Quantitation in the Evaluation of Cell Substrates for Viral Vaccine Production

  • Wade P. Parks
  • Elizabeth S. Hubbell
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 118)


Although the subject of cell substrates for viral production has recently been reviewed (1) certain points of considerable interest and relevance were not discussed. Issues of benefits and risks have been discussed in the present symposium in the preceding paper (2). In the present paper, we would like to stress the need for quantitative data related to genetic and presumably nongenetic alterations in various cell substrates. These changes may occur in the cells themselves or in their products. First, in order to discuss the issues of cell substrate selection certain definitions are necessary.


Mouse Mammary Tumor Virus Cell Substrate Mammary Tumor Cell Line Rubella Virus Vaccine Mouse Mammary Tumor Cell Line 
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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • Wade P. Parks
    • 1
  • Elizabeth S. Hubbell
    • 1
  1. 1.Department of MicrobiologyUniversity of Miami School of Medicine and Veterans Administration HospitalMiamiUSA

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