Quantitation in the Evaluation of Cell Substrates for Viral Vaccine Production
Although the subject of cell substrates for viral production has recently been reviewed (1) certain points of considerable interest and relevance were not discussed. Issues of benefits and risks have been discussed in the present symposium in the preceding paper (2). In the present paper, we would like to stress the need for quantitative data related to genetic and presumably nongenetic alterations in various cell substrates. These changes may occur in the cells themselves or in their products. First, in order to discuss the issues of cell substrate selection certain definitions are necessary.
KeywordsMouse Mammary Tumor Virus Cell Substrate Mammary Tumor Cell Line Rubella Virus Vaccine Mouse Mammary Tumor Cell Line
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