Abstract
The methods at present adopted for the control of the substrate for production of modified live virus vaccines are well established. They involve maintaining colonies of chickens, ducks or rabbits which are the source of primary cells for making such vaccines. These colonies are regularly monitored to exclude infections. The use of human diploid cell lines like WI38 and MRC5 are now internationally accepted as satisfactory substrates for these vaccines and bring the benefits of a defined seed system to the cell substrates as well as to the virus seed. These benefits are consistency and stability; and the ability to use a pretested seed.
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© 1979 Plenum Press, New York
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Beale, A.J. (1979). Choice of Cell Substrate for Biological Products. In: Petricciani, J.C., Hopps, H.E., Chapple, P.J. (eds) Cell Substrates. Advances in Experimental Medicine and Biology, vol 118. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0997-0_9
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DOI: https://doi.org/10.1007/978-1-4684-0997-0_9
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