Report of Ad Hoc Committee on Karyological Controls of Human Cell Substrates
A conference on the Standardization of Cell Substrates for the Production of Virus Vaccines was jointly sponsored by the World Health Organization and by the International Association of Biological Standardization at Geneva in 1976. Participants at the meeting agreed that recommendations then current regarding karyological control of human cell substrates should be reviewed and revised. Extensive experience using human diploid cells in vaccine manufacture as documented at that symposium indicated that certain karyological requirements of existing standards should be eliminated or modified. An Ad Hoc Committee appointed by the Chairman of the conference, Dr. Frank Perkins, was charged with this task; however, since opinions varied widely regarding modification this committee requested the organization of a karyology workshop.
KeywordsSecondary Constriction Metaphase Cell Control Authority Cell Substrate Population Doubling Level
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