH, G. J. Mol. Biol. (1974), 85, 195–211.

    Article  CAS  Google Scholar 

  5. NUSS, D.L., OPPEEMAN, H. and KOCH, G. Proc. Natl. Acad. Sci. U.S.A. (1975), 72, 1258–1262.

    Article  PubMed  CAS  Google Scholar 

  6. LAWRENCE, C. and THACH, E.E. J. Virol. (1974), 14, 598–610.

    PubMed  CAS  Google Scholar 

  7. ABREU, S. and LUCAS-LENARD, J. J. Virol. (1976), 18, 182–194.

    PubMed  CAS  Google Scholar 

  8. GOLINI, P., THACH, S.S., BIRGE, C.H., SAFER, B., MERRICK, W.C. and THAHC, E.E. Proc. Natl. Acad. Sci. U.S.A. (1976), 33, 3040–3044.

    Article  Google Scholar 

  9. BAGLIONI, C., SIMILI, M. and SHAPEITZ, D.A. Nature (London) (1978), 275, 240–243.

    Article  CAS  Google Scholar 

  10. ROSE, J.K., TEACHSEL, H., LEONG, K. and BALTIMORE, D. Proc. Natl. Acad. Sci. U.S.A. (1978), 75, 2752–2756.

    Article  Google Scholar 

  11. WEBER, L.A., FEMAN, E. and BAGLIONI, C. Biochemistry (1975), 14, 5515–5521.

    Article  Google Scholar 

  12. EHRENFELD, E. and HUNT, T. Proc. Natl. Acad. Sci. U.S.A. (1971), 68, 1075–1078.

    Article  PubMed  CAS  Google Scholar 

  13. FARRELL, P.J., BALKOW, K., HUNT, T. and JACKSON, E.J. Cell, (1977), 11, 187–200.

    Article  PubMed  CAS  Google Scholar 

  14. LENZ, J.R. and BAGLIONI, C. J. Biol. Chem. (1978), 255, 4219–4225.

    Google Scholar 

  15. TAENOWKA, M.A. and BAGLIONI, C. J. Cell. Physiol. (1978), submitted for publication.

    Google Scholar 

  16. DAENBEOUGH, C., LEGON, S., HUNT, T. and JACKSON, E.J. J. Mol. Biol. (1975), 76, 379–403.

    Google Scholar 

  17. SHAFEITZ, D.A., WEINSTEIN, J. A., SAFER, B., MERRICK, W.C., WEBER, L.A., HICKEY, E.D. and BAGLIONI, C. Nature (London) (1976), 261, 291–294.

    Article  Google Scholar 

  18. DOYLE, S. and HOLLAND, J. J. Virol. (1972), 9, 22–28.

    PubMed  CAS  Google Scholar 

  19. EHRENFELD, E. and LUND, H. Virology (1977) 80, 297–508.

    Article  PubMed  CAS  Google Scholar 

  20. STAEHELIN, T., TEACHSEL, H., EENI, B., BOSCHETTI, A. and SHREIER, M.H. In Proc. 10th PEBS Meeting (1975), PP. 509–525, Elsevier Scientific Publishing Co., Amsterdam.

    Google Scholar 

  21. FREIESTEIN, C. and BLOBEL, G. Proc. Natl. Acad. Sci. U.S.A. (1975), 72, 3392–3396.

    Article  Google Scholar 

  22. SHAFEITZ, D.A. and ANDEESON, W.P. J. Biol. Chem. (1970), 245, 5553–5559.

    Google Scholar 

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© 1979 Plenum Press, New York

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Baglioni, G., Maroney, P.A., Simili, M. (1979). The Role of Initiation Factors in the Shut-Off of Protein Synthesis. In: Pérez-Bercoff, R. (eds) The Molecular Biology of Picornaviruses. NATO Advanced Study Institutes Series, vol 23. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1000-6_5

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  • DOI: https://doi.org/10.1007/978-1-4684-1000-6_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1002-0

  • Online ISBN: 978-1-4684-1000-6

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