Viral Vaccines under Development: A Third Generation

  • June E. Osborn
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 118)


These are exciting times in virology, immunology and molecular biology, and there is a brisk pace of advance in the basic sciences which provide tools for vaccine development. Additionally, the brilliant success of vaccines created in the fifties and sixties has spawned a host of attempts to apply active immunization principles to the prevention of numerous viral diseases which still evade efforts at control. Partial reviews of current vaccine candidates have appeared in profusion in recent months, and so I have modified my initial purpose for this presentation. Rather than attempting a compendious “state of the art” effort concerning the candidate vaccines themselves, my aim here will be twofold. First, I wish to highlight some of the recent scientific advances which can and/or should be elements in rational vaccine development. Second, I will assess several of the current candidate vaccines in the context of new knowledge with the goal of identifying factors that constitute limits to their further improvement. I should in good conscience confess at the outset that my attention to cell substrates per se will be somewhat peripheral except as I perceive them to be the central factor which limits progress in a given context.


Herpes Simplex Respiratory Syncytial Virus Herpes Simplex Type Vaccine Development Human Cytomegalovirus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Plenum Press, New York 1979

Authors and Affiliations

  • June E. Osborn
    • 1
  1. 1.Department of Medical Microbiology and PediatricsUniversity of Wisconsin Medical SchoolMadisonUSA

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