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Viral Vaccines under Development: A Third Generation

  • Chapter
Cell Substrates

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 118))

Abstract

These are exciting times in virology, immunology and molecular biology, and there is a brisk pace of advance in the basic sciences which provide tools for vaccine development. Additionally, the brilliant success of vaccines created in the fifties and sixties has spawned a host of attempts to apply active immunization principles to the prevention of numerous viral diseases which still evade efforts at control. Partial reviews of current vaccine candidates have appeared in profusion in recent months, and so I have modified my initial purpose for this presentation. Rather than attempting a compendious “state of the art” effort concerning the candidate vaccines themselves, my aim here will be twofold. First, I wish to highlight some of the recent scientific advances which can and/or should be elements in rational vaccine development. Second, I will assess several of the current candidate vaccines in the context of new knowledge with the goal of identifying factors that constitute limits to their further improvement. I should in good conscience confess at the outset that my attention to cell substrates per se will be somewhat peripheral except as I perceive them to be the central factor which limits progress in a given context.

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Authors and Affiliations

  1. Department of Medical Microbiology and Pediatrics, University of Wisconsin Medical School, 497 Medical Sciences Building, Madison, Wisconsin, 53706, USA

    June E. Osborn M.D.

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  1. June E. Osborn M.D.
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  1. Bureau of Biologics of the Food and Drug Administration, Bethesda, Maryland, USA

    John C. Petricciani  & Hope E. Hopps  & 

  2. W. Alton Jones Cell Science Center, Lake Placid, New York, USA

    Paul J. Chapple

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Osborn, J.E. (1979). Viral Vaccines under Development: A Third Generation. In: Petricciani, J.C., Hopps, H.E., Chapple, P.J. (eds) Cell Substrates. Advances in Experimental Medicine and Biology, vol 118. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0997-0_8

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